A5076248582- Autopsy Techniques and Outcomes
- Forensic Toxicology and Drug Analysis
- COVID-19 Clinical Research Studies
- Cannabis and Cannabinoid Research
- SARS-CoV-2 and COVID-19 Research
- Vitamin D Research Studies
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Effects of Exercise
- Medical Malpractice and Liability Issues
- Healthcare cost, quality, practices
- Poisoning and overdose treatments
- Opioid Use Disorder Treatment
- Restraint-Related Deaths
- Forensic Entomology and Diptera Studies
- Cardiac Arrest and Resuscitation
- Alzheimer's disease research and treatments
- Disaster Response and Management
- COVID-19 and healthcare impacts
- Forensic Anthropology and Bioarchaeology Studies
- Paleopathology and ancient diseases
- Neuroscience of respiration and sleep
- Long-Term Effects of COVID-19
- Healthcare Quality and Management
- MicroRNA in disease regulation
- COVID-19 diagnosis using AI
University of Trieste
2020-2025
Azienda Sanitaria Universitaria Integrata di Trieste
2023-2024
Ospedale di Cattinara
2024
Ospedale Maggiore
2024
Federico II University Hospital
2024
Ospedale A. Perrino
2024
University of the Sacred Heart
2024
University of The Sacred Heart
2024
The University of Texas Health Science Center at Houston
2023
Creative Research Enterprises (United States)
2020-2023
The COVID-19 (Coronavirus Disease-19) is the most urgent health emergency worldwide and all professionals are called to give support in diagnosis treatment of patients affected by this disease. Scientific Society Hospital Legal Medicine National Health System (COMLAS) Italian Anatomical Pathology Cytology (SIAPEC) produced document with intent offering a technical professional involved autoptic activities during Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) epidemic infection.
Increased levels of circulating complement activation products have been reported in COVID-19 patients, but only limited information is available on involvement at the tissue level. The mechanisms and pathways local remain unclear. aim this study was to investigate deposition components lungs, kidneys, liver patients with determine pathway/s activation. We performed immunofluorescence analyses autopsy specimens kidney, from 12 who died acute respiratory failure. Snap-frozen samples embedded...
This study involves the histological analysis of samples taken during autopsies in cases COVID-19 related death to evaluate inflammatory cytokine response and tissue localization virus various organs. In all selected cases, SARS-CoV-2 RT-PCR on swabs collected from upper (nasopharynx oropharynx) and/or lower respiratory (trachea primary bronchi) tracts were positive. Tissue was detected using antibodies against nucleoprotein spike protein. Overall, we tested hypothesis that overexpression...
Abstract Background: To investigate the cardiotoxic role of reactive oxygen species (ROS) and products derived from catecholamines auto‐oxidation, we studied: (1) response antioxidant cardiac cellular defence systems to oxidative stress induced by norepinephrine (NE) administration, (2) effect NE administration on β 1 ‐adrenergic receptors means receptor binding assay, (3) morphological alterations related biologically cross‐talk between cytokines [tumor necrosis factor‐alpha (TNF‐α),...
(1) Background: The current outbreak of COVID-19 infection is an ongoing challenge and a major threat to public health that requires surveillance, prompt diagnosis, as well research efforts understand the viral pathogenesis. Despite this, date, very few studies have been performed concerning autoptic specimens. Therefore, this study aimed: (i) reiterate importance examination, only method able precisely define cause death; (ii) provide complete post-mortem histological immunohistochemical...
SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) is a responsible for COVID-19 (coronavirus disease 2019) which resulted in cluster of cases pneumonia that originated China around 31 December 2019 and has subsequently spread across the globe. Currently, represents health emergency worldwide, leading, severe cases, to pneumonia, syndrome, multiorgan dysfunction or failure, death. In context limited scientific knowledge evidence infection, guidance becoming increasingly necessary...
Trimethylamine N-oxide (TMAO) has been associated with atherosclerosis and poor outcome. We evaluated the prognostic impact of intra-hospital TMAO variation on patient Blood samples from 149 patients acute myocardial infarction (AMI) were taken admission discharge. Plasma was determined by HPLC-MS. The endpoint a composite three-point MACE (major adverse cardiovascular events) including all-cause mortality, re-infarction or heart failure (HF) development. Median concentration significantly...
In the context of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, significant attention was given to pulmonary manifestations. However, cardiac involvement is increasingly recognized as a critical factor influencing prognosis, leading myocardial damage, heart failure, coronary syndromes, potentially lethal arrhythmic events, and sudden death. Despite these findings, there lack studies detailing necroscopic, macroscopic, microscopic changes associated with SARS-CoV-2....
Background Amyloid β1‐40 (Aβ1‐40) contributes to atherosclerosis, being involved in plaque formation and destabilization. The prognostic role of Aβ1‐40 patients with acute myocardial infarction is currently limited non–ST‐segment–elevation (NSTEMI). We examined the value a real‐world cohort (both ST‐segment–elevation [STEMI] NSTEMI) identified predictors for its elevated levels. Methods Results Our population included 1119 consecutive (mean age, 67 years; 72% men; STEMI, 68%). median...
Increased levels of circulating complement activation products have been reported in COVID-19 patients, but only limited information is available on involvement at tissue level. The mechanisms and pathways local remain unclear. We performed immunofluorescence analyses autopsy specimens lungs, kidney liver from nine patients who died acute respiratory failure. Snap-frozen samples embedded OCT were stained with antibodies against components products, IgG spike protein SARS-CoV-2. Lung deposits...