A5045956090- vaccines and immunoinformatics approaches
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Viral gastroenteritis research and epidemiology
- Dietary Effects on Health
- Regulation of Appetite and Obesity
- Viral Infections and Vectors
- Genetic factors in colorectal cancer
- Animal Disease Management and Epidemiology
- Viral Infections and Outbreaks Research
- Diverse Scientific and Economic Studies
- Viral Infections and Immunology Research
- T-cell and B-cell Immunology
- Sirtuins and Resveratrol in Medicine
- TGF-β signaling in diseases
- Cancer Immunotherapy and Biomarkers
- Metabolism, Diabetes, and Cancer
- Pancreatic and Hepatic Oncology Research
WuXi AppTec (China)
2024
State Key Laboratory of Virology
2019-2021
Wuhan University
2018-2021
T-cell recognition of somatic mutation-derived cancer neoepitopes can lead to tumor regression. Due the difficulty identify effective neoepitopes, constructing a database for sharing experimentally validated neoantigens will be beneficial precise immunotherapy. Meanwhile, routine neoepitope prediction in silico is important but laborious clinical use. Here we present NEPdb, that contains more than 17,000 human immunogenic and ineffective within leukocyte antigens (HLAs) via curating...
TGF-β has been demonstrated to promote tumor metastasis, and the regulatory mechanisms are poorly understood. Here, we report role of USP2a in promoting metastasis by facilitating TGF-β-triggered signaling. interacts with TGFBR1 TGFBR2 upon stimulation removes K33-linked polyubiquitin chains from Lys502 TGFBR1, recruitment SMAD2/3. Simultaneously, phosphorylates Ser207/Ser225 USP2a, leading disassociation SMAD2/3 TGFBR1. The phosphorylation SMAD2 is positively correlated human biopsies,...
Ebola virus (EBOV) is a non-segmented, negative-sense RNA (NNSV) in the family Filoviridae, and recognized as one of most lethal pathogens planet. For viruses, cellular or virus-encoded helicases play pivotal roles viral life cycles by remodelling structures and/or unwinding dsRNA produced during replication. However, no helicase helicase-like activity has ever been found to associate with any NNSV-encoded proteins, it unknown whether replication NNSVs requires participation helicase. Here,...
Enteroviruses are a large group of positive-sense single-stranded RNA viruses and include numerous human pathogens, such as enterovirus A71 (EV-A71), coxsackieviruses, echoviruses. However, no approved EV antiviral drugs available.
Genetic mutations lead to the production of mutated proteins from which peptides are presented T cells as cancer neoantigens. Evidence suggests that target neoantigens main mediators effective immunotherapies. Although algorithms have been used predict neoantigens, only a minority immunogenic. The factors influence neoantigen immunogenicity not completely understood. Here, we classified human neoantigen/neopeptide data into three categories based on their TCR-pMHC binding events. We observed...
Cancer patients undergoing chemotherapy often experience anorexia and weight loss that significantly deteriorates overall health, reduces treatment tolerance quality of life, worsens oncologic outcomes. There are currently few effective therapeutic options to mitigate these side effects. The central melanocortin system, which plays a pivotal role in regulating appetite energy homeostasis, presents logical target for treating loss. In this preclinical study, we evaluated the efficacy TCMCB07,...
Cancer patients undergoing chemotherapy often experience anorexia and weight loss that substantially deteriorates overall health, reduces treatment tolerance quality of life, worsens oncologic outcomes. There are currently few effective therapeutic options to mitigate these side effects. The central melanocortin system, which plays a pivotal role in regulating appetite energy homeostasis, presents logical target for treating loss. In this preclinical study, we evaluated the efficacy TCMCB07,...
Abstract Genetic mutations lead to the production of mutated proteins from which peptides are presented T cells as cancer neoantigens. Evidence suggests that target neoantigens main mediators effective immunotherapies. Although algorithms have been used predict neoantigens, only a minority immunogenic. The factors influence neoantigen immunogenicity not completely understood. Here, we classified human neoantigen/neopeptide data into three categories based on their TCR-pMHC binding events. We...