A5049740740- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Corneal Surgery and Treatments
- Retinal Development and Disorders
- Corneal surgery and disorders
- Retinal Imaging and Analysis
- Ophthalmology and Visual Impairment Studies
- Hearing, Cochlea, Tinnitus, Genetics
- Ocular Surface and Contact Lens
- Retinopathy of Prematurity Studies
- Retinal and Optic Conditions
- Ocular Diseases and Behçet’s Syndrome
- RNA regulation and disease
- CRISPR and Genetic Engineering
- Ocular Disorders and Treatments
- Nasal Surgery and Airway Studies
- Ocular Infections and Treatments
- bioluminescence and chemiluminescence research
- Glutathione Transferases and Polymorphisms
- Photoreceptor and optogenetics research
- Intraocular Surgery and Lenses
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Health and Medical Research Impacts
- Sexual Differentiation and Disorders
- Advanced Glycation End Products research
Jaeb Center for Health Research
2016-2025
Foundation Fighting Blindness
2022
University of Mississippi Medical Center
2019
Research Network (United States)
2016
SAS Institute (United States)
2016
National Eye Institute
2015
Eye Bank Association of America
2015
The relative efficacy and safety of intravitreous aflibercept, bevacizumab, ranibizumab in the treatment diabetic macular edema are unknown.
The prevalence of persistent diabetic macular edema (DME) after months anti-vascular endothelial growth factor therapy and its effect on visual acuity are unknown.
Purpose: The Foundation Fighting Blindness (FFB) Consortium is a collaboration of 41 international clinical centers that manage patients affected with inherited retinal diseases (IRDs). annual gene poll was initiated in 2020 to capture the genetic cause disease IRD and associated practices sites. Data from 2022 are reported here. Methods: In 2022, academic, private practice, government ophthalmology clinics members were polled identify per-case causality list 387 syndromic nonsyndromic...
The aim of this study was to describe the aims, methods, donor and recipient cohort characteristics, potential impact Cornea Preservation Time Study (CPTS).The CPTS is a randomized clinical trial conducted at 40 sites (70 surgeons) designed assess effect cornea preservation time (PT) on graft survival 3 years after Descemet stripping automated endothelial keratoplasty (DSAEK). Eyes undergoing surgery for Fuchs corneal dystrophy or pseudophakic/aphakic edema were receive corneas stored ≤7...
To treat unilateral limbal stem cell (LSC) deficiency, we developed cultivated autologous epithelial cells (CALEC) using an innovative xenobiotic-free, serum-free, antibiotic-free, two-step manufacturing process for LSC isolation and expansion onto human amniotic membrane with rigorous quality control in a good practices facility. Limbal biopsies were used to generate CALEC constructs, final grafts evaluated by noninvasive scanning microscopy tested viability sterility. Cultivated maintained...
<h3>Importance</h3> Demonstrating that success of Descemet stripping automated endothelial keratoplasty is similar across donor cornea preservation times (PTs) could increase the pool. <h3>Objective</h3> To determine whether 3-year rate graft using corneal tissue preserved 8 to 14 days noninferior 7 or less. <h3>Design, Setting, and Participants</h3> A multicenter, double-masked, randomized noninferiority clinical trial was conducted from April 16, 2012, June 5, 2017, at 40 sites (70...
Demonstrating that endothelial cell loss following Descemet stripping automated keratoplasty (DSAEK) is independent of donor cornea preservation time (PT) could increase the pool corneal tissue available for keratoplasty.To determine whether 3 years after successful DSAEK related to PT.A multicenter, double-masked, randomized clinical trial included 40 sites (70 surgeons) in United States, with corneas provided by 23 US eye banks. A total 945 eyes 769 participants were Cornea Preservation...
Post hoc analyses from the Diabetic Retinopathy Clinical Research Network randomized clinical trial comparing aflibercept, bevacizumab, and ranibizumab for diabetic macular edema (DME) might influence interpretation of study results.
Purpose: The purpose of this study was to evaluate baseline best corrected visual acuity (BCVA), full-field electroretinography (ERG), stimulus thresholds (FST), and their relationship with demographic clinical characteristics in the Rate Progression Usher syndrome type 2 (USH2A)-related Retinal Degeneration (RUSH2A) multicenter study. Methods: Participants had (USH2, N = 80) or autosomal recessive nonsyndromic retinitis pigmentosa (ARRP, 47) associated biallelic variants USH2A gene....
Purpose: The purpose of this study was to evaluate self-reported functional vision (FV) and the impact loss in patients with USH2A-associated retinal degeneration using a patient-reported outcome (PRO) measure, Michigan Retinal Degeneration Questionnaire (MRDQ), correlate MRDQ scores well-established visual function measurements. Design: An observational cross-sectional (n = 93) participants who had Usher Syndrome Type 2 (USH2, n 55) or autosomal recessive non-syndromic retinitis pigmentosa...
Purpose: To describe 1-year changes in the cornea as assessed by anterior segment optical coherence tomography (AS-OCT) and vivo confocal microscopy (IVCM) for participants receiving a tissue graft generated from new manufacturing process using cultivated autologous limbal epithelial cells. Methods: Cultivated cell grafts were produced 2-stage following good process-compliant protocol. AS-OCT IVCM completed at baseline 12 months after treatment subsets of these participants. Secondary...
<h3>Importance</h3> Determining factors associated with endothelial cell loss after Descemet stripping automated keratoplasty (DSAEK) could improve long-term graft survival. <h3>Objective</h3> To evaluate the associations of donor, recipient, and operative density (ECD) 3 years DSAEK in Cornea Preservation Time Study. <h3>Design, Setting, Participants</h3> This cohort study was a secondary analysis data collected multicenter, double-masked, randomized clinical trial. Forty US sites 70...
We assessed genotype-phenotype correlations among the visual, auditory, and olfactory phenotypes of 127 participants with Usher syndrome (USH2) (n =80) or nonsyndromic autosomal recessive retinitis pigmentosa (ARRP) = 47) due to USH2A variants, using clinical data molecular diagnostics from Rate Progression in Related Retinal Degeneration (RUSH2A) study. truncating alleles were associated USH2 had a dose-dependent effect on hearing loss severity no visual within subgroup. A group missense an...
Purpose: To assess donor rim culture results and outcomes of ocular infections in the Cornea Preservation Time Study (CPTS). Methods: Donor corneal cultures were optional. characteristics assessed for association with positive using Fisher exact test Poisson regression analyses. Incidence rates estimated, 95% confidence intervals calculated. Results: Cultures performed 784 (58.9%) 1330 cases. For 0 to 7-day versus 8 14-day preservation time groups, respectively, fungal growth occurred 10 397...
Optimization of glycemic control is critical to reduce the number diabetes mellitus-related complications, but long-term success challenging. Although vision loss among greatest fears individuals with diabetes, comprehensive personalized education and risk assessments are not consistently used in ophthalmologic settings.