Hydrogen therapy is an emerging and highly promising strategy for the treatment of inflammation-related diseases. However, nonpolarity low solubility hydrogen under physiological conditions results in a limited therapeutic effect. Herein, we develop biocompatible magnesium micromotor coated with hyaluronic acid as generator precise rheumatoid arthritis management. The bubbles generated locally not only function propellant motion but also active ingredient reactive oxygen species (ROS)...

Chemodynamic therapy (CDT) is an emerging strategy for cancer treatment based on Fenton chemistry, which can convert endogenous H2O2 into toxic ·OH. However, the limited endocytosis of passive CDT nanoagents with low penetrating capability resulted in unsatisfactory anticancer efficacy. Herein, we propose successful fabrication a self-propelled biodegradable nanomotor system hollow MnO2 nanoparticles catalytic activity active Fenton-like Mn2+ delivery and enhanced CDT. Compared counterparts,...

Inducing neural stem cells to differentiate and replace degenerated functional neurons represents the most promising approach for degenerative diseases including Parkinson's disease, Alzheimer's etc. While diverse strategies have been proposed in recent years, of these are hindered due uncontrollable cell fate device invasiveness. Here, we report a minimally invasive micromotor platform with biodegradable helical Spirulina plantensis (S. platensis) as framework superparamagnetic Fe3O4...

Various strategies have been designed for myotube contraction and skeletal muscle stimulation in recent years, aiming the field of tissue engineering bionics. However, most current approaches lack controllability adaptability precise stimulation, especially at microlevel. Herein, wireless activation by using magnetic biohybrid microswimmers combination with near-infrared (NIR) laser irradiation is successfully demonstrated. Biohybrid are fabricated dip-coating superparamagnetic Fe3O4...

The purpose of the study was to reveal therapeutic effect quercetin (QUE) nanoparticle complex on diabetic nephropathy (DN) by regulating expression intercellular adhesion molecular-1 (ICAM-1) endothelium as compared free QUE. QUE 10 mg/kg a single abdominal subcutaneous injection daily for 8 weeks continuously in rats and every 5 days, administered rats. Blood left kidneys were collected; pathological change kidney, renal function, oxidative stress level, blood glucose serum lipid, urine...

Abstract Micro/nanomotors are revolutionary miniaturized robotic systems capable of converting diverse energy sources, including light, ultrasound, and thermal heat, into mechanical motion. This fascinating research area is emerging developing at a rapid pace, demonstrating potential in multiple fields. While their locomotion momentum capabilities have been explored medical treatments, microsurgery diagnosis, the aspect intrinsic energies usable forms remains unexplored. Here, we proposed...

Inspired by the tactic organisms in Nature that can self-direct their movement following environmental stimulus gradient, we proposed a DNase functionalized Janus nanoparticle (JNP) nanomotor system for first time, which be powered ultralow nM to μM levels of DNA. The exhibited interesting chemotactic behavior toward DNA richer area, is physiologically related with many diseases including tumors. In presence subtle gradient generated apoptotic tumor cells, cargo loaded nanomotors were able...

Diabetes is a metabolic disorder characterized by hyperglycemia due to defective insulin secretion or its biological dysfunction. However, frequent subcutaneous injection of often results in discomfort and local tissue infection. Herein, we demonstrate the successful fabrication mini-tablet system based on self-propelled micromotors with biocompatibility biodegradability for oral colon administration insulin. The layer first constructed onto surface magnesium micromotor via electrostatic...

<b><i>Background/Aims: </i></b>Diabetes mellitus (DM) can lead to renal damage and dysfunction, exacerbate ischemia/reperfusion injury (RI/RI). The aim of this study was investigate the protective effect GSK-3β inhibitor TDZD-8 against RI/RI through Nrf2/TrxR2 signaling pathway in a rat DM model. <b><i>Methods:</i></b> A model established by single injection streptozocin. Diabetic rats were pretreated with (1 mg/kg bw) or TDZD-8+auranofin (10...

Effective drugs that can be quickly delivered to and retained for a long time in the renal tubule are necessary acute kidney injury (AKI) treatment. In this study, gold nanoparticle-modified mesoporous silica (Au@MSN-NH2)-camouflaged (methoxyphenyl)(morpholino)phosphinodithioic acid (GYY4137) asymmetrical nanosystem decorated with L-serine (S; an AKI-targeting agent) D-Arg-dimethylTyr-Lys-Phe-NH2 (TK-SS31; reactive oxygen species (ROS)-sensitive thioketal linker/mitochondria-targeted...

Fungal infections are a significant cause of systemic in immunosuppressed patients. Studies indicate that the most prevalent fungal pathogens include Candida albicans (25 %), non-albicans species and Aspergillus %) [1]. Malassezia, lipophilic, opportunistic pathogenic yeast, primarily causes skin infections, but there increasing reports invasive infections. This report describes Suspected multisystem infection with Malassezia bone marrow transplant patient, detailing diagnosis treatment...

Abstract: Brain ischemia/reperfusion (I/R) injury (BI/RI) is a leading cause of death and disability worldwide. However, the outcome pharmacotherapy for BI/RI remains unsatisfactory. Innovative approaches enhancing drug sensitivity recovering neuronal activity in treatment are urgently needed. The purpose this study was to evaluate protective effects tumor necrosis factor (TNF)-α-loaded poly(ethylene glycol)- b -(poly(ethylenediamine l-glutamate)- g -poly(l-lysine)) (TNF-α/PEG- -(PELG-...

