A5028438246- Visual perception and processing mechanisms
- Retinal Development and Disorders
- Photoreceptor and optogenetics research
- Ion channel regulation and function
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Zebrafish Biomedical Research Applications
- Neurobiology and Insect Physiology Research
- Optical Polarization and Ellipsometry
- Glaucoma and retinal disorders
- Neural dynamics and brain function
- Spaceflight effects on biology
- Hearing Loss and Rehabilitation
- Biochemical effects in animals
- Morphological variations and asymmetry
- Hemispheric Asymmetry in Neuroscience
- Hearing, Cochlea, Tinnitus, Genetics
The University of Texas at Austin
2015-2020
University of Pittsburgh
2013
Tinnitus, the perception of phantom sound, is often a debilitating condition that affects many millions people. Little known, however, about molecules participate in induction tinnitus. In brain slices containing dorsal cochlear nucleus, we reveal tinnitus-specific increase spontaneous firing rate principal neurons (hyperactivity). This hyperactivity observed only noise-exposed mice develop tinnitus and nucleus regions are sensitive to high frequency sounds. We show reduction Kv7.2/3 channel...
Stereopsis is a ubiquitous feature of primate mammalian vision, but little known about if and how rodents such as mice use stereoscopic vision. We used random dot stereograms to test for stereopsis in male female mice, they were able discriminate near from far surfaces over range disparities, with diminishing performance small large binocular disparities. Based on two-photon measurements disparity tuning, the disparities represented visual cortex aligns behavior covers broad When we examined...
Abstract A central transformation that occurs within mammalian visual cortex is the change from linear, polarity-sensitive responses to nonlinear, polarity-insensitive responses. These neurons are classically labelled as either simple or complex, respectively, on basis of their response linearity (Skottun et al., 1991). While difference between cell classes clear when stimulus strength high, reducing diminishes differences types and causes some complex cells respond (Crowder 2007; van Kleef...
We stabilize the dynamic visual world on our retina by moving eyes in response to motion signals. Coordinated movements between two are characterized as version when both move same direction and vergence opposite directions. Vergence eye necessary track objects three dimensions. In primates they can be elicited intraocular differences either spatial signals (disparity) or velocity, requiring integration of left right inputs. Whether mice capable similar behaviors is not known. To address...
In order for animals with binocular vision to use retinal image disparity infer depth, they must be able maintain some alignment between the eyes. Primates and carnivores frequently make coordinated saccades, when fixate on an object, their eyes converge or diverge align images at that point. Rodents do not have a fovea, saccade less frequently, are typically directed different objects. However, there is tuning in primary visual cortex of mice. To study how mice might this discriminate we...
Despite the presence of disparity selective neurons in mouse primary visual cortex, there has been no evidence that mice integrate binocular cues to drive behavior. Previous work demonstrated rodents can estimate size a gap (Legg & Lambert, 1990; Kerr et al., 2013), but it is unclear from these studies whether are used monocular or binocular. To determine integration behavior, we trained animals distinguish between toward and away motion, presented dichoptically, for which were only...
Disruption in the visual field before critical period can change how neurons primary cortex integrate binocular inputs. Strabismus (ocular misalignment) during development leads to cortical that are almost exclusively monocular when measured by spike rate.The traditional interpretation for this phenomenon is an underlying reduction, or even elimination, of synaptic input neuron from non-preferred eye via activity-dependent competition. Since has relied on recording suprathreshold activity...