A5085597699- Neural dynamics and brain function
- Visual perception and processing mechanisms
- Retinal Development and Disorders
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Anesthesia and Neurotoxicity Research
- Memory and Neural Mechanisms
- Neurobiology and Insect Physiology Research
- Plant and Biological Electrophysiology Studies
- EEG and Brain-Computer Interfaces
- Olfactory and Sensory Function Studies
- Multisensory perception and integration
- Neurogenesis and neuroplasticity mechanisms
The University of Texas at Austin
2015-2024
Viral vectors enable foreign proteins to be expressed in brains of non-genetic species, including non-human primates. However, viruses targeting specific neuron classes have proved elusive. Here we describe viral promoters and strategies for accessing GABAergic interneurons their molecularly defined subsets the rodent primate. Using a set intersection approach, which relies on two co-active promoters, can restrict heterologous protein expression cortical hippocampal somatostatin-positive...
The connectivity principles underlying the emergence of orientation selectivity in primary visual cortex (V1) mammals lacking an map (such as rodents and lagomorphs) are poorly understood. We present a computational model which random gives rise to that matches experimental observations. predicts mouse V1 neurons should exhibit intricate receptive fields two-dimensional frequency domain, causing shift preferences with spatial frequency. find evidence for these features using calcium imaging...
Experiences during the critical period sculpt circuitry within neocortex, leading to changes in functional responses of sensory neurons. Monocular deprivation (MD) visual causes shifts ocular preference, or dominance, toward open eye primary cortex (V1) and disrupts normal development acuity. In carnivores primates, MD also emergence binocular disparity selectivity, a cue resulting from integrating inputs. This disruption may be result increase neurons driven exclusively by that follows...
Mammalian neocortical circuits are functionally organized such that the selectivity of individual neurons systematically shifts across cortical surface, forming a continuous map. Maps sensory space exist in cortex, as retinotopic maps visual system or tonotopic auditory system, but other functional response properties also may be similarly organized. For example, many carnivores and primates possess map for orientation primary cortex (V1), whereas mice, rabbits, gray squirrel lack maps. In...
Abstract Ocular following eye movements help stabilize images on the retina and offer a window to study motion interpretation by visual circuits. We use these ocular integration behavior in marmosets. characterize responses marmosets using different moving stimuli such as dot patterns, gratings, plaids. Marmosets track along directions exhibit spatial frequency speed sensitivity, which closely matches sensitivity reported neurons from their motion-selective area MT. are also able integrated...
Abstract Sensory cortex amplifies relevant features of external stimuli. This sensitivity and selectivity arise through the transformation inputs by cortical circuitry. We characterize circuit mechanisms dynamics amplification making large-scale simultaneous measurements single cells in awake primates testing computational models. By comparing network activity both driven spontaneous states with models, we identify as operating a regime balanced amplification. Incoming are strongly but...
ABSTRACT Animals use a combination of eye movements to track moving objects. These different need be coordinated for successful tracking, requiring interactions between the systems involved. Here, we study interaction saccadic and smooth pursuit movement in marmosets. Using single target task, show that saccades cause an enhancement following saccade. two-target this is selective towards motion selected by saccade, irrespective any biases prior experiments highlight similarities functioning...
Animals use a combination of eye movements to track moving objects. These different need be coordinated for successful tracking, requiring interactions between the systems involved. Here, we study interaction saccadic and smooth pursuit movement in marmosets. Using single-target task, show that saccades cause an enhancement following saccade. two-target this is selective toward motion target selected by saccade, irrespective any biases prior experiments highlight similarities functioning...
Abstract Cortical neurons are characterized by their variable spiking patterns. We challenge prevalent theories for the origin of variability. examine specific hypothesis that cortical synchrony drives variability in vivo . Using dynamic clamp, we demonstrate intrinsic neuronal properties do not contribute substantially to variability, but rather emerges from weakly synchronous network drive. With large-scale electrophysiology quantify degree and its time scale networks physiological levels...
We describe a chamber system to perform imaging, electrophysiology and optogenetic stimulation in awake anaesthetized marmosets. developed this low-profile design be able access the underlying tissue when needed, or leave it sealed for long periods. Such accessibility is useful maintain clarity as well viral drug injections at different time points. The flexible either optical electrophysiological recording can performed same by exchanging inserts. provides an easy approach day-to-day stable...
Abstract Ocular following eye movements help stabilize images on the retina and offer a window to study motion interpretation by visual circuits. We use these ocular integration behavior in marmosets. characterize responses marmosets using different moving stimuli such as dot patterns, gratings, plaids. The can accurately track along directions exhibit spatial frequency speed sensitivity that closely matches reported neurons from their selective area MT. Marmosets are also able integrated of...
Summary We study the connectivity principles underlying emergence of orientation selectivity in primary visual cortex (V1) mammals lacking an map. present a computational model which random gives rise to that matches experimental observations. It predicts mouse V1 neurons should exhibit intricate receptive fields two-dimensional frequency domain, causing shift preferences with spatial frequency. find evidence for these features using calcium imaging and intracellular whole cell recordings.