A5062521284- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Mast cells and histamine
- Asthma and respiratory diseases
- Immune Response and Inflammation
- Allergic Rhinitis and Sensitization
- Sinusitis and nasal conditions
- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- Cancer Research and Treatments
- Epigenetics and DNA Methylation
- Vaccine Coverage and Hesitancy
- IL-33, ST2, and ILC Pathways
- RNA modifications and cancer
- Diabetes and associated disorders
- COVID-19 Impact on Reproduction
- Cancer-related gene regulation
- Ovarian cancer diagnosis and treatment
- Renal and related cancers
- Cancer Cells and Metastasis
- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Eosinophilic Esophagitis
University of Udine
2014-2025
Mast cells (MCs) are tissue-resident, long lived innate immune with important effector and immunomodulatory functions. They equipped an eclectic variety of receptors that enable them to sense multiple stimuli generate specific responses according on the type, strength duration stimulation. Several studies demonstrated myeloid can retain immunological memory their encounters – a process termed ‘trained immunity’ or ‘innate memory’. As MCs among one first come into contact external...
Among the family of regulatory B cells, subset able to produce interleukin-10 (IL-10) is most studied, yet its biology still a matter investigation. The DNA methylation profiling il-10 gene locus revealed novel epigenetic signature characterizing murine cells ready respond through IL-10 synthesis: demethylated region located 4.5 kb from transcription starting site (TSS), that we named early IL10 (eIL10rr). This feature allows distinguish are immediately prone and developmentally committed...
B lymphocytes are among the cell types whose effector functions modulated by mast cells (MCs). The B/MC crosstalk emerged in several pathological settings, notably colon of inflammatory bowel disease (IBD) patients is a privileged site which MCs and IgA+ physically interact. Herein, inducing conditional depletion red MC basophil (RMB) mice, we show that control distribution gut IgA serum levels. Moreover, dextran sulfate sodium (DSS)-treated RMB presence fundamental for enlargement...
One of the most fascinating aspects immune system is its dynamism, meant as ability to change and readapt according organism needs. Following an insult, we assist spontaneous organization different cells which cooperate, locally at distance, build up appropriate response. Throughout tumor progression, adaptations within systemic environment, or macroenvironment, result in promotion growth, invasion metastasis distal organs, but also dramatic changes activity composition system. In this work,...
<h3>Introduction/Background</h3> Emerging evidence underscore the critical involvement of B cells in ovarian cancer pathogenesis. infiltrating tumor microenvironment (TME) display both pro- and anti- tumorigenic activities. However, currently, there is no validated panel for analyzing tumor-infiltrating by cytofluorimetry. We developed a high dimensional approach wide characterization immune infiltrate optimized specific immunophenotyping cell subpopulations peripheral blood TME. The...