A5003765997- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Multiple Sclerosis Research Studies
- Alzheimer's disease research and treatments
- Architecture, Modernity, and Design
- Amyotrophic Lateral Sclerosis Research
- Autism Spectrum Disorder Research
- Neonatal and fetal brain pathology
- Stress Responses and Cortisol
- Immunotherapy and Immune Responses
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neuropharmacology Research
- Autoimmune and Inflammatory Disorders Research
- Barrier Structure and Function Studies
- Monoclonal and Polyclonal Antibodies Research
- Neuropeptides and Animal Physiology
- Systemic Lupus Erythematosus Research
- Parkinson's Disease Mechanisms and Treatments
- MicroRNA in disease regulation
- Exercise and Physiological Responses
- Autophagy in Disease and Therapy
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Mesenchymal stem cell research
- Spinal Cord Injury Research
AHEPA University Hospital
2014-2024
Aristotle University of Thessaloniki
2015-2024
Bard College
2015-2024
Max Planck Institute for the History of Science
2018
Hadassah Medical Center
2009
Activity-dependent neuroprotective protein (ADNP) differentially interacts with chromatin to regulate essential genes. Because complete ADNP deficiency is embryonic lethal, the outcome of partial was examined. ADNP(+/-) mice exhibited cognitive deficits, significant increases in phosphorylated tau, tangle-like structures, and neurodegeneration compared ADNP(+/+) mice. Increased tau hyperphosphorylation known cause memory impairments neurodegenerative diseases associated tauopathies,...
Background: A possible role of autoimmunity in Alzheimer disease pathogenesis has recently attracted increasing attention.Vaccination with amyloid- peptide was reported to cause marked reduction amyloid deposition, but it also induced encephalitis.Not much is known regarding neurofibrillary tangle-related autoimmune effects.Objective: To use the main component tanglesmicrotubule-associated tau protein-to test feasibility active induction a neuroautoimmune disorder mice.
Exposure to environmental enrichment can beneficially influence the behavior and enhance synaptic plasticity. The aim of present study was investigate mediated effects on postnatal stress-associated impact with regard behavior, stress reactivity as well plasticity changes in dorsal hippocampus. Wistar rat pups were submitted a 3 h maternal separation (MS) protocol during days 1-21, while another group left undisturbed. On day 23, subgroup from each rearing condition (maternal separation,...
Abstract Given our recent discovery of somatic mutations in autism spectrum disorder (ASD)/intellectual disability (ID) genes postmortem aged Alzheimer’s disease brains correlating with increasing tauopathy, it is important to decipher if tauopathy underlying brain imaging results atrophy ASD/ID children. We concentrated on activity-dependent neuroprotective protein (ADNP), a prevalent gene. The unique availability multiple sections 7-year-old male, heterozygous for ADNP de novo mutation...
Autophagy plays a key role in the pathophysiology of schizophrenia as manifested by 40% decrease BECN1/Beclin 1 mRNA postmortem hippocampal tissues relative to controls. This was coupled with deregulation essential ADNP (activity-dependent neuroprotector homeobox), binding partner MAP1LC3B/LC3B (microtubule-associated protein light chain 3 β) another major constituent autophagy. The drug candidate NAP (davunetide), peptide fragment from ADNP, enhanced ADNP-LC3B interaction. Parallel genetic...
Statin treatment has been associated with a reduced risk of Alzheimer disease and decreased amyloid deposition in mouse models. No animal studies have reported effects statins on tau aggregates neurofibrillary tangles (NFTs), the pathological hallmarks that correlate dementia. We investigated effect NFTs transgenic tauopathy model found following: 1) 1-month blood-brain barrier-permeable agent simvastatin normocholesterolemic aged mice significantly NFT burden lectin-positive microglia; 2)...
Abstract Activity-dependent neuroprotective protein (ADNP), essential for brain formation, was discovered as a leading de novo mutated gene causing the autism-like ADNP syndrome. This syndrome is phenotypically characterized by global developmental delays, intellectual disabilities, speech impediments, and motor dysfunctions. The Adnp haploinsufficient mouse mimics human in terms of synapse density expression patterns, well developmental, motor, cognitive abilities. Peripheral also biomarker...
Inhibition of the myelin-associated neurite outgrowth inhibitor Nogo-A has been found to be beneficial in experimental autoimmune encephalomyelitis (EAE), but there are little data on its expression dynamics during disease course. We analyzed mRNA and protein course EAE 27 C57BL/6 mice 8 controls. Histopathologic molecular analyses were performed Day 0 (naive), preclinical (Day 10), acute (Days 18–22) chronic 50) time points. In situ hybridization real-time polymerase chain reaction revealed...
Background : Exercise training induces beneficial effects on neurodegenerative diseases, and specifically multiple sclerosis (MS) it’s model experimental autoimmune encephalomyelitis (EAE). However, it is unclear whether exercise exerts direct protective the central nervous system (CNS), nor are mechanisms of neuroprotection fully understood. In this study, we investigated neuroprotective high-intensity continuous (HICT) against development neuroinflammation role resident microglia. Methods...
Nogo-A and its putative receptor NgR are considered to be among the inhibitors of axonal regeneration in CNS. However, few studies so far have addressed issue local complex multilateral localization within inflammation an MS mouse model autoimmune demyelination.Chronic experimental encephalomyelitis (EAE) was induced C57BL/6 mice. Analyses were performed on acute (days 18-22) chronic (day 50) time points compared controls. The temporal spatial expression Nogo (NgR coreceptors) studied at...
Nerve growth factor (NGF) and its receptors, tropomyosin receptor kinase A (TrkA) pan-neurotrophin p75 (p75NTR), are known to play bidirectional roles between the immune nervous system. There only few studies with inconclusive results concerning expression pattern role of NGF, TrkA, p75NTR (NGF system) under neuroinflammatory conditions in multiple sclerosis (MS) mouse model, experimental autoimmune encephalomyelitis (EAE). The aim this study is investigate temporal different cell types NGF...
Abstract Background Exercise training (ET) has beneficial effects on multiple sclerosis and its animal model experimental autoimmune encephalomyelitis (EAE). However, the intensity‐dependent of ET systemic immune system in EAE remain undefined. Objective (1) To compare modulatory moderate versus high‐intensity protocols protecting against development EAE; (2) investigate whether affects autoimmunity selectively, or causes general immunosuppression. Methods Healthy mice performed treadmill...