- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Neonatal Respiratory Health Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Pediatric health and respiratory diseases
- Gastrointestinal motility and disorders
- IL-33, ST2, and ILC Pathways
University of Perugia
2019-2024
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2019
Istituti di Ricovero e Cura a Carattere Scientifico
2019
Vita-Salute San Raffaele University
2019
Abstract Multiple sclerosis is a debilitating autoimmune disease, characterized by chronic inflammation of the central nervous system. While significance gut microbiome on multiple pathogenesis established, underlining mechanisms are unknown. We found that serum levels microbial postbiotic tryptophan metabolite indole-3-carboxaldehyde (3-IAld) inversely correlated with disease duration in patients. Much like host-derived derivative l -Kynurenine, 3-IAld would bind and activate Aryl...
OPINION article Front. Immunol., 28 February 2019Sec. Microbial Immunology Volume 10 - 2019 | https://doi.org/10.3389/fimmu.2019.00323