A5061267788- Spinal Cord Injury Research
- Nerve injury and regeneration
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Electrospun Nanofibers in Biomedical Applications
- Graphene and Nanomaterials Applications
- Stroke Rehabilitation and Recovery
- Brain Tumor Detection and Classification
- Mesenchymal stem cell research
- Surfactants and Colloidal Systems
- Innovative Microfluidic and Catalytic Techniques Innovation
- Hydrogels: synthesis, properties, applications
- Intramuscular injections and effects
- Advanced Polymer Synthesis and Characterization
- Pickering emulsions and particle stabilization
- Tissue Engineering and Regenerative Medicine
Mario Negri Institute for Pharmacological Research
2019-2024
Università della Svizzera italiana
2023-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2021
Politecnico di Milano
2019
Astrogliosis has a very dynamic response during the progression of spinal cord injury, with beneficial or detrimental effects on recovery. It is therefore important to develop strategies target activated astrocytes and their harmful molecular mechanisms so as promote protective environment counteract secondary injury. The challenge formulate an effective therapy maximum effects, but reduced side effects. In this study, functionalized nanogel-based nanovector was selectively internalized in...
Abstract Current treatments for modulating the glial‐mediated inflammatory response after spinal cord injury (SCI) have limited ability to improve recovery. This is quite likely due lack of a selective therapeutic approach acting on microgliosis and astrocytosis, glia components most involved trauma, while maximizing efficacy minimizing side effects. A new nanogel that can selectively release active compounds in microglial cells astrocytes developed characterized. The degree selectivity...
Spinal cord injury (SCI) is a devastating condition that can cause significant motor and sensory impairment. Microglia, the central nervous system's immune sentinels, are known to be promising therapeutic targets in both SCI neurodegenerative diseases. The most effective way deliver medications control microglial inflammation through nanovectors; however, because of variability morphology lack standardized techniques, it still difficult precisely measure their activation preclinical models....
Current pharmacological and surgical therapies for the central nervous system (CNS) show a limited capacity to reduce damage progression; that together with intrinsic capability of CNS regenerate greatly reduces hopes recovery. Among all proposed, tissue engineering strategies supplemented therapeutic stem cells remain most promising. Neural are based on development devices presenting optimal physical, chemical, mechanical properties which, once inserted in injured site, can support cells,...
Abstract Bicontinuous jammed emulsions (known as bijels) are Pickering where oil and water both continuous phases. These interconnected structures, stabilized by colloidal nanoparticles at the oil–water interface, have been used in a wide range of applications. Among these, catalysis encapsulation solutes has showed promising potential, but low mechanical properties systems limit their use. Here it is proposed that use hydrophobic monomer able to polymerize bulk form biphasic porous...
Biphasic Porous Structures In article number 2100991, Fabio Pizzetti, Filippo Rossi, and co-workers report biphasic porous structures consisting of monomer (hydrophobic, that can polymerize in bulk condition) water be formed simply by mixing the system using colloid nanoparticles without typical presence surfactants. The produced exhibits high stability at body temperature promising performances for multi-drug delivery approach.