A5000995506- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Vestibular and auditory disorders
- Noise Effects and Management
- Ion Channels and Receptors
- Neurogenesis and neuroplasticity mechanisms
- Biochemical Analysis and Sensing Techniques
- Polysaccharides and Plant Cell Walls
- Ocular Surface and Contact Lens
- Cardiac Valve Diseases and Treatments
- Frailty in Older Adults
- Plant Molecular Biology Research
- Multisensory perception and integration
- Aortic Disease and Treatment Approaches
- Neural dynamics and brain function
- Aortic aneurysm repair treatments
- Plant Stress Responses and Tolerance
- Plant Reproductive Biology
First Affiliated Hospital of Zhengzhou University
2023
Hebei Medical University
2023
Second Hospital of Hebei Medical University
2023
First Hospital of Qinhuangdao
2023
Yanshan University
2023
Jilin University
2019
Union Hospital
2019
Southeast University
2014-2016
Southeast University
2015
Institute of Genetics and Developmental Biology
2008
Hearing loss often triggers an inescapable buzz (tinnitus) and causes everyday sounds to become intolerably loud (hyperacusis), but exactly where how this occurs in the brain is unknown. To identify neural substrate for these debilitating disorders, we induced both tinnitus hyperacusis with ototoxic drug (salicylate) used behavioral, electrophysiological, functional magnetic resonance imaging (fMRI) techniques tinnitus–hyperacusis network. Salicylate depressed output of cochlea, vigorously...
Hidden hearing refers to the functional deficits in without deterioration sensitivity. This concept is proposed based upon recent finding of massive noise-induced damage on ribbon synapse between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) cochlea significant permanent threshold shifts (PTS). Presumably, such may cause coding auditory nerve fibers (ANFs). However, had not been detailed except that a selective loss ANFs with low spontaneous rate (SR) was reported. In present...
Abstract Hearing loss has been associated with cognitive decline in the elderly and is considered to be an independent risk factor for dementia. One of most common causes acquired sensorineural hearing exposure excessive noise, which found impair learning ability performance human subjects animal models. Noise also depress neurogenesis hippocampus. However, effect mainly attributed oxidant stress noise on brain. In present study, young adult CBA/CAJ mice (between 1.5 2 months age) were...
The neural mechanisms that give rise to the phantom sound of tinnitus are poorly understood. This study aims investigate whether aberrant spontaneous brain activity exists in chronic patients using resting-state functional magnetic resonance imaging (fMRI) technique. A total 31 with and 32 healthy age-, sex-, education-matched controls were prospectively examined. Both groups had normal hearing thresholds. We calculated amplitude low-frequency fluctuations (ALFFs) fMRI signals measure...
Recent evidence has shown that noise-induced damage to the synapse between inner hair cells (IHCs) and type I afferent auditory nerve fibers (ANFs) may occur in absence of permanent threshold shift (PTS), synapses connecting IHCs with low spontaneous rate (SR) ANFs are disproportionately affected. Due functional importance low-SR ANF units for temporal processing signal coding noisy backgrounds, deficits cochlear associated result significant difficulties hearing noise (i.e., "hidden loss")....
Subjective tinnitus is hypothesized to arise from aberrant neural activity; however, its bases are poorly understood. To identify networks involved in chronic tinnitus, we compared the resting-state functional magnetic resonance imaging (fMRI) patterns of patients and healthy controls. Resting-state fMRI measurements were obtained a group (n = 29) with normal hearing well-matched controls 30). Regional homogeneity (ReHo) analysis connectivity used abnormal brain these abnormalities distress....
Noise pollution is a major hazardous factor to human health and likely harmful for vulnerable groups such as pre-term infants under life-support system in an intensive care unit. Previous studies have suggested that noise exposure impairs children's learning ability cognitive performance functions animal models which the effect mainly attributed oxidant stress of on brain. The potential role induced hearing loss (NIHL), rather than stress, has also been indicated by depression neurogenesis...
Recently, ribbon synapses to the hair cells (HCs) in cochlea have become a novel site of interest investigation noise-induced cochlear lesions adult rodents (Kujawa and Liberman, 2009; Lin et al., 2011; Liu 2012; Shi 2013). Permanent damage this type synapse can result subsequent degeneration spiral ganglion neurons (SGNs) absence permanent changes hearing sensitivity. To verify whether noise exposure during an early developmental period produces similar impact on synapses, present study...
Purpose . Recent studies suggest that tinnitus may be due in part to aberrant callosal structure and interhemispheric interaction. To explore this hypothesis we use a novel method, voxel-mirrored homotopic connectivity (VMHC), examine the resting-state functional its relationships with clinical characteristics chronic patients. Materials Methods Twenty-eight patients normal hearing thresholds 30 age-, sex-, education-, threshold-matched healthy controls were included study underwent fMRI...
Developmental plasticity defines an adaptive mechanism, which plays a fundamental role in plant development and survival. How intrinsic or extrinsic factors are integrated to specify cell fates subsequent organ body building of is still poorly understood. By studying developmental Arabidopsis root hair response salt stress, we have begun understand more about the basis cellular plasticity. This paper summarizes our recent it described stress induced epidermis Arabidopsis. Analysis gene...
The transient receptor potential cation channel subfamily M member 8 (TRPM8) is a kind of non-selective which controls Ca2+ homeostasis. Mutations in TRPM8 were related to dry eye diseases (DED). Here we constructed knockout cell line WAe009-A-A from the original embryonic stem H9 using CRISPR/Cas9 technology, maybe helpful for exploring pathogenesis DED. cells possess morphology and pluripotency as well normal karyotype, have ability differentiating into three germ layers vitro.
Abstract Background: Some clinicians use endograft to partially cover the left subclavian artery (LSA) ostium or multilayer flow modulator (MFM) mitigate cases with an insufficient landing area in thoracic endovascular aortic repair(TEVAR) treatment. So we used computational fluid dynamics (CFD) study effects of two surgical methods on hemodynamics LSA, due they may affect long-term patency rate LSA. Methods: The digital model arch was established and named A, which only included supraarch...
Objective To explore the current status of frailty in elderly patients with chronic heart failure (CHF) , and influencing factors. Methods From January 2016 to December 2017, a total 190 inpatients CHF Cardiology Department China-Japan Union Hospital Jilin University were selected as participants by convenient sampling method, CP-FI-CGA questionnaire was used study. Results The scored (0.05-0.87) points an overall average score (0.32±0.10) points, indicating moderate level...