A5012769957- Mast cells and histamine
- Cancer Research and Treatments
- Bone and Dental Protein Studies
- Immune cells in cancer
- Immune Cell Function and Interaction
- Asthma and respiratory diseases
- Prostate Cancer Treatment and Research
- T-cell and B-cell Immunology
- Urticaria and Related Conditions
- Click Chemistry and Applications
- Immunotherapy and Immune Responses
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Food Allergy and Anaphylaxis Research
- Cancer Immunotherapy and Biomarkers
- Autoimmune Bullous Skin Diseases
- Eosinophilic Esophagitis
- Chemokine receptors and signaling
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Receptor Mechanisms and Signaling
- DNA Repair Mechanisms
- Celiac Disease Research and Management
- Immunodeficiency and Autoimmune Disorders
- Redox biology and oxidative stress
- Cancer, Stress, Anesthesia, and Immune Response
- Monoclonal and Polyclonal Antibodies Research
University of Udine
2015-2025
Medical Technologies (Czechia)
2008
Zero to Three
2003
Mast cells (MCs) are currently recognized as effector in many settings of the immune response, including host defense, regulation, allergy, chronic inflammation, and autoimmune diseases. MC pleiotropic functions reflect their ability to secrete a wide spectrum preformed or newly synthesized biologically active products with pro-inflammatory, anti-inflammatory and/or immunosuppressive properties, response multiple signals. Moreover, modulation phenotypes relies on interaction variety membrane...
To cite this article: Bossi F, Frossi B, Radillo O, Cugno M, Tedeschi A, Riboldi P, Asero R, Tedesco Pucillo C. Mast cells are critically involved in serum-mediated vascular leakage chronic urticaria beyond high-affinity IgE receptor stimulation. Allergy 2011; 66: 1538–1545. Background: Chronic (CU) is one of the most common skin disorders whose pathogenic mechanisms not fully clarified. Autoimmune aetiology can be ascribed to 45% patients with CU, and basophil histamine release positive 40%...
Abstract Inflammation plays crucial roles at different stages of tumor development and may lead to the failure immune surveillance immunotherapy. Myeloid-derived suppressor cells (MDSC) are one major components immune-suppressive network that favors growth, their interaction with mast is emerging as critical for outcome tumor-associated response. Herein, we showed occurrence cell-to-cell interactions between MDSCs in mucosa patients colon carcinoma spleen tumor-bearing mice. Furthermore,...
Abstract Mast cells have the ability to react multiple stimuli, implicating these in many immune responses. Specific signals from microenvironment which mast reside can activate different molecular events that govern distinct We previously demonstrated hydrogen peroxide (H2O2) promotes IL-4 and IL-6 mRNA production potentates FcεRI-induced cytokine release rat basophilic leukemia RBL-2H3 cells. To further evaluate effect of an oxidative (which is physiologically present inflammatory site) on...
Abstract The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor whose activity modulated by xenobiotics as well physiological ligands. These compounds may modulate inflammatory responses and contribute to the rising prevalence of allergic diseases observed in industrialized countries. Mast cells (MCs), located within tissues at boundary external environment, represent potential target AhR In this study, we report that murine human MCs constitutively express AhR, its...
Abstract Immunotherapy, including the use of checkpoint inhibitors, is a potent therapeutic approach for some cancers, but has limited success with prostate tumors, in which immune suppression instigated by tumor. The immunosuppressive capacity mast cells, promote adenocarcinoma development prostate, prompted our investigation on whether cells tolerance to SV40 Large-T antigen, transforming oncogene transgenic mouse (TRAMP) mice. incidence was reduced offspring cross between TRAMP mice and...
Abstract Multiple sclerosis is a debilitating autoimmune disease, characterized by chronic inflammation of the central nervous system. While significance gut microbiome on multiple pathogenesis established, underlining mechanisms are unknown. We found that serum levels microbial postbiotic tryptophan metabolite indole-3-carboxaldehyde (3-IAld) inversely correlated with disease duration in patients. Much like host-derived derivative l -Kynurenine, 3-IAld would bind and activate Aryl...
This study investigated the interaction between apple juice (AJ) and acarbose (A) in modulating glycemic responses, with aim of validating vivo results previously observed vitro. When administered...
Abstract Mast cells are exposed to an oxidative environment in the course of allergic and inflammatory reactions. We have examined effects H 2 O stimulation a primary rat basophilic leukemia cell line (RBL‐2H3) compared with IgE‐dependent stimulation. Like IgE stimulation, up‐regulates IL‐4 IL‐6 gene expression cytokine secretion, shows little effect on IL‐5 but does not induce IL‐10 expression. Simultaneous treatment FcϵRI triggering mast has additive In addition, we show that both stimuli...
Abstract Reactive oxygen species (ROS) are generated as by‐products of respiration and used signal transducing intermediates in out–in signaling pathways. ROS also during inflammatory responses it has been shown that hydrogen peroxide may trigger activation B‐lymphocytes, similar to cross‐linking surface immunoglobulins. On the other hand, both exogenous endogenous a major source nuclear mitochondrial DNA (mtDNA) damage. The base excision repair (BER) enzyme APE/Ref‐1 normally repairs small...
Mast cells (MCs) are tissue-resident, long lived innate immune with important effector and immunomodulatory functions. They equipped an eclectic variety of receptors that enable them to sense multiple stimuli generate specific responses according on the type, strength duration stimulation. Several studies demonstrated myeloid can retain immunological memory their encounters – a process termed ‘trained immunity’ or ‘innate memory’. As MCs among one first come into contact external...