A5022076487- Cannabis and Cannabinoid Research
- Regulation of Appetite and Obesity
- Adipose Tissue and Metabolism
- Sleep and Wakefulness Research
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Diet, Metabolism, and Disease
- Eating Disorders and Behaviors
- GABA and Rice Research
- Amino Acid Enzymes and Metabolism
- Dietary Effects on Health
- Biochemical Analysis and Sensing Techniques
- Neurotransmitter Receptor Influence on Behavior
- Alcohol Consumption and Health Effects
- Biochemical effects in animals
- Cholinesterase and Neurodegenerative Diseases
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Neuroscience and Neuropharmacology Research
- Enzyme Structure and Function
- Liver Disease Diagnosis and Treatment
- Biochemical and Molecular Research
- Adipokines, Inflammation, and Metabolic Diseases
- Microbial Metabolites in Food Biotechnology
- Diet and metabolism studies
Hebrew University of Jerusalem
2008-2024
Hadassah Medical Center
1997-2022
We aimed to demonstrate the involvement of 5-HT(1A) receptors in therapeutic effect cannabidiol, a non-psychoactive constituent Cannabis sativa, model hepatic encephalopathy induced by bile-duct ligation (BDL) mice.Cannabidiol (5 mg x kg(-1); i.p.) was administered over 4 weeks BDL mice. Cognition and locomotion were evaluated using eight-arm maze open field tests respectively. Hippocampi analysed RT-PCR for expression genes tumour necrosis factor-alpha receptor 1, brain-derived neurotrophic...
Although adequate nutrition is essential for optimal neural activity and survival, mild energy restriction may improve cognition prolong longevity. Energy status monitored by the cellular AMP-activated protein kinase (AMPK) system, whereas leptin regulates total balance. We investigated roles of AMPK in survival under diet (DR). Hippocampal increases with restriction. Modest activation (DR to 60%) induces neurogenesis improves cognition. However, DR 40% augmented activity, reduced...
BACKGROUND AND PURPOSE Hepatic encephalopathy is a neuropsychiatric disorder of complex pathogenesis caused by acute or chronic liver failure. We investigated the effects cannabidiol, non‐psychoactive constituent Cannabis sativa with anti‐inflammatory properties that activates 5‐hydroxytryptamine receptor 5‐HT 1A , on brain and functions in model hepatic associated fulminant failure induced mice thioacetamide. EXPERIMENTAL APPROACH Female Sabra were injected either saline thioacetamide...
Trimethylamine N-oxide (TMAO) has been associated with atherosclerosis and poor outcome. We evaluated the prognostic impact of intra-hospital TMAO variation on patient Blood samples from 149 patients acute myocardial infarction (AMI) were taken admission discharge. Plasma was determined by HPLC-MS. The endpoint a composite three-point MACE (major adverse cardiovascular events) including all-cause mortality, re-infarction or heart failure (HF) development. Median concentration significantly...
Leptin is a potent AMP kinase (AMPK) inhibitor that central to cell survival. Hence, we explored the effects of leptin on neurogenesis and angiogenesis after stroke. Neural stem cells (NSC) were grown as neurospheres in culture treated with vehicle or neurosphere size terminal differentiation then determined. We endogenous repair mechanisms vivo. Sabra mice underwent photothrombotic stroke, given newborn labeled Bromo-deoxy-Uridine. Functional outcome was studied neurological severity score...
Acute exposure to bacterial lipopolysaccharide (LPS) is a potent inducer of immune response as well hypophagia. Nevertheless, desensitization responses LPS occurs during long-term endotoxin. We induced endotoxin tolerance, injecting repeated (6LPS) doses compared with single (1LPS) treatment. 1LPS, but not 6LPS group, showed decreased food intake and body weight, which was associated an increased plasma leptin higher mRNA expression OB-Rb, MC4R, SOCS3 in the hypothalamus. Hypophagia by 1LPS...
OBJECTIVES We have shown the beneficial effects of cannabinoids in a murine model hepatic encephalopathy following thioacetamide and now report their on liver injury. METHODS Fulminant failure (FHF) was induced by administration 200 mg/kg to wild-type (WT) CB2 Knockout (KO) mice. Twenty-four hours later, mice were injected with 2-arachidonoylglycerol (CB1, CB2, TRPV1 agonist), HU308 (CB2 SR141716 A (CB1 receptor blocker), A+2-AG, SR144528 capsaicin capsazepine (TRPV1 agonist antagonist...
Brain ischemia is associated with detrimental changes in energy production and utilization. Therefore, we hypothesized that leptin, an adipokynin hormone protecting against severe depletion, would reduce infarct volume improve functional outcome after stroke. Male Sabra mice underwent permanent middle cerebral artery occlusion (PMCAO) by photothrombosis. Following initial dose-response time-window experiments animals were treated vehicle or examined daily a neurological severity score (NSS)...
Hepatic encephalopathy (HE) is a neuropsychiatric disorder of complex pathogenesis caused by acute or chronic liver failure. We studied the etiology cerebral dysfunction in murine model HE induced either bile duct ligation thioacetamide administration. report that stimulation AMP-activated protein kinase (AMPK), major intracellular energy sensor, compensatory response to This function AMPK regulated endocannabinoids. The cannabinoid system controls systemic balance via receptors CB-1 and...
Hepatic encephalopathy is a neuropsychiatric syndrome caused by liver failure. In view of the effects cannabinoids in thioacetamide-induced model hepatic and disease beneficial effect capsaicin (a TRPV1 agonist) disease, we assumed that may also affect encephalopathy.Fulminant failure was induced mice thioacetamide 24 h later, animals were injected with one following compound(s): 2-arachidonoylglycerol (CB(1), CB(2) receptor agonist); HU308 (CB(2) agonist), SR141716A (CB(1) antagonist);...
Abstract Leptin is a potent AMP kinase (AMPK) inhibitor that induces neuroprotection, neurogenesis, and angiogenesis when administered immediately after stroke. To dissociate these effects, we explored the effects of delayed administration leptin, at 10 days stroke onset, on neurogenesis Sabra mice underwent photothrombotic were treated with vehicle or leptin given either as single dose in triple dosing, later. Newborn cells labeled bromodeoxyuridine. Functional outcome was studied...
We have modified for mice the activity wheel model of Routtenberg to study effects tyrosine on exercise tolerance, behavior, and brain neurochemistry.Mice were fed 2 h.d(-1) over a 2-wk period. During second week, each group was injected daily with either saline or (100 mg.kg(-1).d(-1)) exercised running wheel. Controls in cages inactivated wheels received same treatment feeding protocols as experimental groups. Food consumption cognitive function (eight-arm maze) evaluated 1 wk. Brains then...