A5016120516- Bone Tissue Engineering Materials
- Hydrogels: synthesis, properties, applications
- Nerve injury and regeneration
- biodegradable polymer synthesis and properties
- 3D Printing in Biomedical Research
- Dental Implant Techniques and Outcomes
- Electrospun Nanofibers in Biomedical Applications
- Graphene and Nanomaterials Applications
- Spinal Cord Injury Research
- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Tissue Engineering and Regenerative Medicine
- Orthopaedic implants and arthroplasty
- Drug Solubulity and Delivery Systems
- RNA Interference and Gene Delivery
- Periodontal Regeneration and Treatments
- Mesenchymal stem cell research
- Bone fractures and treatments
- Advanced Polymer Synthesis and Characterization
- Advanced Sensor and Energy Harvesting Materials
- Total Knee Arthroplasty Outcomes
- Bone and Dental Protein Studies
- Neuroscience and Neural Engineering
- Supramolecular Self-Assembly in Materials
- Polymer Surface Interaction Studies
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology
2019-2024
Università della Svizzera italiana
2020-2024
Vir Biotechnology (Switzerland)
2012-2024
University of Applied Sciences and Arts of Southern Switzerland
2013-2023
Mario Negri Institute for Pharmacological Research
2011-2019
Ospedale Policlinico San Martino
2018-2019
ETH Zurich
2018
Politecnico di Milano
2005-2014
Swiss Institute for Regenerative Medicine
2013-2014
Weatherford College
2013
Coastal countries have traditionally relied on the existing marine resources (e.g., fishing, food, transport, recreation, and tourism) as well tried to support new economic endeavors (ocean energy, desalination for water supply, seabed mining). Modern societies lifestyle resulted in an increased demand dietary diversity, better health well-being, biomedicines, natural cosmeceuticals, environmental conservation, sustainable energy sources. These societal needs stimulated interest of...
Bone healing is an impressive ability of the human body, but critical-sized bone defects require external intervention. Bioceramic scaffolds with excellent biocompatibility and bioactivity have been developed to treat non-healing because their unique features for repair. Meanwhile, mechanical properties material continue be disadvantageous. This review focuses on (i) essential factors in affecting improving bioceramic-based scaffolds' properties, including porosity, pore size, methods,...
Much evidence shows that acute and chronic inflammation in spinal cord injury (SCI), characterized by immune cell infiltration release of inflammatory mediators, is implicated development the secondary phase occurs after trauma worsening damage. Activation microglia/macrophages associated response appears to be a self-propelling mechanism leads progressive neurodegeneration persisting pain state. Recent advances polymer science have provided huge amount innovations leading increased interest...
The design of nanostructures carrying therapeutic molecules represents the new frontier in biological and medical fields. In particular, researchers have identified nanogels as promising tools response to critical issues intracellular delivery: because their peculiar properties, including swelling behavior, are able cross cellular membrane (clathrin-mediated endocytosis, caveolin-mediated phagocytosis, macropinocytosis) release cargo cytosol, avoiding activation immune responses. However,...
The diffusion and aggregation of sodium fluorescein in aqueous solutions was investigated adopting density functional theory (DFT) molecular dynamics (MD) simulations. First, DFT calculations implicit water were used to determine minimum energy structure atomic charges the solute, which then as input for explicit MD self-diffusion coefficient calculated using Einstein equation, computing mean square displacement from 24 ns trajectories. coefficient, 0.42 · 10–5 cm2 s–1, is good agreement...
Hydrogels are commonly studied for tissue engineering applications and controlled drug delivery. In order to evaluate their reliability as scaffolds delivery devices, literature describes many release studies performed involving different analytical techniques. However, these experiments can be expensive, time-consuming, often not reproducible. this study, two injectable agar-carbomer-based hydrogels were studied, both being loaded with sodium fluorescein, a harmless fluorophore steric...
The present work is focused on the development and validation of a mechanistic model describing degradation drug-loaded polylactic-co-glycolic acid microparticles drug release process from such devices. Microparticles' described through mass conservation equations; application population balances allows detailed description hydrolysis kinetics, which also takes into account autocatalytic behavior that characterizes bulk eroding polymers. Drug considers both dissolution diffusion dissolved...
The use of polymers and nanomaterials has vastly grown for industrial biomedical sectors during last years. Before any designation or selection their nanocomposites, it is vital to recognize the targeted applications which require these platforms be modified. Surface functionalization introduce desired type quantity reactive functional groups target a cell tissue in human body pivotal approach improve physicochemical biological properties materials. Herein, advances functionalized polymer...
Safe-by-Design (SbD) concepts foresee the risk identification and reduction as well uncertainties regarding human health environmental safety in early stages of product development. The EU's NANoREG project further on H2020 ProSafe initiative, NanoReg2, CALIBRATE projects have developed a general SbD approach for nanotechnologies (e.g., paints, textiles, etc.). Based it, GoNanoBioMat elaborated methodological (GoNanoBioMat approach) nanomedicines with focus polymeric nanobiomaterials (NBMs)...