A5008551271- Neural dynamics and brain function
- Optical Imaging and Spectroscopy Techniques
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Non-Invasive Vital Sign Monitoring
- EEG and Brain-Computer Interfaces
- Memory and Neural Mechanisms
- Sleep and Wakefulness Research
- Olfactory and Sensory Function Studies
- Circadian rhythm and melatonin
- Dementia and Cognitive Impairment Research
- Functional Brain Connectivity Studies
- Neuroendocrine regulation and behavior
- Neural Networks and Applications
- Photoacoustic and Ultrasonic Imaging
- Heart Rate Variability and Autonomic Control
- Infrared Thermography in Medicine
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Spectroscopy Techniques in Biomedical and Chemical Research
- Tensor decomposition and applications
- Parallel Computing and Optimization Techniques
- Visual perception and processing mechanisms
Korea Institute of Science and Technology
2016-2025
Korea Institute of Brain Science
2011-2025
Korean Association Of Science and Technology Studies
2014-2025
Korea University of Science and Technology
2013-2023
Seoul National University
2023
Bio-Medical Science (South Korea)
2019-2023
Korea University
2023
University of Science and Technology
2011-2019
Convergence Research Center for Diagnosis Treatment and Care System of Dementia
2018
University of Ulsan
2016
Significance When we are awake, purposeful thinking and behavior require the synchronization of brain cells involved in different aspects same task. Cerebral cortex electrical oscillations gamma (30–80 Hz) range particularly important such synchronization. In this report identify a particular subcortical cell type which has increased activity during waking is activating cerebral generating oscillations, enabling active cortical processing. Abnormalities mechanisms controlling disordered...
The aim of this study was to compare functional cerebral hemodynamic signals obtained simultaneously by near infrared spectroscopy (NIRS) and magnetic resonance imaging (fMRI). contribution superficial layers (skin skull) the NIRS signal also assessed. Both methods were used generate maps motor cortex area during a periodic sequence stimulation finger motion rest. In all subjects we found good collocation brain activity centers revealed both methods. We high temporal correlation between BOLD...
The <i>Journal of Biomedical Optics</i> (JBO) is a Gold Open Access journal that publishes peer-reviewed papers on the use novel optical systems and techniques for improved health care biomedical research.
A1 Functional advantages of cell-type heterogeneity in neural circuits Tatyana O. Sharpee A2 Mesoscopic modeling propagating waves visual cortex Alain Destexhe A3 Dynamics and biomarkers mental disorders Mitsuo Kawato F1 Precise recruitment spiking output at theta frequencies requires dendritic h-channels multi-compartment models oriens-lacunosum/moleculare hippocampal interneurons Vladislav Sekulić, Frances K. Skinner F2 Kernel methods reconstruction current sources from extracellular...
Visual scoring of murine EEG signals is time-consuming and subject to low inter-observer reproducibility. The Racine scale for behavioral seizure severity does not provide information about interictal or sub-clinical epileptiform activity. An automated algorithm analysis was developed using total signal variation wavelet decomposition identify spike, seizure, other abnormal types in single-channel collected from kainic acid-treated mice. validated on multi-channel γ-butyrolacetone-treated...
Electroencephalography (EEG) is a standard tool for monitoring brain states in humans. Understanding the molecular and cellular mechanisms underlying diverse EEG rhythms can be facilitated by using mouse models under molecular, pharmacological, or electrophysiological manipulations. The small size of brain, however, poses severe limitation spatial information EEG. To overcome this limitation, we devised polyimide based microelectrode array (PBM array) with nanofabrication technologies....
Sleep spindles in humans have been classified as slow anterior and fast posterior spindles; recent findings indicate that their profiles differ according to pharmacology, pathology, function. However, little is known about the generation mechanisms within thalamocortical system for different types of spindles. In this study, we aim investigate electrophysiological behaviors topographically distinctive by applying high-density EEG simultaneous thalamic LFP recordings mice.32-channel...
Abstract Chronic pain is highly prevalent and linked to a broad range of comorbidities, including sleep disorders. Epidemiological clinical evidence suggests that chronic disruption (CSD) leads heightened sensitivity, referred as CSD-induced hyperalgesia. However, the underlying mechanisms are unclear. The thalamic reticular nucleus (TRN) has unique integrative functions in sensory processing, attention/arousal spindle generation. We report TRN played an important role hyperalgesia mice,...
Abstract Brain activity is associated with physiological changes, which alter the optical properties of tissue in near‐infrared part spectrum. Two major types signals following functional brain activation can be distinguished: a slow signal due to hemodynamic changes and fast signal, directly related neuronal activity. The small therefore difficult detect. We used specially noise‐optimized frequency‐domain spectrometer π‐sensor, was expected particularly sensitive deeper layers, investigate...
We investigated how neural dynamics support role differentiation in group foraging by mice cohabiting with a predatory spider robot serving as mobile food platform. While solitary behaviors were consistent among mice, revealed distinct roles (working, participating, and freeriding) that solidified over time, leading to an imbalance (Gini = 0.5) across five groups. Recordings from the medial prefrontal cortex (mPFC), nucleus accumbens (NAc), basolateral amygdala (BLA) enhanced beta power...
The aim of our study was to explore the possibility detecting hemodynamic changes in brain using phase intensity modulated optical signal. To obtain signals with highest possible signal-to-noise ratio, we performed a series simultaneous NIRS-fMRI measurements, subsequent correlation time courses both measurements. cognitive paradigm used arithmetic calculations, acquired sensors placed on forehead. Measurements were done seven healthy subjects. In five subjects demonstrated between obtained...
Objectives: In patients with schizophrenia, γ-band (30–70 Hz) auditory steady-state electroencephalogram responses (ASSR) are reduced in power and phase locking. Here, we examined whether γ-ASSR deficits also present a mouse model of whose behavioural changes have shown schizophrenia-like endophenotypes. Methods: Electroencephalogram frontal cortex local field potential primary were recorded phospholipase C β1 (PLC-β1) null mice during binaural click trains at different rates (20–50 Hz),...
Abstract Compensatory elevation in NREM sleep EEG delta power has been typically observed following prolonged wakefulness and widely used as a homeostasis indicator. However, recent evidence human rodent chronic restriction (CSR) studies suggests that is not progressively increased despite of accumulated loss over days. In addition, there little progress understanding how different brain regions responds to CSR. Using novel high-density electrode arrays the mouse model CSR where mice...
Localized surface plasmon resonance (LSPR) is the phenomenon that observed on specific metal nanoparticles (NPs) like Au, Ag which can be used for sensitive detection many kinds of biomaterials. Dopamine (DA) a typical neurotransmitter considered as indicator some neural diseases. Due to its small size, it very difficult detect DA at low concentrations directly and sensitively with conventional sensing techniques. In this research, we propose sensor based LSPR phenomenon. Electrochemical...
Abstract Identifying how spatially distributed information becomes integrated in the brain is essential to understanding higher cognitive functions. Previous computational and empirical studies suggest a significant influence of network structure on function. However, there have been few analytical approaches explain role shaping regional activities directionality patterns. In this study, methods are applied coupled oscillator model implemented inhomogeneous networks. We first derive...
Homeostatic rebound in rapid eye movement (REM) sleep normally occurs after acute deprivation, but REM settles on a persistently elevated level despite continued accumulation of debt during chronic restriction (CSR). Using high-density EEG mice, we studied how this pattern global regulation is implemented cortical regions with different functions and network architectures. We found that across all areas, slow oscillations repeated the behavioral persistent enhancement CSR, whereas...