A5100415922- Hearing, Cochlea, Tinnitus, Genetics
- Ion Channels and Receptors
- Cardiovascular Function and Risk Factors
- Hearing Loss and Rehabilitation
- Streptococcal Infections and Treatments
- Signaling Pathways in Disease
- Ion channel regulation and function
- Neural dynamics and brain function
- Antioxidant Activity and Oxidative Stress
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cell death mechanisms and regulation
- Mitochondrial Function and Pathology
- Retinoids in leukemia and cellular processes
- Organ Transplantation Techniques and Outcomes
- Neuroscience and Neuropharmacology Research
- Cardiac electrophysiology and arrhythmias
- Inflammasome and immune disorders
- Cancer Treatment and Pharmacology
- Polysaccharides and Plant Cell Walls
- Pain Mechanisms and Treatments
- Microbial infections and disease research
- Cardiac Fibrosis and Remodeling
- Mesenchymal stem cell research
- Metabolism, Diabetes, and Cancer
- Infectious Diseases and Tuberculosis
Chengdu Third People's Hospital
2025
Southwest Jiaotong University
2025
University of Science and Technology of China
2024
Shandong University
2024
Wuhan University
2023
First Affiliated Hospital of Zhengzhou University
2023
Zhongnan Hospital of Wuhan University
2023
Chengdu Military General Hospital
2018-2020
National Clinical Research
2018
Chinese PLA General Hospital
2018
Tinnitus, the perception of phantom sound, is often a debilitating condition that affects many millions people. Little known, however, about molecules participate in induction tinnitus. In brain slices containing dorsal cochlear nucleus, we reveal tinnitus-specific increase spontaneous firing rate principal neurons (hyperactivity). This hyperactivity observed only noise-exposed mice develop tinnitus and nucleus regions are sensitive to high frequency sounds. We show reduction Kv7.2/3 channel...
Vulnerability to noise-induced tinnitus is associated with increased spontaneous firing rate in dorsal cochlear nucleus principal neurons, fusiform cells. This hyperactivity caused, at least part, by decreased Kv7.2/3 (KCNQ2/3) potassium currents. However, the biophysical mechanisms underlying resilience tinnitus, which observed noise-exposed mice that do not develop (non-tinnitus mice), remain unknown. Our results show noise exposure induces, on average, a reduction KCNQ2/3 channel activity...
Sepsis, a systemic inflammatory response to infection, is the leading cause of death in intensive care unit (ICU). Previous studies indicated that mesenchymal stromal cells (MSCs) might have therapeutic potential against sepsis. The current study was designed investigate effects MSCs on sepsis and underlying mechanisms focusing inflammasome activation macrophages. results demonstrated bone marrow-derived stem (BMSCs) significantly increased survival rate organ function cecal ligation...
Homeostatic mechanisms maintain homogeneous neuronal behavior among neurons that exhibit substantial variability in the expression levels of their ionic conductances. In contrast, mechanisms, which generate heterogeneous across a population, remain poorly understood. We addressed this problem dorsal cochlear nucleus, where principal exist two qualitatively distinct states: spontaneously active or not active. Our studies reveal activity states are generated by differential Ba 2+ -sensitive,...
Cardiac fibroblasts (CFs) are a critical cell population responsible for myocardial extracellular matrix homeostasis. After stimulation by infarction (MI), CFs transdifferentiate into cardiac myofibroblasts (CMFs) and play fundamental role in the fibrotic healing response. Transient receptor potential ankyrin 1 (TRPA1) channels cationic ion with high fractional Ca2+ current, they known to influence function after MI injury; however, molecular mechanisms regulating CMF transdifferentiation...
P53 is known as a transcription factor to control apoptotic cell death through regulating series of target genes in nucleus. There accumulating evidences show that p53 can directly induce apoptosis independent way at mitochondria. However, the mechanism by which translocation into mitochondria response oxidative stress remains unclear. Here, glucose oxidase (GOX) was used ROS generation HepG2 cells and liver tissues mice. The results showed stabilized translocated time dose dependent manner...
