A5005558102- Neuroscience and Neuropharmacology Research
- Memory and Neural Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Neural dynamics and brain function
- Poisoning and overdose treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Antibiotics Pharmacokinetics and Efficacy
- Adipose Tissue and Metabolism
- Polyamine Metabolism and Applications
- Epilepsy research and treatment
- 14-3-3 protein interactions
- Receptor Mechanisms and Signaling
- Neurogenesis and neuroplasticity mechanisms
- PI3K/AKT/mTOR signaling in cancer
- Mast cells and histamine
- Nicotinic Acetylcholine Receptors Study
- Tryptophan and brain disorders
- Retinal Development and Disorders
- Immune Cell Function and Interaction
The University of Texas at Austin
2012-2024
Austin College
2013
The central amygdala (CeA) contains a diverse population of cells, including multiple subtypes GABAergic neurons, along with glia and epithelial cells. Specific CeA cell types have been shown to affect alcohol consumption in animal models dependence may be involved negative during withdrawal. We used single-nuclei RNA sequencing determine cell-type specificity differential gene expression the induced by Cells within were classified using unbiased clustering analyses identified based on known...
A single injection of N-methyl-D-aspartate receptor (NMDAR) antagonists produces a rapid antidepressant response. Lasting changes in the synapse structure and composition underlie effectiveness these drugs. We recently discovered that antidepressants cause shift γ-aminobutyric acid (GABABR) signaling pathway, such GABABR activation shifts from opening inwardly rectifiying potassium channels (Kir/GIRK) to increasing resting dendritic calcium signal mammalian Target Rapamycin activity....
Many biological processes involve the mechanistic/mammalian target of rapamycin complex 1 (mTORC1). Thus, challenge deciphering mTORC1-mediated functions during normal and pathological states in central nervous system is challenging. Because mTORC1 at core translation, we have investigated function global regional protein expression. Activation has been generally regarded to promote translation. Few but recent works shown that suppression can also local synthesis. Moreover, excessive...
Background Ethanol ( E t OH ) affects prefrontal cortex functional roles such as decision making, working memory, and behavioral control. Yet, the pharmacological effect of on dopamine, a neuromodulator in medial (m PFC ), is unclear. Past studies exploring this topic produced conflicting outcomes; however, handful factors (temporal resolution, method drug administration, estrous cycle) possibly contributed to these discrepancies. We sought mitigate order elucidate 's effects mPFC dopamine L...
Background Medial prefrontal cortex (m PFC ) dysfunction is present in heavy alcohol consumers. Dopamine signaling m associated with executive functioning and affects drinking behavior; however, direct measurement of extracellular dopamine during appetitive consummatory ethanol (EtOH) self‐administration behavior has not been reported. Methods We used vivo microdialysis freely behaving, adult, male, Long Evans rats to determine concentration the operant an EtOH‐plus‐sucrose or sucrose...
Operant self-administration methods are commonly used to study the behavioral and pharmacological effects of many drugs abuse, including ethanol. However, ethanol is typically self-administered orally, rather than intravenously like other abuse. The pharmacokinetics orally administered more complex drugs. Because understanding relationship between requires knowledge time course reaching brain during after drinking, we use in vivo microdialysis gas chromatography with flame ionization...
Operant self-administration methods are commonly used to study the behavioral and pharmacological effects of many drugs abuse, including ethanol. However, ethanol is typically self-administered orally, rather than intravenously like other abuse. The pharmacokinetics orally administered more complex drugs. Because understanding relationship between requires knowledge time course reaching brain during after drinking, we use in vivo microdialysis gas chromatography with flame ionization...