A5000477855- Liver Disease Diagnosis and Treatment
- Immune cells in cancer
- Adipose Tissue and Metabolism
- Genomics, phytochemicals, and oxidative stress
- S100 Proteins and Annexins
- Adipokines, Inflammation, and Metabolic Diseases
- Alcohol Consumption and Health Effects
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Drug-Induced Hepatotoxicity and Protection
- Inflammasome and immune disorders
- Heme Oxygenase-1 and Carbon Monoxide
- Natural product bioactivities and synthesis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Organ Transplantation Techniques and Outcomes
- Peroxisome Proliferator-Activated Receptors
- Eicosanoids and Hypertension Pharmacology
- Neuroinflammation and Neurodegeneration Mechanisms
- Pancreatic function and diabetes
- Mitochondrial Function and Pathology
- Acute Kidney Injury Research
- Diet, Metabolism, and Disease
- Calcium signaling and nucleotide metabolism
- Electromagnetic Fields and Biological Effects
- Ginger and Zingiberaceae research
- Risk and Safety Analysis
Air Force Medical University
2016-2025
Ministry of Education of the People's Republic of China
2024
Incidence of hepatocellular carcinoma (HCC) is dramatically increasing and the third cause cancer death worldwide. One key approach to control HCC chemoprevention by naturally occurring agents. This study aims at investigating antitumor effect oleanolic acid (OA) molecular mechanisms. BALB/c mice were injected subcutaneously with HepG2 cells establish transplanted tumors. Apoptosis cell cycle arrest-related markers signaling cascades determined western blot, immunofluorescence, reverse...
Macrophage recruitment and pro-inflammatory differentiation are hallmarks of various diseases, including infection sepsis. Although studies suggest that mitochondria may regulate macrophage immune responses, it remains unclear whether mitochondrial mass affects differentiation. Here, we found lipopolysaccharide (LPS)-activated macrophages possess higher than resting cells. Therefore, this study aimed to explore the functional role molecular mechanisms increased in differentiated macrophages....
Diabetes mellitus (DM) is a metabolic disorder characterized by chronic hyperglycemia. Although the clear mechanisms of DM and insulin resistance are still to be cleared, it has been well documented that reactive oxygen species (ROS) play pivotal role in multiple types resistance. For past few years, natural substances have shown potential treatment DM. Attention especially focused on plants rich triterpenoids, which generally show antioxidant antiglycation effect. In our previous studies,...
Polychlorinated biphenyls (PCB) is a major type of persistent organic pollutants (POPs) that act as endocrine-disrupting chemicals. In the current study, we examined mechanism underlying effect PCB-153 on glucose and lipid metabolism in vivo vitro. We found induced per se worsened high fat diet (HFD)-resulted increase blood level insulin intolerance. addition, HFD-resulted triglyceride content adipose mass. Moreover, concentration-dependently inhibited insulin-dependent uptake accumulation...
Abstract Bisphenol A (BPA) is an endocrine-disrupting chemical (EDC) associated with non-alcoholic fatty liver disease (NAFLD). The effects of gestational BPA exposure on hepatic lipid accumulation in offspring are not fully understood. Here, we investigate the sex-dependent and glucose metabolism mice to reveal mechanisms underlying exposure-associated NAFLD. Pregnant were administered gavage or without 1 μg kg −1 day at embryonic 7.5 (E7.5)–E16.5. Hepatic evaluated these models. Both male...
2,3,5,4′‐Tetrahydroxystilbene‐2‐O‐ β ‐D‐glucoside (TSG), an important monomer extracted from Polygonum multiflorum, can prevent a number of inflammation associated chronic diseases. However, the mechanism involved in TSG inducing anti‐inflammatory role remains unclear. As inducible antioxidant enzyme, Heme oxygenase‐1 (HO‐1), is crucial for protecting mammalian cells against adverse stimuli. Here, we found that treatment strongly induces expression HO‐1 NRF2‐depended manner. Meanwhile,...
Aims: The liver undergoes marked changes in the rate of proliferation during normal development and regeneration through coordinated activity numerous signaling pathways. Little is known, however, about events that act upstream these Here, we explore modulatory effects hydrogen peroxide (H2O2) on pathways context regeneration. Results: We show H2O2 production after partial hepatectomy tightly regulated time by specific H2O2-producing scavenging proteins dose dependently triggers two distinct...
Paraquat (PQ) is a widely used agro-chemical in agriculture and highly toxic to humans. Although the mechanism of PQ poisoning not clear, it has been well documented that reactive oxygen species (ROS) generation apoptosis play pivotal roles. Alternatively, chlorogenic acid (CA) biologically active dietary polyphenol, playing several therapeutic However, known whether CA protective effect on PQ-induced apoptosis. Here, we investigated preventing explored underlying mechanisms. A549 cells were...
Alcoholic liver disease (ALD) has become an important hazard to public and personal health. Oxidative stress is believed be responsible for the pathological changes in ALD. Previous studies have showed that insulin, a classic regulator of glucose metabolism, significant anti-oxidative function plays role maintaining redox balance. For addressing effects mechanisms insulin pre-administration on ethanol-induced oxidative injury, we investigated histopathology, inflammatory factors, apoptosis,...
P53 is known as a transcription factor to control apoptotic cell death through regulating series of target genes in nucleus. There accumulating evidences show that p53 can directly induce apoptosis independent way at mitochondria. However, the mechanism by which translocation into mitochondria response oxidative stress remains unclear. Here, glucose oxidase (GOX) was used ROS generation HepG2 cells and liver tissues mice. The results showed stabilized translocated time dose dependent manner...
Epithelial-to-mesenchymal transition (EMT) is critical to the progression of several disease processes including carcinoma metastasis and organ fibrosis. Recent studies show that reactive oxygen species (ROS) mitochondrial dysfunction have been associated with EMT. However, role mitochondria in EMT process remains be elucidated. Through induction using TGF-β1, we demonstrated functions were abnormal by increasing ROS production reducing membrane potential, ATP content complex protein...