A5087175435- Bone and Dental Protein Studies
- Cancer Research and Treatments
- Prostate Cancer Treatment and Research
- Testicular diseases and treatments
- Genetic factors in colorectal cancer
- HER2/EGFR in Cancer Research
- Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Lymphoma Diagnosis and Treatment
- Cancer Cells and Metastasis
- Cutaneous lymphoproliferative disorders research
- Radiopharmaceutical Chemistry and Applications
- Cancer Immunotherapy and Biomarkers
- Cancer, Stress, Anesthesia, and Immune Response
- COVID-19 and healthcare impacts
- Radiomics and Machine Learning in Medical Imaging
- Cervical Cancer and HPV Research
- Prostate Cancer Diagnosis and Treatment
- Sexual Differentiation and Disorders
- Gestational Trophoblastic Disease Studies
- Cancer-related Molecular Pathways
- Ovarian cancer diagnosis and treatment
- Colorectal Cancer Treatments and Studies
- Fungal Infections and Studies
- Lung Cancer Treatments and Mutations
Ospedale di Circolo di Busto Arsizio
2013-2024
Swiss Center for Electronics and Microtechnology (Switzerland)
2024
University of Turin
2023
Lombardia Informatica (Italy)
2021
University of Milan
2016
European Institute of Oncology
2016
Presidio Ospedaliero
2015
Azienda Ospedaliera Sant’Antonio Abate di Gallarate
1993-2011
Ospedale Sant Antonio
1997
University of Pavia
1993
Abstract Objectives We performed data collection concerning the coronavirus disease 2019 (COVID-19) pandemic-related delay in diagnosis of cancers to individuate proper corrective procedures. Methods A comparison was made among number first pathologic diagnoses malignancy from weeks 11 20 2018, 2019, and 2020 at seven anatomic pathology units serving secondary care hospitals northern-central Italy. Results Cancer fell by 44.9% compared with average recorded 2018 2019. Melanoma nonmelanoma...
The COVID-19 (Coronavirus Disease-19) is the most urgent health emergency worldwide and all professionals are called to give support in diagnosis treatment of patients affected by this disease. Scientific Society Hospital Legal Medicine National Health System (COMLAS) Italian Anatomical Pathology Cytology (SIAPEC) produced document with intent offering a technical professional involved autoptic activities during Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) epidemic infection.
Aim: Castration-resistant prostate cancer (CRPC) eventually becomes resistant to androgen receptor pathway inhibitors like enzalutamide. Immunotherapy also fails in CRPC. We propose a new approach simultaneously revert enzalutamide resistance and rewire anti-tumor immunity. Methods: investigated vitro subcutaneous spontaneous mouse models the effects of combining GSK-126, drug inhibiting epigenetic modulator EZH2. Results: Enzalutamide GSK-126 synergized reduce CRPC growth, restraining tumor...
Among 843 cases of breast cancer, p53 oncoprotein was detected by the monoclonal antibody (MoAb) Pab-1801 in only 13%. Low-grade carcinomas (tubular, mucinous, papillary, and invasive cribriform types) did not express protein, but it observed 4.2% infiltrating lobular (6 140 cases) 50% pure medullary (5 10 cases). In intermediate-grade neoplasms, no correlation seen between status other putative determinants a poor prognosis. The latter included high tumor stage, lymph nodal involvement,...
Neurons in the adult mammalian central nervous system do not proliferate or renew themselves and consequently strong interest cell replacement therapies to repair brain spinal cord damages has emerged last decade.An injectable resorbable hydrogel with a controlled nanostructure, specifically designed for neural housing, was developed together new protocol building three-dimensional (3D) biohybrid cell/hydrogel constructs: cells are housed within polymeric matrix which is directly built...
Intervertebral disc (IVD) degeneration is inadequately understood due to the lack of in vitro systems that fully mimic mechanical and biological complexity this organ. We have recently made an advancement by developing a bioreactor able simulate physiological, multiaxial IVD loading maintain environment ex vivo models [1]. To validate new system, we simulated natural spine movement 12 bovine IVDs under combination static compression (0.1 MPa), cyclic flexion/extension (±3˚, ±6˚ or 0-6˚)...
Neuroendocrine prostate cancer (NEPC) is an aggressive form of that emerges as tumors become resistant to hormone therapies or, rarely, arises de novo in treatment-naïve patients. The urgent need for effective against NEPC hampered by the limited knowledge biology governing this lethal disease. Based on our prior observations transgenic adenocarcinoma mouse (TRAMP) spontaneous model, which genetic depletion either mast cells (MC) or matricellular protein osteopontin (OPN) increases...
