Qianqian Wu

ORCID: 0000-0003-4820-5235
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About
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Research Areas
  • Cerebrovascular and Carotid Artery Diseases
  • Atherosclerosis and Cardiovascular Diseases
  • Immune Cell Function and Interaction
  • Neonatal and fetal brain pathology
  • Cancer-related molecular mechanisms research
  • COVID-19 Clinical Research Studies
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Fetal and Pediatric Neurological Disorders
  • Digital Marketing and Social Media
  • Retinal and Optic Conditions
  • Tryptophan and brain disorders
  • Neuroscience and Neuropharmacology Research
  • Endometrial and Cervical Cancer Treatments
  • Intracerebral and Subarachnoid Hemorrhage Research
  • Adipokines, Inflammation, and Metabolic Diseases
  • Ubiquitin and proteasome pathways
  • Digital Games and Media
  • Cultural Industries and Urban Development
  • Consumer Behavior in Brand Consumption and Identification
  • Shoulder Injury and Treatment
  • Hip and Femur Fractures
  • Long-Term Effects of COVID-19
  • Neurological and metabolic disorders
  • MicroRNA in disease regulation
  • Immunotherapy and Immune Responses

Soochow University
2024

Nanjing Drum Tower Hospital
2024

Ningxia Medical University
2023-2024

Affiliated Hospital of North Sichuan Medical College
2024

Guangzhou Medical University
2022-2024

Shaanxi Normal University
2023

Second Hospital of Hebei Medical University
2019-2021

Shanghai Maritime University
2021

Hebei Medical University
2019-2021

Wenzhou Medical University
2021

The outbreak of coronavirus disease 2019 (COVID-19) is caused by the infection severe acute respiratory syndrome 2 (SARS-CoV-2), which leads to disruption immune system, exacerbated inflammation, and even multiple organ dysfunction syndrome. Regulatory T cells (Tregs) are an important subpopulation that exert immunosuppressive effects. Recent studies have demonstrated number Tregs significantly reduced in COVID-19 patients, this reduction may affect patients on several aspects, such as...

10.14336/ad.2021.0709 article EN cc-by Aging and Disease 2021-01-01

Dopamine (DA) profoundly modulates excitatory synaptic transmission and plasticity in the brain. In present study effects of SKF83959, selective agonist phosphatidylinositol (PI)-linked D(1) -like receptor, on were investigated rat hippocampus. SKF83959 (10-100 μM) reversibly suppressed field postsynaptic potential (fEPSP) elicited by stimulating Schaffer's collateral-commissural fibers CA1 area hippocampal slices. However, inhibition was not blocked receptor antagonist SCH23390, D(2)...

10.1002/jnr.22653 article EN Journal of Neuroscience Research 2011-05-02

Large-artery atherosclerotic (LAA) stroke is the most common subtype of ischemic stroke. However, risk factors for long-term outcomes LAA in elderly Chinese population have not been well-described. Therefore, we aimed to assess and at 3, 12, 36 months after onset among patients aged 60 years older. All consecutive ≥ were prospectively recruited from Dongying People's Hospital between January 2016 December 2018. The clinical features outcome data collected. Differences relationship assessed....

10.3389/fneur.2021.642426 article EN cc-by Frontiers in Neurology 2021-04-23

The coronavirus disease 2019 (COVID-19) has spread rapidly as a pandemic around the world. In addition to severe acute respiratory syndrome, more and studies have focused on complication of COVID-19, especially ischemic stroke. Here, we propose several pathophysiological processes possible mechanisms underlying stroke after COVID-19 for early prevention better treatment COVID-19-related

10.14336/ad.2021.0209 article EN cc-by Aging and Disease 2021-01-01

Abstract Background Atherosclerosis, characterized by abnormal arterial lipid deposition, is an age-dependent inflammatory disease and contributes to elevated morbidity mortality. Senescent foamy macrophages are considered be deleterious at all stages of atherosclerosis, while the underlying mechanisms remain largely unknown. In this study, we aimed explore senescence-related genes in diagnosis for atherosclerotic plaque progression. Methods The atherosclerosis-related datasets were...

10.1007/s00011-023-01817-w article EN cc-by Inflammation Research 2023-12-07

Myocardial ischemia/reperfusion (I/R) injury is a classic type of cardiovascular disease characterized by to cardiomyocytes leading different types cell death. The degree irreversible myocardial damage closely related age, and ferroptosis involved in cardiomyocyte damage. However, the mechanisms underlying regulation aging I/R are still unclear. present study aims explore mechanism piRNA ferroptosis. Using left anterior descending coronary artery ligation an rat model D-galactose-induced...

10.3724/abbs.2024024 article EN cc-by-nc-nd Acta Biochimica et Biophysica Sinica 2024-02-29

Abstract Aluminum adjuvants remain the most commonly used vaccine adjuvants. Being rather effective in triggering humoral immunity, however, aluminum usually show limited abilities activating cellular immunities. Herein, by adding manganese ions during preparation of adjuvant, a manganese‐modified (Mn‐Al) adjuvant is obtained, which can effectively stimulate both and immune responses. Such Mn‐Al enhance antigen adsorption promote internalization dendritic cells (DCs). Subsequently, released...

