A5101832266- Animal Nutrition and Physiology
- Phytase and its Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Single-cell and spatial transcriptomics
- Wildlife Ecology and Conservation
- Rice Cultivation and Yield Improvement
- Food Quality and Safety Studies
- Cell Image Analysis Techniques
- Immunotherapy and Immune Responses
- Nitrogen and Sulfur Effects on Brassica
- Rangeland and Wildlife Management
- Silkworms and Sericulture Research
- Phytoestrogen effects and research
- Polysaccharides and Plant Cell Walls
- Solar Radiation and Photovoltaics
- Plant Ecology and Taxonomy Studies
- Bird parasitology and diseases
- Ferroptosis and cancer prognosis
- Lymphoma Diagnosis and Treatment
- Mycotoxins in Agriculture and Food
- Biopolymer Synthesis and Applications
- Indoor Air Quality and Microbial Exposure
- Prostate Cancer Treatment and Research
- Microbial infections and disease research
- Crop Yield and Soil Fertility
Guiyang Medical University
2021-2023
Huazhong Agricultural University
2023
BGI Group (China)
2022-2023
Shenzhen Polytechnic
2004-2023
Nanjing Agricultural University
2023
Center of Hubei Cooperative Innovation for Emissions Trading System
2023
University of Illinois Urbana-Champaign
2016-2021
ShanghaiTech University
2021
Beijing Forestry University
2011
Elucidating the cellular organization of cerebral cortex is critical for understanding brain structure and function. Using large-scale single-nucleus RNA sequencing spatial transcriptomic analysis 143 macaque cortical regions, we obtained a comprehensive atlas 264 transcriptome-defined cell types mapped their distribution across entire cortex. We characterized layer region preferences glutamatergic, GABAergic, non-neuronal types, as well regional differences in cell-type composition...
Abstract Despite decades of intensive search for compounds that modulate the activity particular protein targets, a large proportion human kinome remains as yet undrugged. Effective approaches are therefore required to map massive space unexplored compound–kinase interactions novel and potent activities. Here, we carry out crowdsourced benchmarking predictive algorithms kinase inhibitor potencies across multiple families tested on unpublished bioactivity data. We find top-performing...
Abstract Global profile of gene expression at single-cell resolution remains to be determined for primates. Using a recently developed technology (“Stereo-seq”), we have obtained comprehensive spatial transcriptome map the whole-brain level cynomolgus monkeys, with ∼600 genes per cell 10 μm-thick coronal sections (up 15 cm 2 in size). Large-scale single-nucleus RNA-seq analysis ∼1 million cells helped identify types corresponding Stereo-seq profiles, providing 3-D type atlas monkey brain....
Large-scale pigeon farming in China is gradually increasing. However, studies on the basic nutritional requirements of breeding pigeons during lactation, which greatly influence productivity and economic benefits breeding, remain scanty. The objective this study was to determine optimal dietary energy/protein ratio for lactating summer. A total 576 pairs Mimas were randomly divided into 12 groups (n = 48 per treatment), each pair bred 4 squabs. two-way ANOVA design with different protein...
The nutritional requirements of breeding pigeons depend on their physiological period, pattern, and environmental conditions. Despite works reduced litter size in winter production to combat high mortality the poor welfare squabs, there are few studies related these pigeons. A total 432 pairs European Mimas were randomly divided into 9 groups which 3 crude protein (CP) levels (15, 16.5, 18%) metabolizable energy (ME) (12.2 MJ/kg, 12.4 12.6 MJ/kg) tested determine optimal "2 + 3" pattern....
Deoxynivalenol (DON) is a common toxin in grains and feeds, DON exposure triggers severe small intestinal injury inflammation, which harms the health of humans livestock. treatment leads to decrease Paneth cells, whereas role cells DON-induced poorly understood. We utilized dithizone (40 mg/kg) keep murine cell number at low level. The results showed that dithizone-mediated long-term disruption aggravated injury, stem (ISC) loss, microbiota disorder (2 mg/kg)-treated mice. Unexpectedly,...
The administration of mRNA-based tumour vaccines is considered a promising strategy in immunotherapy, although its application against kidney renal clear cell carcinoma (KIRC) still at infancy stage. purpose this study was to identify potential antigens and further select suitable patients for vaccination. Gene expression data clinical information were retrieved from Expression Omnibus (GEO) Cancer Genome Atlas (TCGA) databases. GEPIA2 used evaluate the prognostic value selected antigens....
<ns4:p>Reliable predictions on the risk and survival time of prostate cancer patients based their clinical records can help guide treatment provide hints about disease mechanism. The Cox regression is currently a commonly accepted approach for such tasks in applications. More complex methods, like ensemble approaches, have potential reaching better prediction accuracy at cost increased training difficulty worse result interpretability. Better performance specific data set may also be...
Abstract Deciphering patterns of connectivity between neurons in the brain is a critical step toward understanding function. Imaging-based neuroanatomical tracing identifies area-to-area or sparse neuron-to-neuron patterns, but with limited throughput. Barcode-based connectomics maps large numbers single-neuron projections, remains challenge for jointly analyzing single-cell transcriptomics. Here, we established rAAV2-retro barcode-based multiplexed method that simultaneously characterizes...