A5100434508- Immune cells in cancer
- S100 Proteins and Annexins
- Genomics, phytochemicals, and oxidative stress
- Natural product bioactivities and synthesis
- Adipose Tissue and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Inflammasome and immune disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Eicosanoids and Hypertension Pharmacology
- Acute Kidney Injury Research
- Heme Oxygenase-1 and Carbon Monoxide
- Gout, Hyperuricemia, Uric Acid
- Protein Tyrosine Phosphatases
- Immune Response and Inflammation
- Sulfur Compounds in Biology
- Oil Spill Detection and Mitigation
- Cynara cardunculus studies
- SARS-CoV-2 and COVID-19 Research
- FOXO transcription factor regulation
- Whipple's Disease and Interleukins
- IL-33, ST2, and ILC Pathways
Zhejiang Cancer Hospital
2025
Chinese Academy of Sciences
2025
Jiangsu Vocational College of Medicine
2021-2025
Second Hospital of Hebei Medical University
2021-2024
Hebei Medical University
2021-2024
Air Force Medical University
2010-2023
Xi'an Medical University
2023
Humboldt-Universität zu Berlin
2022
Charité - Universitätsmedizin Berlin
2022
Freie Universität Berlin
2022
Incidence of hepatocellular carcinoma (HCC) is dramatically increasing and the third cause cancer death worldwide. One key approach to control HCC chemoprevention by naturally occurring agents. This study aims at investigating antitumor effect oleanolic acid (OA) molecular mechanisms. BALB/c mice were injected subcutaneously with HepG2 cells establish transplanted tumors. Apoptosis cell cycle arrest-related markers signaling cascades determined western blot, immunofluorescence, reverse...
Cancer stem cells (CSCs) have recently been linked to new treatment strategies for gastric cancer due the critical role which they play as 'heartbeat' of cancer. In present study, we explored effects quercetin, an anti-inflammatory and antiviral compound, on CSCs (GCSCs). We noted that quercetin exerted pronounced inhibitory GCSC survival. Moreover, induced cell apoptosis in a mitochondrial-dependent manner, shown by reduction mitochondrial membrane potential, activation caspase-3 -9,...
Macrophage recruitment and pro-inflammatory differentiation are hallmarks of various diseases, including infection sepsis. Although studies suggest that mitochondria may regulate macrophage immune responses, it remains unclear whether mitochondrial mass affects differentiation. Here, we found lipopolysaccharide (LPS)-activated macrophages possess higher than resting cells. Therefore, this study aimed to explore the functional role molecular mechanisms increased in differentiated macrophages....
The outbreak of coronavirus disease 2019 (COVID-19) is caused by the infection severe acute respiratory syndrome 2 (SARS-CoV-2), which leads to disruption immune system, exacerbated inflammation, and even multiple organ dysfunction syndrome. Regulatory T cells (Tregs) are an important subpopulation that exert immunosuppressive effects. Recent studies have demonstrated number Tregs significantly reduced in COVID-19 patients, this reduction may affect patients on several aspects, such as...
Introduction Ischemic stroke is a leading cause of morbidity and mortality in older adults. Therefore, this study, we sought to understand the interplay between microbiota, gut, brain context Objective To determine whether gut microbiota from younger individuals promotes recovery through angiogenesis both elderly patients aged mice, explored changes correlation short-chain fatty acids (SCFAs) population. Then, altered microbiome mice by transplanting donors before inducing experimental...
2,3,5,4′‐Tetrahydroxystilbene‐2‐O‐ β ‐D‐glucoside (TSG), an important monomer extracted from Polygonum multiflorum, can prevent a number of inflammation associated chronic diseases. However, the mechanism involved in TSG inducing anti‐inflammatory role remains unclear. As inducible antioxidant enzyme, Heme oxygenase‐1 (HO‐1), is crucial for protecting mammalian cells against adverse stimuli. Here, we found that treatment strongly induces expression HO‐1 NRF2‐depended manner. Meanwhile,...
Diabetic is a major contributor to the unfavorable prognosis of ischemic stroke. However, intensive hypoglycemic strategies do not improve stroke outcomes, implying that diabetes may affect outcomes through other ways. Ferroptosis novel programmed cell death pathway associated with development and This study aimed investigate effect streptozotocin (STZ)-induced on ferroptosis after from immune perspective, provide theoretical foundation for clinical management in patients diabetes. The...
Aims Rheumatoid arthritis (RA), which mainly results from fibroblast-like synoviocyte (FLS) dysfunction, is related to oxidative stress. Advanced oxidation protein products (AOPPs), are proinflammatory mediators and a novel biomarker of stress, have been observed accumulate significantly in the serum RA patients. Here, we present first investigation effects AOPPs on RA-FLSs signalling pathway involved AOPP-induced inflammatory responses invasive behaviour. Methods We used different...
Japanese encephalitis virus (JEV), with neurotoxic and neuroinvasive properties, is the major cause of human viral in Asia. Although Guillain-Barré syndrome caused by JEV infections not frequent, a few cases have been reported recent years. To date, no existing animal model for JEV-induced peripheral nerve injury (PNI) has established, thus pathogenic mechanism clarified. Therefore, an urgently required to clarify correlation between infection PNI. In present study, we used GIb strain NX1889...
Obesity, diabetes and related metabolic disorders are among the top prevalent metabolism-related diseases with increasing threat to human health throughout world. Oleanolic acid (OA) is a natural triterpenoid an aglycone of many saponins possessing anti-diabetic, antioxidant, hypolipidemic anti-inflammatory activities. A nano-formulation OA was recently developed evaluate efficiency nano-OA in treatment insulin-resistance high fat fructose (HFF) diet-fed rats. This study further identified...
Abstract Objective Chlorine is a chemical threat agent that can be harmful to humans. Inhalation of high levels chlorine lead acute lung injury (ALI). Currently, there no satisfactory treatment, and effective antidote urgently needed. Pentoxifylline (PTX), methylxanthine derivative nonspecific phosphodiesterase inhibitor, widely used for the treatment vascular disorders. The present study was aimed investigate inhibitory effects PTX on chlorine-induced ALI in rats. Methods Adult male...