Vascular smooth muscle cell (VSMC) proliferation is a crucial cause of vascular neointima hyperplasia and restenosis, thus limiting the long-term efficacy percutaneous intervention. We explored role wild-type p53-induced phosphatase 1 (Wip1), potent regulator tumorigenesis atherosclerosis, in VSMC hyperplasia.Animal model restenosis was established wild type C57BL/6J VSMC-specific Tuberous Sclerosis (TSC1)-knockdown mice by wire injury. observed increased protein levels Wip1, phospho (p)-S6...
In a neuronal population, several combinations of its ionic conductances are used to attain specific firing phenotype. Some neurons present heterogeneity in their firing, generally produced by expression conductance, but how additional vary along order homeostatically regulate membrane excitability is less known. Dorsal cochlear nucleus principal neurons, fusiform display heterogeneous spontaneous action potential activity and thus represent an appropriate model study the role different...
Coronary heart disease patients with type 2 diabetes were subject to higher vulnerability for cardiac ischemia-reperfusion (I/R) injury. This study was designed evaluate the impact of ZP2495 (a glucagon-GLP-1 dual-agonist) on function and energy metabolism after myocardial I/R injury in db/db mice a focus mitochondrial function. C57BLKS/J-lepr+/lepr+ (BKS) received 4-week treatment glucagon, ZP131 (GLP-1 receptor agonist), or ZP2495, followed by The results showed that function, glucose...
Neurofibromin 2 (NF2), a potent tumor suppressor, is reported to inhibit proliferation in several cell types.The role of NF2 neointima hyperplasia after vascular injury unknown.We explored the proliferation, migration smooth muscle (VSMC) and injury.NF2 phosphorylation was elevated VSMC subjected platelet-derived growth factor (PDGF)-BB artery injury.Mice deficient for Nf2 showed enhanced injury, increased PDGF-BB treatment.Mechanistically, we observed nuclear p-NF2, declined...
Gastrointestinal paresthesia and dysmotility are common side effects of vincristine (VCR) chemotherapy, which have become one the factors for dose reduction, therapy delay or discontinuation. However, mechanism is not entirely clear, whether it related to autonomic nerves injury remains unknown. Therefore, we aimed study VCR-induced gastrointestinal toxicity changes in mesenteric afferent activity. The a single VCR stimulation long-term systemic treatment on activity were investigated by...
Neointimal hyperplasia could be one of the most important complications after balloon angioplasty. Since calcium signaling has several physiologic effects on regulation proliferation and migration vascular smooth muscle cells (VSMCs), it was hypothesized that transmembrane protein 66 (TMEM66), a store operated entry (SOCE)‑associated regulatory factor, possesses protection against injury. The rat balloon‑induced carotid artery injury model performed. Histological analysis used to check...
Abstract Diabetes mellitus causes endothelial dysfunction, which further exacerbates peripheral arterial disease (PAD). Improving function via reducing oxidative stress (OS) may be a promising therapy for diabetic PAD. Activation of liver X receptor (LXR) inhibits excessive OS and provides protective effects on cells in individuals. Therefore, we investigated the LXR agonist treatment PAD with focus modulating OS. We used streptozotocin‐induced diabetes mouse model combined hindlimb...
The co-occurrence of Lemierre's syndrome, primarily triggered by Fusobacterium necrophorum following oropharyngeal infection, with diabetic ketoacidosis (DKA) in diabetes mellitus (DM) patients, underscores a rare but life-threatening clinical scenario. syndrome induced DKA is extremely rare, only one case report adult and no yet reported elderly.
The transient receptor potential cation channel subfamily M member 8 (TRPM8) is a kind of non-selective which controls Ca2+ homeostasis. Mutations in TRPM8 were related to dry eye diseases (DED). Here we constructed knockout cell line WAe009-A-A from the original embryonic stem H9 using CRISPR/Cas9 technology, maybe helpful for exploring pathogenesis DED. cells possess morphology and pluripotency as well normal karyotype, have ability differentiating into three germ layers vitro.
Background: Hypertensive ventricular remodeling is a common cause of heart failure. Activation and accumulation cardiac fibroblasts the key contributors to this progression. Our previous studies indicate that transient receptor potential ankyrin 1 (TRPA1), Ca 2+ channel necessary sufficient, play prominent role in remodeling. However, molecular mechanisms regulating remain poorly understood. Methods: We used TRPA1 agonists cinnamaldehyde (CA) pretreatment knockout mice understand...