10.1002/adhm.202401675 article EN Advanced Healthcare Materials 2024-08-23

Strokes are devastating as there no current therapies to prevent long-term neurological deficits. Previous studies reported that cerebroprotein hydrolysate (CH) plays a role in neuronal protection acute phase after ischemic stroke, while the effects of CH upon brain plasticity and outcomes stroke still uncertain. To address these gaps, we assessed effect new hydrolysate, CH1, on gray white matter integrity well axonal late potential mechanisms.Adult male mice were subjected permanent distal...

10.2147/ndt.s289990 article EN cc-by-nc Neuropsychiatric Disease and Treatment 2020-12-01

Previous research has established that the oxidized low-density lipoprotein/β2-glycoprotein I/anti-β2-glycoprotein I antibody (oxLDL/β2GPI/anti-β2GPI) complex can stimulate macrophages to secrete molecules associated with atherosclerosis (AS), such as monocyte chemotactic protein 1 (MCP-1), tissue factor (TF), and tumor necrosis factor-α (TNF-α). This also enhances uptake of oxLDL, thereby accelerating foam cell formation through Toll-like receptor-4/nuclear kappa B (TLR4/NF-κB) pathway....

10.1002/iid3.70058 article EN cc-by Immunity Inflammation and Disease 2024-11-01

The earlier the detection of hip joint is discovered, better final result. purpose this study aimed to investigate fetal development using magnetic resonance imaging (MRI), so as alert clinicians possible abnormal during intrauterine life.Measurements 34 cadaver fetuses (68 hips) were obtained regarding acetabular width and depth, anterior bony index (ABAI), cartilaginous (ACAI), posterior (PBAI), (PCAI). standard values each measurement obtained, gestational age-measurement change trend...

10.3389/fsurg.2022.847135 article EN cc-by Frontiers in Surgery 2022-02-14

<title>Abstract</title> OBJECTIVE The purpose of this study was to systematically assess the occipital lobe grey and white matter volume Isolated ventriculomegaly foetuses with MRI follow up on neurodevelopment participants. Method used evaluate 37 IVM group control foetuses. in each foetal gyrus manually segmented compared, followed assessed infancy early childhood. Results Compared group, gray lobes increased incidence neurodevelopmental delay increased. Conclusions We tested hypothesis...

10.21203/rs.3.rs-3610594/v1 preprint EN cc-by Research Square (Research Square) 2023-11-23

Objective To evaluate the imaging characteristics of atypical teratoid/rhabdoid tumor (AT/RT) central nervous system(CNS), and to improve diagnostic ability disease. Methods The clinical findings 9 patients were retrospectively analyzed. There 5 male 4 female, ages 7 months years, median age was 1.4 years. MR enhancement studies obtained in all cases. One case had CT examination. Results The lesions seen brain 8 cases lumbosacral spinal cord one case. The tumors size varied from...

10.3760/cma.j.issn.1005-1201.2017.08.011 article EN Zhonghua fangshexian yixue zazhi 2017-08-10

A 67-year-old female developed breathing difficulty due to medullary dorsolateral infarction without lung disease, and used a ventilator assist breathing.However, she suffered sleep apnea after stopping the eventually died in sleep.We have considered this type of central Ondine's curse syndrome.Acquired is rare often secondary lesions medulla oblongata pontine brain, such as inflammation, tumor, stroke, trauma, surgery, demyelinating angioma, Leigh's Arnold-Chiari malformation,...

10.17303/jnnd.2019.5.201 article EN 2019-08-19

중국의 중소기업은 중국 경제성장의 중요한 버팀목 역할을 꾸준히 수행하고 있다. 전체기업중 중소기업이 차지하는 비율은 99%로 제품생산 비중은 국내 총 생산의 약 60%를 차지하고 대량의 일자리를 제공하고 있으며 특히 농촌의 노동력을 도시로 유입시켜 도시화 발전 및 경제성장에 중추적인 아울러 기업이 납부하는 세금의 절반을 납부하고 있으며, 기술혁신 산업과 신제품 개발사업에서 각각 75%와 80%를 기록하고 2020년 1월 우한에서 발생한 코로나19는 외식업, 관광업, 교통산업 등에 막대한 피해를 입히고 대다수 관련 기업들이 임대료, 임금지급, 대출금상환등 경제적 부담에 직면하고 중소기업들은 코로나19 상황에 대처하는 능력이 부족하고 금융자원에 한계를 보이고 있서 발생 이후 생산중단, 폐업 등의 직면해 이러한 사태가 지속된다면 중소기업 더 나아가 전체의 엄청난 영향을 줄 것으로 예측되고 최근 중앙의 각 부위원회는 기업 지원정책을 신속히 제정하여 발표하고 자금난과 경영난을 겪고...

10.21740/jas.2020.05.23.2.137 article KO THE JOURNAL OF ASIAN STUDIES 2020-05-31

This paper is aimed at analyzing the impact of COVID-19 on Chinese online video industry. The hypothesis that since people had more time to spend leisure during quarantine, industry should be positively affected. Using methods such as collecting data from consulting firm’s research reports, news events, and summarizing evidence security capital market I concluded pandemics did bring a short-term increase in people’s attention industry, opened up new opportunities for creative business...

10.18282/l-e.v9i2.1387 article EN Learning & Education 2020-11-10
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