Abstract The cortex modulates activity in superior colliculus via a direct projection. What is largely unknown whether (and if so how) the cortex. Here, we investigate this issue and show that optogenetic activation of changes input–output relationship neurons somatosensory cortex, enhancing responses to low amplitude whisker deflections. While there no pathway from found drives spiking posterior medial (POm) nucleus thalamus powerful monosynaptic pathway. Furthermore, POm receiving input...

Animals navigate the auditory world by recognizing complex sounds, from rustle of a predator to call potential mate. This ability depends in part on octopus cells brainstem, which respond multiple frequencies that change over time, as occurs natural stimuli. Unlike average neuron, integrates inputs time order tens milliseconds, must detect momentary coincidence excitatory cochlea during an ongoing sound both millisecond and submillisecond scale. Here, we show receive inhibitory their...

Summary How binocular visual information is combined at the level of single neurons in brain not fully understood. Here, we show mice that callosal input from opposite cortex (V1) plays a critical role this process. In vivo find projection carries ipsilateral eye and synapses exclusively onto neurons. Using presence to identify vitro, cellular are less excitable than monocular due high expression Kv1 potassium channels. At circuit only send projections V1, whereas do not. Finally, using...

Animals navigate the auditory world by recognizing complex sounds, from rustle of a predator to call potential mate. This ability depends in part on octopus cells brainstem, which respond multiple frequencies that change over time, as occurs natural stimuli. Unlike average neuron, integrates inputs time order tens milliseconds, must detect momentary coincidence excitatory cochlea during an ongoing sound both millisecond and submillisecond scale. Here, we show receive inhibitory their...

Theoretical and computational frameworks for synaptic plasticity learning have a long cherished history, with few parallels within the well-established literature of voltage-gated ion channels. In this study, we derive rules in hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, assess synergy between HCN channel establishing stability during learning. To do this, employ conductance-based model hippocampal pyramidal neuron, incorporate through Bienenstock-Cooper-Munro...

Abstract The capacity of the brain to encode multiple types sensory input is key survival. Yet, how neurons integrate information from pathways and what extent this influences behavior largely unknown. Using two-photon Ca 2+ imaging, optogenetics electrophysiology in vivo vitro, we report influence auditory on encoding somatosensory cortex show its impact goal-directed behavior. Monosynaptic enhanced dendritic somatic tactile stimulation layer 2/3 (L2/3), but not 5 (L5), pyramidal forepaw...

Unlike synaptic strength, intrinsic excitability is assumed to be a stable property of neurons. For example, learning somatic conductances generally not incorporated into computational models, and the discharge pattern neurons in response test stimuli frequently used as basis for phenotypic classification. However, it increasingly evident that signal processing properties are more plastic on timescale minutes. Here we demonstrate firing patterns CA3 rat hippocampus vitro undergo rapid...

Dendritic excitability regulates how neurons integrate synaptic inputs and thereby influences neuronal output. As active dendritic events are associated with significant calcium influx they likely to be modulated by calcium-dependent processes, such as calcium-activated potassium channels. Here we investigate the impact of small conductance channels (SK channels) on in male female rat cortical pyramidal vitro vivo . Using local applications SK channel antagonist apamin , show that blocking...

The superior colliculus is a critical brain region involved in processing visual information. It receives input directly from the retina, as well via projection primary cortex. Here we determine which cell types superficial receive cortex mice. Neurons layers of were classified into four groups - Wide-field, narrow-field, horizontal and stellate based on their morphological electrophysiological properties. To functional connections between V1 these different expressed Channelrhodopsin2 then...

Abstract The cortex sends a direct projection to the superior colliculus. What is largely unknown whether (and if so how) colliculus modulates activity in cortex. Here, we directly investigate this issue, showing that optogenetic activation of changes input-output relationship neurons somatosensory during whisker movement, enhancing responses low amplitude deflections. While there no pathway from cortex, found drives spiking posterior medial (POm) nucleus thalamus via powerful monosynaptic...

Animals navigate the auditory world by recognizing complex sounds, from rustle of a predator to call potential mate. This ability depends in part on octopus cells brainstem, which respond multiple frequencies that change over time, as occurs natural stimuli. Unlike average neuron, integrates inputs time order tens milliseconds, must detect momentary coincidence excitatory cochlea during an ongoing sound both millisecond and submillisecond scale. Here, we show receive inhibitory their...

Animals navigate the auditory world by recognizing complex sounds, from rustle of a predator to call potential mate. This ability depends in part on octopus cells brainstem, which respond multiple frequencies that change over time, as occurs natural stimuli. Unlike average neuron, integrates inputs time order tens milliseconds, must detect momentary coincidence excitatory cochlea during an ongoing sound both millisecond and submillisecond scale. Here, we show receive inhibitory their...

Abstract Unlike synaptic strength, intrinsic excitability is assumed to be a stable property of neurons. For example, learning somatic conductances generally not incorporated into computational models, and the discharge pattern neurons in response test stimuli frequently used as basis for phenotypic classification. However, it increasingly evident that signal processing properties are more plastic on timescale minutes. Here we demonstrate firing patterns CA3 rat hippocampus vitro undergo...

Neurons receive synaptic input primarily onto their dendrites. While we know much about the electrical properties of dendrites in rodents, have only just started to describe human brain. Here investigate capacity neurons generate NMDA spikes. We find that dendritic iontophoresis glutamate, as well local stimulation, can evoke spikes layer 2/3 pyramidal neurons. However, was significantly reduced compared rodent Simulations morphologically realistic and simplified models indicated a higher...

Summary Neurons receive synaptic input primarily onto their dendrites. While we know much about the electrical properties of dendrites in rodents, have only just started to describe human brain. Here investigate capacity neurons generate NMDA spikes. We find that dendritic iontophoresis glutamate, as well local stimulation, can evoke spikes layer 2/3 pyramidal neurons. Surprisingly, however, was significantly reduced compared rodent Simulations morphologically realistic models indicated a...