A5102003985- Tryptophan and brain disorders
- Animal Nutrition and Physiology
- Glaucoma and retinal disorders
- Stress Responses and Cortisol
- Pharmaceutical and Antibiotic Environmental Impacts
- Cardiovascular Function and Risk Factors
- Liver Disease Diagnosis and Treatment
- Marine and coastal plant biology
- Antifungal resistance and susceptibility
- Mosquito-borne diseases and control
- Antibiotics Pharmacokinetics and Efficacy
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Silkworms and Sericulture Research
- Immune Cell Function and Interaction
- Advanced Biosensing Techniques and Applications
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Viral Infections and Vectors
- S100 Proteins and Annexins
- Extracellular vesicles in disease
- Long-Term Effects of COVID-19
- Viral Infections and Outbreaks Research
Zhongkai University of Agriculture and Engineering
2022-2025
Southern Medical University
2017-2024
Nanfang Hospital
2019-2024
Chinese University of Hong Kong
2024
Shantou University
2024
Tsinghua University
2023-2024
Nantong University
2023-2024
University of Electronic Science and Technology of China
2023-2024
Chengdu Women's and Children's Central Hospital
2024
Chinese Academy of Fishery Sciences
2021-2023
Newly emerging viruses, such as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle Eastern CoVs (MERS-CoV), and H7N9, cause fatal lung injury (ALI) by driving hypercytokinemia aggressive inflammation through mechanisms that remain elusive. In SARS-CoV/macaque models, we determined anti–spike IgG (S-IgG), in productively infected lungs, causes ALI skewing inflammation-resolving response. Alveolar macrophages underwent functional polarization acutely macaques, demonstrating...
Diurnal fluctuations of motor and nonmotor symptoms a high prevalence sleep-wake disturbances in Parkinson disease (PD) suggest role the circadian system modulation these symptoms. However, surprisingly little is known regarding function PD whether dysfunction involved development PD.To determine relationship between timing amplitude 24-hour melatonin rhythm, marker endogenous rhythmicity, with self-reported sleep quality, severity daytime sleepiness, metrics.A cross-sectional study from...
To investigate the effects of fermented Chinese herbal medicine on growth performance, diarrhea rate, nutrient digestibility, and intestinal health weaned piglets, to provide theoretical basis for applying medicines piglet production, a total 162 castrated piglets at 25 days age (Duroc × Landrace Yorkshire, half male female) with an initial body weight 7.77 ± 0.03 kg were randomly divided into following three groups according principle similar weight: basal diet (CON) group, + 3 kg/t (LFHM)...
Background— Central obesity, defined by increased waist circumference or waist:hip ratio (WHR), is associated with cardiovascular events, including heart failure. However, the pathophysiological link between central obesity and adverse outcomes remains poorly understood. We hypothesized that larger WHR are independently worse cardiac mechanics (reduced left ventricular strain systolic [s′] early diastolic [e′] tissue velocities). Methods Results— performed speckle-tracking analysis of...
Surfactin has antiviral activity against various enveloped viruses by inhibiting viral membrane fusion. However, the potential utility of surfactin as an drug is limited its cytotoxicity. In this study, 10 analogues were obtained chemical synthesis and evaluated to determine their anti-PEDV activities, hemolytic critical micelle concentrations. The main goal our study was develop a safer drug; analogue with high low activity. Compared surfactin, one we developed, SLP5, lower activity, same...
Alzheimer's disease (AD) is a prevalent neurodegenerative (ND). In recent years, multiple clinical and animal studies have shown that mitochondrial dysfunction may be involved in the pathogenesis of AD. addition, short-chain fatty acids (SCFA) produced by intestinal microbiota metabolism been considered to important factors affecting central nervous system (CNS) homeostasis. Among main mediators host-microbe interactions, volatile play crucial role. Nevertheless, influence pathways...
