A5056120002- Prostate Cancer Treatment and Research
- Sulfur Compounds in Biology
- Colorectal Cancer Treatments and Studies
- Radiopharmaceutical Chemistry and Applications
- Eicosanoids and Hypertension Pharmacology
- Gastric Cancer Management and Outcomes
- Bone health and treatments
- Cannabis and Cannabinoid Research
- Prostate Cancer Diagnosis and Treatment
- Drug-Induced Hepatotoxicity and Protection
- Forensic Toxicology and Drug Analysis
- Hormonal and reproductive studies
- Cancer Treatment and Pharmacology
- Biochemical effects in animals
- Neuroscience and Neuropharmacology Research
- Synthesis and Biological Evaluation
- Amino Acid Enzymes and Metabolism
- Colorectal and Anal Carcinomas
- Traumatic Brain Injury and Neurovascular Disturbances
- Mast cells and histamine
- Inflammatory mediators and NSAID effects
- Metastasis and carcinoma case studies
- Heme Oxygenase-1 and Carbon Monoxide
- Polyamine Metabolism and Applications
- Neutropenia and Cancer Infections
University of Siena
2010-2021
Ospedale Santa Maria alle Scotte
2020-2021
Brain Physiology Lab
2014-2015
Prostate Cancer UK
2014
Food and Drug Administration
2014
Creative Commons
2014
Policlinico Umberto I
2014
Christie's
2014
Istituto di Fisiologia Clinica
2002-2003
Istituto di Farmacologia Traslazionale
1992
Abstract Background: To investigate the cardiotoxic role of reactive oxygen species (ROS) and products derived from catecholamines auto‐oxidation, we studied: (1) response antioxidant cardiac cellular defence systems to oxidative stress induced by norepinephrine (NE) administration, (2) effect NE administration on β 1 ‐adrenergic receptors means receptor binding assay, (3) morphological alterations related biologically cross‐talk between cytokines [tumor necrosis factor‐alpha (TNF‐α),...
In this study, we investigated the effects of exposition to IC50 dose for 24 h a new synthetic cannabinoid (CB83) and phytocannabinoids Δ9-tetrahydrocannabinol (THC) cannabidiol (CBD) on HT-29 colorectal carcinoma cells. Cell viability proliferative activity evaluated using MTT, lactate dehydrogenase (LDH), CyQUANT assays showed that cell was significantly affected when CB83, THC, CBD were administered The results obtained reduced glutathione/oxidized glutathione ratio in cells exposed...
Abstract Background Diets and Omega‐3 polyunsaturated fatty acids have been considered as important factors to reduce the risk of cardiovascular inflammatory diseases, but there are few details on effects healthy subjects. The aim present study was examine variation several physiological parameters in subjects different diets supplemented with acids. Materials methods experiment carried out 33 divided into four groups according a double‐blind cross‐over design 1 : ratio for (vs. placebo)...
The effect of field foliar Fe and Zn biofortification on concentration potential bioavailability health-promoting compounds was studied in wholemeal flour two common wheat varieties (old vs modern). Moreover, the milling bread making studied. Biofortification increased (+78%) its (+48%) old variety, whereas it ineffective increasing both varieties. However, variety showed higher (+41%) (+26%) than modern one. As regard milling, had Fe, compared to white flour. Bread slightly change but...
Abstract 3,4‐Methylenedioxymethamphetamine (MDMA)‐induced neurotoxicity leads to the formation of quinone metabolities and hydroxyl radicals then production reactive oxygen species (ROS). We evaluated effect a single dose MDMA (20 mg/kg, i.p.) on enzymatic nonenzymatic cellular antioxidant defense system in different areas rat brain early hours (<6 hr) administration itself, we identified morphological expressions induced by vulnerable first 24 hr. The acute produces decrease reduced...
The aim of this study is to analyse cardiac specimens from human cocaine-related overdose, verify the hypothesis that toxicity by acute exposure high dosage cocaine could be mediated unbalanced myocardial oxidative stress, and evaluate apoptotic response. To address these issues, biochemical immunohistological markers oxidative/nitrosative stress were evaluated. We found i-NOS, NOX2 nitrotyrosine expression significantly higher in hearts subjects who had died doses cocaine, compared control...
Resistin is an adipokine involved in inflammation and able to induce the expression of other proinflammatory cytokines. It known that, human semen, resistin correlated with inflammatory cytokines sperm quality. The aim this prospective study was explore potential relationship between resistin, lipid peroxidation (LPO), catalase (CAT) activity, reduced oxidized glutathione (GSH/GSSG) ratio semen samples infertile patients leukocytospermia (no. 19), varicocele 17), fertile men 17). Semen...
Polyunsaturated fatty acid (PUFA) metabolism and tissue distribution is modulated by the oxidation of these molecules. This research aimed to investigate implication dietary n-3 PUFA supplementation (precursor long-chain PUFA) on profile oxidative status liver, testis, brain adult rabbit bucks. Twenty New Zealand White bucks were divided into four experimental groups (n = 5 per group) fed different diets for 110 days: control (CNT), standard diet containing 50 mg/kg alpha-tocopheryl acetate...