A5091174506- Neural dynamics and brain function
- Visual perception and processing mechanisms
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Retinal Development and Disorders
- Face Recognition and Perception
- Neuroscience and Neural Engineering
- Advanced Memory and Neural Computing
- Aesthetic Perception and Analysis
- Neural and Behavioral Psychology Studies
- Neurobiology and Insect Physiology Research
- Functional Brain Connectivity Studies
- Visual Attention and Saliency Detection
- Memory and Neural Mechanisms
- Advanced Chemical Sensor Technologies
- Advanced Fluorescence Microscopy Techniques
- Spatial Cognition and Navigation
- Receptor Mechanisms and Signaling
- Tactile and Sensory Interactions
- Multisensory perception and integration
- Neuroscience and Music Perception
- Analytical Chemistry and Sensors
- Child and Animal Learning Development
- Color perception and design
- Ocular and Laser Science Research
University of Colorado Denver
2023-2025
Max Planck Florida Institute for Neuroscience
2015-2023
University of Pennsylvania
2020-2023
Baylor College of Medicine
2023
California University of Pennsylvania
2021-2023
The University of Texas at Austin
2011-2022
Yale University
2010-2014
University of Oregon
2008-2010
Oregon Health & Science University
2009
Orientation selectivity is a property of mammalian primary visual cortex (V1) neurons, yet its emergence along the pathway varies across species. In carnivores and primates, elongated receptive fields first appear in V1, whereas lagomorphs such emerge earlier, retina. Here we examine mouse reveal existence orientation lateral geniculate nucleus (LGN) relay cells. Cortical inactivation does not reduce this selectivity, indicating that cortical feedback source. similar for LGN cells spiking...
Primary visual cortex (V1) is the site at which orientation selectivity emerges in mammals: thalamus afferents to V1 respond equally all stimulus orientations, whereas their target neurons selectively orientation. The emergence of has long served as a model for investigating cortical computation. Recent evidence mouse opens computation dissection by genetic and imaging tools, but also raises two essential questions: (1) How does compare with that previously described species? (2) What...
Signals from the two eyes are first integrated in primary visual cortex (V1). In many mammals, this binocular integration is an important step development of stereopsis, perception depth disparity. Neurons zone mouse V1 receive inputs both eyes, but it unclear how that information and whether has a function similar to found other mammals. Using extracellular recordings, we demonstrate neurons tuned for disparities, or spatial differences, between each eye, thus extracting signals potentially...
Sensory deafferentation results in rapid shifts the receptive fields of cortical neurons, but synaptic mechanisms underlying these changes remain unknown. The rapidity has led to suggestion that subthreshold inputs may be unmasked by a selective loss inhibition. To study this, we used vivo whole cell recordings directly measure tone-evoked excitatory and inhibitory auditory neurons before after acoustic trauma. Here report acute trauma disrupted balance excitation inhibition selectively...
In adulthood, sleep-wake rhythms are one of the most prominent behaviors under circadian control. However, during early life, sleep is spread across 24-hour day. The mechanism through which emerge, and consequent advantage conferred to a juvenile animal, unknown. second-instar Drosophila larvae (L2), like in human infants, not We identify precise developmental time point when clock begins regulate Drosophila, leading emergence third-instars (L3). At this stage, cellular connection forms...
Postsynaptic mitochondria are critical for the development, plasticity, and maintenance of synaptic inputs. However, their relationship to structure functional activity is unknown. We examined a correlative dataset from ferret visual cortex with in vivo two-photon calcium imaging dendritic spines during stimulation electron microscopy reconstructions spine ultrastructure, investigating mitochondrial abundance near functionally structurally characterized spines. Surprisingly, we found no...
Recent research in vision science, infant cognition, and word-learning all suggest a special role for the processing of individual discrete objects. But what counts as an object? Answers to this question often depend on contrasting object-based with spatial areas, or unbound visual features. In cognition word-learning, though, another salient contrast has been between rigid cohesive objects nonsolid substances. Whereas may move from one location another, substance must *pour* another. Here...
Visual disruption early in development dramatically changes how primary visual cortex neurons integrate binocular inputs. The is paradigmatic for investigating the synaptic basis of long-term cortical function, because site convergence. underlying alterations circuitry by remain poorly understood. Here we compare membrane potential responses, observed via whole-cell recordings vivo , normal adult cats with those which strabismus was induced before developmental critical period. In strabismic...
Abstract
Postsynaptic mitochondria are critical for the development, plasticity, and maintenance of synaptic inputs. However, their relationship to structure functional activity is unknown. We examined a correlative dataset from ferret visual cortex with in vivo two-photon calcium imaging dendritic spines during stimulation electron microscopy reconstructions spine ultrastructure, investigating mitochondrial abundance near functionally structurally characterized spines. Surprisingly, we found no...
Responses of cortical neurons to sensory stimuli within their receptive fields can be profoundly altered by the stimulus context. In visual and somatosensory cortex, contextual interactions have been shown change sign from facilitation suppression depending on strength. Contextual modulation high-contrast tends suppressive, but for low-contrast facilitative. This trade-off may optimize integration cells has suggested a general feature processing, it remains unknown whether similar phenomenon...
A tidal wave of recent research purports to have discovered that higher-level states such as moods, action-capabilities, and categorical knowledge can literally directly affect what we see. Are these truly effects on perception, or might some instead reflect influences judgment, memory, response bias? Here, exploit an infamous art-historical reasoning error (the so-called "El Greco fallacy") demonstrate in five experiments multiple alleged top-down (ranging from morality lightness perception...
Experiences during the critical period sculpt circuitry within neocortex, leading to changes in functional responses of sensory neurons. Monocular deprivation (MD) visual causes shifts ocular preference, or dominance, toward open eye primary cortex (V1) and disrupts normal development acuity. In carnivores primates, MD also emergence binocular disparity selectivity, a cue resulting from integrating inputs. This disruption may be result increase neurons driven exclusively by that follows...