A5045591592- Spinal Cord Injury Research
- Nerve injury and regeneration
- Neuroinflammation and Neurodegeneration Mechanisms
- Nanoparticle-Based Drug Delivery
- Mesenchymal stem cell research
- 3D Printing in Biomedical Research
- Graphene and Nanomaterials Applications
- Advanced Drug Delivery Systems
- RNA Interference and Gene Delivery
- Hydrogels: synthesis, properties, applications
- Immune cells in cancer
- Neurogenesis and neuroplasticity mechanisms
- Electrospun Nanofibers in Biomedical Applications
- Thermal Regulation in Medicine
- Pressure Ulcer Prevention and Management
- Adenosine and Purinergic Signaling
- Amyotrophic Lateral Sclerosis Research
- Cerebral Palsy and Movement Disorders
- Veterinary Pharmacology and Anesthesia
- Neurogenetic and Muscular Disorders Research
- Parkinson's Disease Mechanisms and Treatments
- Wound Healing and Treatments
- Proteoglycans and glycosaminoglycans research
- Biochemical Acid Research Studies
- Diagnosis and Treatment of Venous Diseases
Mario Negri Institute for Pharmacological Research
2011-2020
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2019
Mylan (Switzerland)
2017-2018
Weatherford College
2013
Much evidence shows that acute and chronic inflammation in spinal cord injury (SCI), characterized by immune cell infiltration release of inflammatory mediators, is implicated development the secondary phase occurs after trauma worsening damage. Activation microglia/macrophages associated response appears to be a self-propelling mechanism leads progressive neurodegeneration persisting pain state. Recent advances polymer science have provided huge amount innovations leading increased interest...
Astrogliosis has a very dynamic response during the progression of spinal cord injury, with beneficial or detrimental effects on recovery. It is therefore important to develop strategies target activated astrocytes and their harmful molecular mechanisms so as promote protective environment counteract secondary injury. The challenge formulate an effective therapy maximum effects, but reduced side effects. In this study, functionalized nanogel-based nanovector was selectively internalized in...
Polymer functionalization strategies have recently attracted considerable attention for several applications in biomaterials science.
The principles of Refinement, Replacement and Reduction (3R's) should be taken into account when animals must used for scientific purpose. Here, a / Refinement approach was applied to the procedure spinal cord injury (SCI), an animal model in rehabilitation medicine research, order improve quality experiments, avoiding unnecessary suffering. aims this investigation were 1- assess acute surgical pain mice subjected SCI, 2- compare efficacy commonly analgesia (three buprenorphine subcutaneous...
In the injured spinal cord, chondroitin sulfate proteoglycans (CSPGs) are principal responsible of axon growth inhibition and they contribute to regenerative failure, promoting glial scar formation. Chondroitinase ABC (chABC) is known for being able digest proteoglycans, thus degrading favoring axonal regrowth. However, its classic administration invasive, infection-prone clinically problematic. An agarose-carbomer (AC1) hydrogel, already used in SCI repair strategies, was here investigated...
One of the most important drawbacks nanomedicine is related to unwanted rapid diffusion drugs loaded within nanocarriers towards external biological environment, according high clearance body fluids.
Oxidative stress and mitochondrial impairment are the main pathogenic mechanisms of Amyotrophic Lateral Sclerosis (ALS), a severe neurodegenerative disease still lacking effective therapy. Recently, coenzyme-Q (CoQ) complex, key component function redox-state modulator, has raised interest for ALS treatment. However, while oxidized form ubiquinone10 was ineffective in patients modestly mouse models ALS, no evidence reported on effect reduced ubiquinol10, which better bioavailability...
Establishing a common language that allows univocal and objective communication in describing wounds their healing is of utmost importance defining the diagnostic hypothesis proper wound management. To measure level agreement on description wounds, an international study was performed among experts different professional backgrounds several terms used to describe ulcerative lesions. A panel 27 care anonymously completed multiple-choice questionnaire 100 images 50 The participants were asked...