A5043620852- Ionic liquids properties and applications
- Hydrogels: synthesis, properties, applications
- Advanced NMR Techniques and Applications
- Molecular spectroscopy and chirality
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Surfactants and Colloidal Systems
- Advanced Battery Materials and Technologies
- NMR spectroscopy and applications
- Electrochemical Analysis and Applications
- Colorectal Cancer Treatments and Studies
- Drug Solubulity and Delivery Systems
- Endometrial and Cervical Cancer Treatments
- Analytical Chemistry and Chromatography
- Microfluidic and Capillary Electrophoresis Applications
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Ovarian cancer diagnosis and treatment
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Synthesis and Properties of Aromatic Compounds
- Atomic and Subatomic Physics Research
- Material Dynamics and Properties
- Nanoparticle-Based Drug Delivery
- Crystallography and molecular interactions
Politecnico di Milano
2016-2025
University of Florence
2014-2025
Azienda Ospedaliero-Universitaria Careggi
2011-2024
Marconi University
2022
KU Leuven
2019
Curculio Institute
2017
Mylan (Switzerland)
2015-2017
Zero to Three
2015-2016
Tecnologia Energia Ambiente Materiali (Italy)
2016
Mylan (South Africa)
2014-2015
We report on molecular dynamics simulations of the ionic liquid [bmim][BF4] and its mixtures with water, from zero up to 0.5 mol fraction water. All are carried out two published force fields. The results compared each other as well new NMR data same mixtures, whenever possible. perform extensive analyses structural quantities, such pair correlation functions, nearest-neighbor analysis size distribution water clusters formed at higher concentrations. show that almost exclusively by linear...
Lithium salts dissolved in ionic liquids (ILs) are interesting alternatives to the commonly used electrolytes for Li-ion batteries. In this study, solution of Li [bis-(trifluoromethanesulfonyl)imide] (LiTFSI) N-butyl-N-methylpyrrolidinium TFSI (PYR14TFSI) liquid 0.1:0.9 molar ratio is studied by heteronuclear NOE and NMR diffusion measurements. The main purpose spot on interions organization mobility. data support existence strongly coordinated Li+ species, whereas variable temperature...
The effect of the addition lithium nitrate on liquid range and electrical conductivity mixtures a protic ionic liquid, ethylammonium (EAN) with LiNO3 is reported in this work. Moreover, changes these properties upon confinement silica-based matrices are also analysed related to variations microstructure mixtures. Our results show that gelation induces amorphous behaviour all samples, but no significant thermal stability detected. However, important differences gel states were observed. While...
Room-temperature ionic liquids (RTILs) based on the N-butyl-N-methyl pyrrolidinium cation (PYR(14)(+)) combined with three different fluorinated anions have been prepared and characterized by NMR, conductivity, rheological measurements. The are (trifluoromethanesulfonyl)(nonafluorobutanesulfonyl)imide (IM(14)(-)), bis(pentafluoroethanesulfonyl)imide (BETI(-)), bis(trifluoromethanesulfonyl)imide (TFSI(-)). Intermolecular anion-cation nuclear Overhauser enhancements (NOEs) experimentally...
Hydrogels are commonly studied for tissue engineering applications and controlled drug delivery. In order to evaluate their reliability as scaffolds delivery devices, literature describes many release studies performed involving different analytical techniques. However, these experiments can be expensive, time-consuming, often not reproducible. this study, two injectable agar-carbomer-based hydrogels were studied, both being loaded with sodium fluorescein, a harmless fluorophore steric...
Room temperature ionic liquids are one of the most exciting classes materials in last decade. The interest for these low melting, compounds stems from both their technological impact and stimulating plethora structural dynamic peculiarities mesoscopic space-time scales. It is nowadays well-established that they characterised by an enhanced degree order originating inherent amphiphilicity. In this contribution we highlight existence a further complexity when dealing with RTILs bearing medium...
SAXS, <sup>129</sup>Xe NMR and PALS were used to interrogate the relationship between structure, free volume physicochemical properties of ionic liquid mixtures.
Ibuprofen sodium salt (IP) was encapsulated in cyclodextrin nanosponges (CDNS) obtained by cross-linking of β-cyclodextrin with ethylenediaminetetraacetic acid dianhydride (EDTAn) two different preparations: CDNSEDTA 1:4 and 1:8, where the 1: n notation indicates CD to EDTAn molar ratio. The entrapment IP achieved swelling polymers a 0.27 M solution D 2 O, leading colourless, homogeneous hydrogels loaded IP. molecular environment transport properties were studied high resolution magic angle...