Large-scale pigeon farming in China is gradually increasing. However, studies on the basic nutritional requirements of breeding pigeons during lactation, which greatly influence productivity and economic benefits breeding, remain scanty. The objective this study was to determine optimal dietary energy/protein ratio for lactating summer. A total 576 pairs Mimas were randomly divided into 12 groups (n = 48 per treatment), each pair bred 4 squabs. two-way ANOVA design with different protein...
The strong invasiveness and rapid expansion of dengue virus (DENV) pose a great challenge to global public health. However, epidemic patterns mechanisms at genetic scale, particularly in term cross-border transmissions, remain poorly understood. Importation is considered as the primary driver outbreaks China, since 1990 frequent occurrence large has been triggered by imported cases subsequently spread western northern parts China. Therefore, this study aims systematically reveal invasion...
In cohort studies, Type 2 diabetes mellitus has been associated with decreased forced 1 s expiratory volume and vital capacity. We examined if capacity, diffusion lung capacity correlate across different races in a clinical setting.We the medical records of 19,882 adults 18-97 years age our centre from January 2000 to May 2009. After excluding patients diseases causing abnormal function, 4164 subjects were available for analysis. used multiple linear regressions examine cross-sectional...
Kelp (Saccharina japonica) has been intensively cultured in China for almost a century. Its genetic improvement is comparable with that of rice. However, the development its molecular tools extremely limited, thus genes, genetics and genomics. performs an alternative life cycle during which sporophyte generation alternates gametophyte generation. The gametophytes kelp can be cloned crossed. Due to these characteristics, may serve as reference biological studies Volvox, mosses ferns. We...
Exosomes are considered as promising biomarkers for early cancer diagnosis and prognosis. However, the majority of research studies focused on a single type exosomal biomarkers, which cannot comprehensively reflect state accurate diagnosis. To address this problem, we presented ship-shaped microfluidic device containing microcolumn array simultaneous in situ detection surface proteins miRNAs. were first captured microchannels modified with CD63 protein aptamer. Exosomal miRNAs simultaneously...
Porcine reproductive and respiratory syndrome virus (PRRSV) causes disease in pigs of all ages failure sows, resulting great economic losses to the swine industry. In this work, we identified interaction between PSMB4 PRRSV Nsp1α by yeast two-hybrid screening. The PSMB4-Nsp1α was further confirmed coimmunoprecipitation, glutathione
The nutritional requirements of breeding pigeons depend on their physiological period, pattern, and environmental conditions. Despite works reduced litter size in winter production to combat high mortality the poor welfare squabs, there are few studies related these pigeons. A total 432 pairs European Mimas were randomly divided into 9 groups which 3 crude protein (CP) levels (15, 16.5, 18%) metabolizable energy (ME) (12.2 MJ/kg, 12.4 12.6 MJ/kg) tested determine optimal "2 + 3" pattern....
Background Comorbidities are common in heart failure ( HF ), and the number of comorbidities has been associated with poor outcomes patients. However, little is known about effect multiple on cardiac mechanics, which could impact pathogenesis . We sought to determine relationship between comorbidity burden adverse mechanics. Methods Results performed speckle‐tracking analysis echocardiograms from HyperGEN study (n=2150). Global longitudinal, circumferential, radial strain, early diastolic...
Objective: Acute respiratory distress syndrome trials powered for mortality require significant resources, limiting the number of evaluable therapies. Validation intermediate endpoints would enhance feasibility testing novel acute therapies in pilot studies and potentially reduce frequency failed large clinical trials. We sought to determine whether a change oxygenation index over first 7 days could discriminate between likely or unlikely show benefit larger Design: A derivation cohort from...
Diastolic wall strain (DWS), defined using posterior thickness (PWT) measurements from standard echocardiographic images (DWS = [PWT(systole)-PWT(diastole)]/PWT(systole)), has been proposed as a marker of left ventricular (LV) diastolic stiffness. However, the equation for DWS is closely related to systolic radial strain, and whether associated with abnormal cardiac mechanics (reduced strains tissue velocities) unknown. We sought determine relationship between mechanics.We calculated...