Pagetoid reticulosis (PR) is a low‐grade primary cutaneous T‐cell lymphoma showing localized patches or plaques with an intrapeidermal proliferation of neoplastic T‐cells heterogeneous immunophenotype. We describe 73‐year‐old woman 8‐year history gluteal lesions PR , whom large blast cells were CD4 / CD8 double negative activated cytotoxic profile. The case was investigated using broad panel monoclonal antibodies including TCRγM1 new available antibody that recognizes the γ chain subunit...
To determine the immunohistochemical expression of epidermal growth factor receptor (EGF-R) in high grade, intermediate, and low grade tumours.Specimens from 931 breast carcinomas were partly formalin fixed paraffin wax embedded, to classify cases, frozen liquid nitrogen, cryostat sectioned, immunostained using two monoclonal antibodies clone 455 528 demonstrate EGF-R positive cells. An avidin-biotin complex peroxidase method was used after incubation with biotinylated anti-mouse antibody;...
Prostate cancer is the second leading cause of cancer-related death. The androgen deprivation therapy standard treatment for advanced stages. Unfortunately, virtually all tumors become resistant to withdrawal. progression castration-resistance not fully understood, although a recent paper has suggested translationally controlled tumor protein be implicated in process. present study was designed investigate role this prostate cancer, focusing on correlation between its expression level with...
Adenocarcinoma (ADC) is the most common histologic type of lung cancer, including in situ (lepidic), minimally invasive, and invasive forms. While former 2 types are associated with a favorable outcome, latter includes tumors variable behavior, often tumor stage–related. A recent study proposed strict morphologic criteria defining new subgroup resected stage I ADC (16% cases) outcomes (100% disease-specific survival), named “ADC low malignant potential (LMP-ADC).” The following were met: ≤3...
A 77-year-old man presented with an enlarging, 2.5 × 1.5 cm, well-defined, hard, scalp nodule mimicking a nodular basal-cell carcinoma. No other similar lesions were detected on the skin. Surgical excision was performed. Histopathological examination revealed well-demarcated dermal-hypodermal (figure 1A), composed of spindle cells showing elongated nuclei blunt ends 1B). The mitotic index 3/10HPF. Spindle smooth-muscle actin 1C) and desmin positive [...]
We describe the FDG PET/CT findings in an exceedingly rare case of metastatic pilomatrix carcinoma (PC). A 76-year-old man, who underwent incisional biopsy a soft-tissue mass frontal scalp that revealed PC, was referred for 18F-FDG scan staging purposes. showed areas increased radiotracer uptake corresponding to and unsuspected lung lesions, which were later confirmed as metastases from PC at histological analysis. Clinical condition deteriorated rapidly, patient died 3 months after initial...
Translationally controlled tumor protein is a multifaceted involved in several physiological and biological functions. Its expression normal kidney renal carcinomas, once corroborated by functional data, may add elements to elucidate physiology carcinogenesis. In this study, translationally was evaluated quantitative real time polymerase chain reaction western blotting, its localization examined immunohistochemistry on 84 nephrectomies for cancer. found the cytoplasm of proximal distal...
The present study reports the immunohistochemical reactivity of monoclonal antibody b-12 (MAb b-12) with malignant human tissues. 173 neoplastic tissues were tested: MAb stained all breast carcinomas independently their histology, different patterns within various type cancer. Some other (stomach, bowel, ovary, lung, endometrium), also reactive even if fraction positive cells was lower. A comparison between histological localization MCA and that CEA performed; anti-CEA antibodies cancer...
Whole Slide Imaging (WSI) is the most current approach to digitization of histological information. WSI developed only recently, mostly for research and teaching applications. However, one acknowledged potential use routine acquisition in diagnostic pathology labs. The present paper aims at evaluating throughput reliability scanning, by means a trial carried out acquiring 1200 slides from each 6 different Pathology laboratories, with three commercial slide scanners. Diagnostic has been also...
Abstract Castration resistant prostate cancer (CRPC) is a fatal disease. Androgen receptor pathway inhibitors, like enzalutamide, are initially effective but resistance eventually occurs, often associated to the emergence of aggressive neuroendocrine variants (NEPC). Even immunotherapy induced limited results in cancer, governed by an immunosuppressive microenvironment. Therefore, therapies needed. We here investigate preclinical models new approach aimed revert castration and simultaneously...