The rotational dynamics of the mixture composed deep eutectic solvent (DES) reline, and macrocyclic oligosaccharide β-cyclodextrin (βCD) is investigated at molecular level by NMR relaxation spectroscopy with without known amounts water. progressive addition water affects motion DES βCD in different ways. findings are consistent interacting primarily added reline preserving some degree residual network. Combining this way features individual components may be highly advantageous for future...
Hyaluronic acid (HA) is a versatile biomaterial frequently utilized in regenerative medicine due to its gel-like properties, making it well-suited for clinical applications. However, linear form susceptible rapid enzymatic degradation, limiting longevity within the body. To address this challenge, extensive research has focused on crosslinking mechanisms enhance durability of HA gels. One early approach involved with 1,4-butanediol diglycidyl ether (BDDE) create HA-BDDE, clinically used...
Important classes of antibiotics acting on bacterial cell wall biosynthesis, such as beta-lactams and glycopeptides, are used extensively in therapy now faced with a challenge because the progressive spread resistant pathogens. A discovery program was devised to target novel peptidoglycan biosynthesis inhibitors capable overcoming these resistance mechanisms. The microbial products were first screened according their differential activity against Staphylococcus aureus its L-form. Then,...
Ionic liquids offer the opportunity of tailoring their properties by changing chemical structure cation and anion. Blending two or more adds a further dimension to this "chemical space". Here we present results study three binary one ternary mixture ionic formed N-butyl-N-methylpyrrolidinium with bis(trifluoromethanesulfonyl) imide, bis(pentafluoroethanesulfonyl) imide (trifluoromethanesulfonyl)(nonafluorobutanesulfonyl) imide. We have collected viscosity NMR-based data on ionxion...
We present the characterization of LiX-doped room-temperature ionic liquids (ILs) based on N-butyl-N-methyl pyrrolidinium (PYR14) cation with two fluorinated anions: (trifluoromethanesulfonyl)-(nonafluorobutanesulfonyl)imide (X═IM14) and bis(pentafluoroethanesulfonyl)imide (X═BETI). The new data are also compared previous results PYR14TFSI (bis(trifluoromethanesulfonyl)imide). Their local organization has been investigated via NMR nuclear Overhauser effect (NOE) experiments for {(1)H-(19)F}...
An integrated experimental approach, based on inelastic light-scattering techniques, has been here employed for a multilength scale characterization of networking properties cyclodextrin nanosponges, new class cross-linked polymeric materials built up from natural oligosaccharides cyclodextrins. By using Raman and Brillouin scattering experiments, we performed detailed inspection the vibrational dynamics these polymers over wide frequency window ranging gigahertz to terahertz, with aim...
Polymeric micelles, in particular PEO-PPO-based Pluronic, have emerged as promising drug carriers, while cyclodextrins (CD), cyclic oligosaccharides with an apolar cavity, long been used for their capacity to form inclusion complexes drugs. Dimethylated β-cyclodextrin (DIMEB) has the fully breakup F127 Pluronic this effect is substantially hindered if drugs are loaded within micellar aggregates. Four were studied at physiological temperature: lidocaine (LD), pentobarbital sodium salt (PB),...
Stable hydrogels with tunable rheological properties were prepared by adding Ca
Within the OMITERC prospective study (OMIcs application from solid to liquid biopsy for a personalised ThERapy of Cancer), we explored prognostic role encompassing cell-free DNA (cfDNA) and circulating tumour cells (CTCs) in KRAS mutated metastatic colorectal cancer (mCRC). We defined workflow including pre-analytical analytical procedures collecting blood before therapy every 3 months until disease progression (PD). CTCs were counted by CellSearch® isolated DEPArray™. NGS sequencing cfDNA...
Abstract Current treatments for modulating the glial‐mediated inflammatory response after spinal cord injury (SCI) have limited ability to improve recovery. This is quite likely due lack of a selective therapeutic approach acting on microgliosis and astrocytosis, glia components most involved trauma, while maximizing efficacy minimizing side effects. A new nanogel that can selectively release active compounds in microglial cells astrocytes developed characterized. The degree selectivity...
Natural deep eutectic solvents (NADES) are an increasingly appreciated class of mixtures composed by eco-sustainable and environmentally responsible components with hydrogen bonding (HB) donor acceptor capabilities that enable the establishment extended HB network. The latter eventually leads to a substantial drop in mixture melting point respect one ideal mixture. Water-based NADES represent exciting system responds above mentioned criteria contain water as major component, rather than...