A5024283351- Neural dynamics and brain function
- Hearing, Cochlea, Tinnitus, Genetics
- Neurobiology and Insect Physiology Research
- Neuroscience and Neuropharmacology Research
- Advanced Chemical Sensor Technologies
- Animal Vocal Communication and Behavior
- Plant and Biological Electrophysiology Studies
- Neuroscience and Music Perception
- Healthcare Technology and Patient Monitoring
- Anesthesia and Neurotoxicity Research
- Neurogenesis and neuroplasticity mechanisms
- Noise Effects and Management
- Neuropeptides and Animal Physiology
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Hearing Loss and Rehabilitation
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Regulation of Appetite and Obesity
- Vestibular and auditory disorders
Harvard University
2024-2025
The University of Texas at Austin
2019-2021
University of Maryland, College Park
2012-2014
Central amygdala (CeA) neurons that produce corticotropin-releasing factor (CRF) regulate anxiety and fear learning. These CeACRF release GABA several neuropeptides predicted to play important yet opposing roles in these behaviors. We dissected the relative of GABA, CRF, dynorphin, neurotensin learning by disrupting their expression using RNAi male rats. but not or neurotensin, regulates baseline anxiety-like behavior. In contrast, chemogenetic stimulation evokes behavior dependent on CRF...
Viral vectors enable foreign proteins to be expressed in brains of non-genetic species, including non-human primates. However, viruses targeting specific neuron classes have proved elusive. Here we describe viral promoters and strategies for accessing GABAergic interneurons their molecularly defined subsets the rodent primate. Using a set intersection approach, which relies on two co-active promoters, can restrict heterologous protein expression cortical hippocampal somatostatin-positive...
Animals navigate the auditory world by recognizing complex sounds, from rustle of a predator to call potential mate. This ability depends in part on octopus cells brainstem, which respond multiple frequencies that change over time, as occurs natural stimuli. Unlike average neuron, integrates inputs time order tens milliseconds, must detect momentary coincidence excitatory cochlea during an ongoing sound both millisecond and submillisecond scale. Here, we show receive inhibitory their...
Animals navigate the auditory world by recognizing complex sounds, from rustle of a predator to call potential mate. This ability depends in part on octopus cells brainstem, which respond multiple frequencies that change over time, as occurs natural stimuli. Unlike average neuron, integrates inputs time order tens milliseconds, must detect momentary coincidence excitatory cochlea during an ongoing sound both millisecond and submillisecond scale. Here, we show receive inhibitory their...
Animals navigate the auditory world by recognizing complex sounds, from rustle of a predator to call potential mate. This ability depends in part on octopus cells brainstem, which respond multiple frequencies that change over time, as occurs natural stimuli. Unlike average neuron, integrates inputs time order tens milliseconds, must detect momentary coincidence excitatory cochlea during an ongoing sound both millisecond and submillisecond scale. Here, we show receive inhibitory their...
Significance Our ability to identify sounds and understand communication signals depends upon our brains’ capacity combine information about diverse sound features, including temporal patterns. The central nucleus of the inferior colliculus (ICC) performs an initial stage this integration, but a circuit-based understanding these processes has been hampered by difficulties in separating clearly defined functional cell types. Here we characterize major excitatory projection neuron ICC. These...
Reliable representation of the spectrotemporal features an acoustic stimulus is critical for sound recognition. However, if all neurons respond with identical firing to same stimulus, redundancy in activity patterns would reduce information capacity population. We thus investigated spike reliability and temporal fluctuation coding ensemble recorded vitro from avian auditory brain stem. Sequential patch-clamp recordings were made cochlear nucleus angularis while injecting filtered Gaussian...
The intrinsic properties of tonically firing neurons in the cochlear nucleus contribute to representing average sound intensity by favoring synaptic integration across auditory nerve inputs, reducing phase locking fine temporal acoustic structure and enhancing envelope locking. To determine whether avian angularis (NA) resemble ideal integrators, we investigated their responses noisy current injections during whole cell patch-clamp recordings brain slices. One subclass (36% neurons, mainly...
Animals navigate the auditory world by recognizing complex sounds, from rustle of a predator to call potential mate. This ability depends in part on octopus cells brainstem, which respond multiple frequencies that change over time, as occurs natural stimuli. Unlike average neuron, integrates inputs time order tens milliseconds, must detect momentary coincidence excitatory cochlea during an ongoing sound both millisecond and submillisecond scale. Here, we show receive inhibitory their...
Animals navigate the auditory world by recognizing complex sounds, from rustle of a predator to call potential mate. This ability depends in part on octopus cells brainstem, which respond multiple frequencies that change over time, as occurs natural stimuli. Unlike average neuron, integrates inputs time order tens milliseconds, must detect momentary coincidence excitatory cochlea during an ongoing sound both millisecond and submillisecond scale. Here, we show receive inhibitory their...