A5060090085- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Neurosurgical Procedures and Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Nerve injury and regeneration
- Neurological Disease Mechanisms and Treatments
- Vagus Nerve Stimulation Research
- Neurogenesis and neuroplasticity mechanisms
- Pluripotent Stem Cells Research
- Cerebrovascular and genetic disorders
- Neurofibromatosis and Schwannoma Cases
- Bone Tumor Diagnosis and Treatments
- Moyamoya disease diagnosis and treatment
- Meningioma and schwannoma management
Zhejiang University
2021-2024
First Affiliated Hospital Zhejiang University
2020-2024
Background: Patients with poor-grade aneurysmal subarachnoid hemorrhage (aSAH), defined as World Federation of Neurosurgical Societies (WFNS) grades IV–V have high rates disability and mortality. The objective this study was to accurately prognosticate the outcomes patients aSAH by developing a new scoring model. Methods: A total 147 in our center were enrolled. Risk variables identified multivariate logistic regression analysis used devise model (total score, 0–9 points). scores estimated...
Background Spinal schwannomas (SSs) are benign tumors affecting the nerve sheath, accounting for 25% of spinal root tumors. Surgery represents mainstay treatment SS patients. Following surgery, approximately 30% patients experienced developed new or worsening neurological deterioration, which probably represented an inevitable complication sheath tumor surgery. The objective this study was to identify rates deterioration in our center and accurately predict outcomes with by developing a...
Abstract Subarachnoid hemorrhage (SAH) is a serious hemorrhagic event with high mortality and morbidity. Multiple injurious events produced by SAH can lead to series of pathophysiologic processes in the hypothalamus that severely impact patients’ life. These usually result physiologic derangements dysfunction brain multiple organs. This involved dimensions genome metabolome. In our study, we induced model rats obtain hypothalamic tissue serum. The samples were subsequently analyzed...
Background Anaemia is a severe and common complication in patients with aneurysmal subarachnoid haemorrhage (aSAH). Early intervention for at-risk before anaemia occurs indicated as potentially beneficial, but no validated method synthesises patients’ complicated clinical features into an instrument. The purpose of the current study was to develop externally validate nomogram that predicted postacute phase after aSAH. Methods We developed novel aSAH predict (3 days occurrence aSAH, prior...
Background. Hematoma expansion (HE) is a relatively common complication after intracerebral hemorrhage.Objectives.To explore the association between systemic inflammatory response syndrome (SIRS) and HE in patients with hemorrhage (ICH). Materials methods.From June 2013 to October 2020, sociodemographic data clinical of 780 ICH were collected.The logistic regression analysis odd ratios (ORs) 95% confidence intervals (95% CIs) was performed analyze risk factors for ICH.Results.Hematoma...
(1) Background: CC chemokine ligand 23 (CCL23) is a implicated in the inflammatory response following brain damage. The aim of this study to identify change serum CCL23 levels within 24 h after aSAH and whether are associated with initial clinical severity, delayed cerebral ischemia (DCI), functional outcome patients aneurysmal subarachnoid hemorrhage (aSAH). (2) Methods: 102 61 controls were included prospective observational study. All data collected prospectively, their measured. Initial...
Abstract Ischemic stroke is one of the world's leading causes death and disability. During ischemic stroke, neuronal caused by inflammation, oxidative stress, apoptosis, excitatory toxicity. For a long time, there has been lot interest in various studies to promote repair nerve damage after stroke. However, mechanisms underlying complex pathophysiological processes remain be fully elucidated. Cerebral Ras-related C3 botulinum toxin substrate (Rac) 1 was initially associated with poor...
Abstract Background Patients with poor-grade aneurysmal subarachnoid hemorrhage (aSAH), defined as World Federation of Neurosurgical Societies (WFNS) grade IV-V has high rates disability and mortality. The objective this research is to prognosticate outcomes aSAH accurately. Methods A total 147 patients in our center were enrolled. Risk variables identified by multivariate logistic regression used devise the scoring model (total score 0–9 points). values estimated according β coefficients....