A5057523100- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Cancer therapeutics and mechanisms
- Plant nutrient uptake and metabolism
- HER2/EGFR in Cancer Research
- Insect and Pesticide Research
- Lung Cancer Diagnosis and Treatment
- Legume Nitrogen Fixing Symbiosis
- Insect Pest Control Strategies
- Rice Cultivation and Yield Improvement
- Advanced Breast Cancer Therapies
- PI3K/AKT/mTOR signaling in cancer
- Lymphoma Diagnosis and Treatment
- Echinoderm biology and ecology
- Liquid Crystal Research Advancements
- Body Composition Measurement Techniques
- Nanowire Synthesis and Applications
- Metastasis and carcinoma case studies
- Photochromic and Fluorescence Chemistry
- Photonic Crystals and Applications
- CAR-T cell therapy research
- Immune cells in cancer
- Insect-Plant Interactions and Control
Lanzhou University
2025
Nanjing Agricultural University
2023-2025
Sun Yat-sen University
2025
Sun Yat-sen University Cancer Center
2025
Academy of Military Medical Sciences
2012-2024
East China University of Science and Technology
2024
University of Illinois Urbana-Champaign
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2023
307th Hospital of Chinese People’s Liberation Army
2014-2019
Bayer (China)
2015
BackgroundAfatinib has demonstrated clinical benefit in patients with non-small-cell lung cancer progressing after treatment erlotinib/gefitinib. This phase III trial prospectively assessed whether continued irreversible ErbB-family blockade afatinib plus paclitaxel superior outcomes versus switching to chemotherapy alone acquiring resistance erlotinib/gefitinib and monotherapy.Patients methodsPatients relapsed/refractory disease following ≥1 line of chemotherapy, whose tumors had progressed...
Inwardly rectifying potassium (Kir) channels regulate essential physiological processes in insects and have been identified as potential targets for developing new insecticides. Flonicamid has reported to inhibit Kir channels, disrupting the functions of salivary glands renal tubules. However, precise molecular target flonicamid remains debated. It is unclear whether directly or acts on other sites involved activation transient receptor vanilloid (TRPV) channels. In this study, we observed...
Between the two major rice subspecies, indica varieties generally exhibit higher nitrate (NO3‒) uptake and nitrogen (N)-use efficiency (NUE) than japonica varieties. Introducing efficient NO3‒ utilization alleles from into could improve NUE, at same time uncover unknown regulators of metabolism. Here, we identify OsWRKY23 as a key regulator NUE differences between rice. The OsWRKY23indica allele exhibits reduced transcriptional activation negative auxin accumulation, DULL NITROGEN RESPONSE1...
Auxin has emerged as a crucial regulator of plant nitrogen (N)-use efficiency (NUE) through indirect effects on growth and development direct regulation N metabolism-related genes. We previously reported DULL NITROGEN RESPONSE1 (DNR1) an amino transferase that inhibits auxin accumulation negatively regulates rice (Oryza sativa) NUE grain yield. However, the identities molecular regulators acting upstream DNR1 await exploration. Our current work identifies SUPPRESSOR OF ON CHROMOSOME 5 (SOD5)...
Inwardly rectifying potassium channels (Kir) play a key role in regulating various physiological processes. However, the structural and pharmacological mechanisms of insect Kir remain unclear. In this study, we show that coexpression different subunits same tissue did not affect rectification properties strongly Kir. The inhibitor VU041, along with insecticide flonicamid its metabolite flumetnicam, were tested for their inhibitory effects on homotetrameric Kir1 Kir2 channels. Both from two...
Bone cancer pain remains a significant clinical challenge, often refractory to conventional treatments. The upregulation of the P2X3 receptor in dorsal root ganglia has been implicated pathogenesis bone pain. This study aimed elucidate role this context and assess therapeutic potential silencing. Utilizing rat model with Walker 256 cells simulate pain, researchers conducted molecular analyses, including semi-quantitative RT-PCR Western Blot, investigate expression ganglia. Results...
An active dual-stimulus responsive coloured cholesteric fibre that enables orthogonal modulation of reflection bands and reflectance by optical gaseous means, respectively.
This study focuses on analyzing the texture properties and bioelectrical impedance characteristics of frozen chicken breasts during low-temperature thawing, meanwhile, we also compared differences in physiochemical properties. Frozen were thawed at 4 ± 2°C for 2, 4, 6, 8, 10 h separately, then (color, pH, water-holding capacity, water distribution), (easy-to-cut level), determined analyzed. The easy-to-cut level samples was evaluated by sensory panel two indexes, one is Warner-Bratzler shear...
Abstract Metastatic breast cancers show variable clinical responses due to inherent heterogeneity, both within tumors and among patients. Studies mainly examine molecular diversity across different patients' genetic variance a single tumor. Yet, the variability multiple or metastases in patient remains underexplored. Our study investigates this intrapatient examining cell tumor evolution from source metastatic cancer. In warm procurement trial involving 6 patients with multi-site tumors,...
ABSTRACT Thanks to the growing interests in computer-aided synthesis planning (CASP), a wide variety of retrosynthesis and retrobiosynthesis tools have been developed past decades. However, for multi-step chemoenzymatic reactions are still rare despite widespread use enzymatic chemical synthesis. Herein we report reaction type score (RTscore)-guided (RTS-CESP) strategy. Briefly, RTscore is trained using text-based convolutional neural network (TextCNN) distinguish from decomposition evaluate...
Abstract In the current work, effect of surface phase structure silicon wafer on copper assisted chemical etching (Cu-ACE) behavior was investigated by adopting N-type monocrystal with different thickness as raw material. An inverted pyramid prepared method Cu-ACE, which exhibited a mild reaction temperature reflectance reaching low 6.34%. Furthermore, cetyltrimethylammonium bromide (CTAB) employed an additive to optimize Cu-ACE process. The study revealed that CTAB molecules could adsorb Cu...