Renal ischemia/reperfusion (I/R) injury (RI/RI) is a common complication of diabetes, and it may be involved in altering intracellular calcium concentrations at its onset, which can result inflammation, abnormal lipid metabolism, the production reactive oxygen species (ROS), nitroso-redox imbalance. The calcium-sensing receptor (CaSR) G-protein coupled receptor, however, functional involvement CaSR diabetic RI/ RI remains unclear. present study was intended to investigate role on RI/RI...

Cancer remains a primary threat to human lives. Recently, amplification of tumor-associated reactive oxygen species (ROS) has been used as boosting strategy improve tumor therapy. Here, we report on bone-targeting prodrug mesoporous silica-based nanoreactor for combined photodynamic therapy (PDT) and enhanced chemotherapy osteosarcoma. Because surface modification biphosphate moiety the permeability retention effect, formed shows efficient accumulation in osteosarcoma exhibits long-term...

<b><i>Background/Aims:</i></b> Chelerythrine (CHE), a benzophenanthridine alkaloid, is potent, selective, and cell-permeable protein kinase C (PKC) inhibitor. The purpose of the present study was to evaluate effect CHE on myocardial recovery after renal ischemia/reperfusion (I/R)-induced injury (RI/RMI) in streptozocin (STZ)-induced diabetic rat model. <b><i>Methods:</i></b> Diabetes mellitus (DM) rats preconditioned with D, L-propargylglycine...

The aim of this study was to observe the therapeutic effect insulin-loaded linear poly(ethylene glycol)-brush-like poly(l-lysine) block copolymer glycol)-b-(poly(ethylenediamine l-glutamate)-g-poly(l-lysine)) (PEG-b-(PELG-g-PLL) on renal ischemia/reperfusion-induced lung injury through downregulating hypoxia-inducible factor (HIF) as compared free insulin. Sprague Dawley rats were pretreated with 30 U/kg insulin or insulin/PEG-b-(PELG-g-PLL) complex, and then subjected 45 minutes ischemia 24...

Background: The objective of this study was to survey the therapeutic function curcumin-encapsulated poly(gamma-benzyl l-glutamate)-poly(ethylene glycol)-poly(gammabenzyl l-glutamate) (PBLG-PEG-PBLG) (P) on diabetic cardiomyopathy (DCM) via cross regulation effect calcium-sensing receptor (CaSR) and endogenous cystathionine-γ-lyase (CSE)/hydrogen sulfide (H 2 S). Methods: Diabetic rats were preconditioned with 20 mg/kg curcumin or curcumin/P complex continuously for 8 weeks. blood...

The purpose of this study was to observe the functions preconditioning with endoplasmic reticulum stress (ERS) whether alleviated heart ischemia/reperfusion injury (HI/RI) via modulating IRE1/ATF6/RACK1/PERK and PGC-1α expressions in diabetes mellitus (DM) or not. Diabetic rats were pretreated 0.6 mg/kg tunicamycin (TM, administered intraperitoneal injection 30 minutes prior I/R procedures), then subjected 45 ischemia 3 hours reperfusion. Blood myocardial tissues collected, pathological...

The purpose of the research was to explore therapeutic action simvastatin-loaded poly(ethylene glycol)-b-poly(gamma-benzyl l-glutamate) (PEG-b-PBLG50) on intestinal ischemia/reperfusion injury (II/RI) through downregulating bone morphogenetic protein 4 (BMP4)/cyclooxygenase-2 (COX-2) pathway as compared free simvastatin (Sim). Sprague Dawley rats were preconditioned with 20 mg/kg Sim or simvastatin/PEG-b-PBLG50 (Sim/P) compounds, and then subjected 45 min ischemia 1 h reperfusion. blood...

<b><i>Background/Aims:</i></b> Ischemia/reperfusion (I/R) is the most common cause of acute renal injury. I/R-induced oxidative stress involved in development injury, which can be reversed by supplementation with L-arginine, a precursor nitric oxide (NO). This study was conducted to evaluate alterations expression transcription factors [nuclear factor kappa B (NF-κB), nuclear factor-E2-related factor-2 (Nrf2), and heme oxygenase 1 (HO-1)] heat shock protein 70 (HSP70)...

<b><i>Background/Aims: </i></b>Mast cells are sparsely distributed in the kidneys under normal conditions; however, number of mast increases dramatically during renal ischemia/reperfusion injury (RI/RI). When stimulated, numerous mediators released, and pathological conditions, they produce a wide range biological effects. The aim this study was to investigate effect intervention cell function before reperfusion on RI/RI. <b><i>Methods:...

Abstract: The poly(ethylene glycol)- b -brush poly(l-lysine) polymer (PEG- -(PELG 50 - g -PLL 3 )) was synthesized and evaluated as a nanocarrier for prolonging delivery of exenatide through the abdominal subcutaneous injection route. isoelectric point 4.86, could combine with PEG- ) polymers via electrostatic interactions at pH 7.4. This good candidate achieving prolonged drug exenatide, considering its high molecular weight. Besides physicochemical characterization polymer, in vitro vivo...

To synthesize a puerarin nanoparticle based on glycyrrhetinic acid (GA)-PEG-PBLA and evaluate it in vivo.In this study, drug was synthesized, characterized assessed as delivery system. Nanoparticle GA-PEG-PBLA could combine with via hydrophobic interaction to form the compound. Puerarin be quickly efficiently loaded at pH 7.4. Further, GA-PEG-PBLA-mediated system target for liver that had GA receptor binding. The antiliver ischemia/reperfusion injury role of puerarin/GA-PEG-PBLA measured...