A5047943479- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Visual perception and processing mechanisms
- Retinal Development and Disorders
- Advanced Memory and Neural Computing
- Neuroscience and Neural Engineering
- Molecular spectroscopy and chirality
- Functional Brain Connectivity Studies
- Educational and Psychological Assessments
- Mitochondrial Function and Pathology
- Computational Drug Discovery Methods
- Reflective Practices in Education
- Graphite, nuclear technology, radiation studies
- Neurobiology and Insect Physiology Research
- Advanced Chemical Sensor Technologies
Max Planck Florida Institute for Neuroscience
2019-2024
Baylor College of Medicine
2023
University of Pennsylvania
2023
University of Maine at Farmington
2013
Postsynaptic mitochondria are critical for the development, plasticity, and maintenance of synaptic inputs. However, their relationship to structure functional activity is unknown. We examined a correlative dataset from ferret visual cortex with in vivo two-photon calcium imaging dendritic spines during stimulation electron microscopy reconstructions spine ultrastructure, investigating mitochondrial abundance near functionally structurally characterized spines. Surprisingly, we found no...
Abstract
Postsynaptic mitochondria are critical for the development, plasticity, and maintenance of synaptic inputs. However, their relationship to structure functional activity is unknown. We examined a correlative dataset from ferret visual cortex with in vivo two-photon calcium imaging dendritic spines during stimulation electron microscopy reconstructions spine ultrastructure, investigating mitochondrial abundance near functionally structurally characterized spines. Surprisingly, we found no...
Abstract Most excitatory synapses in the mammalian brain are contacted or ensheathed by astrocyte processes, forming tripartite synapses. Astrocytes thought to be critical regulators of structural and functional dynamics While degree synaptic coverage astrocytes is known vary across regions animal species, reason for implications this variability remains unknown. Further, how relates vivo properties individual has not been investigated. Here, we characterized pyramidal neurons ferret visual...
Abstract Single neocortical neurons are driven by populations of excitatory inputs, forming the basis neural selectivity to features sensory input. Excitatory connections thought mature during development through activity-dependent Hebbian plasticity 1 , whereby similarity between presynaptic and postsynaptic activity selectively strengthens some synapses weakens others 2 . Evidence in support this process ranges from measurements synaptic ultrastructure slice vivo physiology imaging studies...
Most excitatory synapses in the mammalian brain are contacted by astrocytes, forming tripartite synapse. This interface is thought to be critical for glutamate turnover and structural or functional dynamics of synapses. While degree synaptic contact astrocytes known vary across regions animal species, implications this variability remain unknown. Furthermore, precisely how astrocyte coverage relates
Postsynaptic mitochondria are critical to the development, plasticity, and maintenance of synaptic inputs. However, their relationship structure functional activity is unknown. We examined a correlative dataset from ferret visual cortex with in vivo two-photon calcium imaging dendritic spines during stimulation electron microscopy (EM) reconstructions spine ultrastructure, investigating mitochondrial abundance near functionally- structurally-characterized spines. Surprisingly, we found no...
Postsynaptic mitochondria are critical to the development, plasticity, and maintenance of synaptic inputs. However, their relationship structure functional activity is unknown. We examined a correlative dataset from ferret visual cortex with in vivo two-photon calcium imaging dendritic spines during stimulation electron microscopy (EM) reconstructions spine ultrastructure, investigating mitochondrial abundance near functionally- structurally-characterized spines. Surprisingly, we found no...
Postsynaptic mitochondria are critical to the development, plasticity, and maintenance of synaptic inputs. However, their relationship structure functional activity is unknown. We examined a correlative dataset from ferret visual cortex with in vivo two-photon calcium imaging dendritic spines during stimulation electron microscopy (EM) reconstructions spine ultrastructure, investigating mitochondrial abundance near functionally- structurally-characterized spines. Surprisingly, we found no...
Abstract In the visual system, signals from two eyes are combined to form a coherent representation through convergence of synaptic input populations onto individual cortical neurons. As synapses originate either monocular (representing one eye) or binocular both eyes) networks, it has been unclear how these inputs integrated coherently. Here, we imaged dendritic spines on layer 2/3 cells in ferret cortex with vivo two-photon microscopy examine and networks contribute interocular alignment...
In the visual system, signals from two eyes are combined to form a coherent representation through convergence of synaptic input populations onto individual cortical neurons. As synapses originate either monocular (representing one eye) or binocular both eyes) networks, it has been unclear how these inputs integrated coherently. Here, we imaged dendritic spines on layer 2/3 cells in ferret cortex with vivo two-photon microscopy examine and networks contribute interocular alignment...