The traditional use of organic solvents in various branches industry is being rethought as these compounds very often display high volatility, toxicity and lipophilicity (related to the ability interact with biological membranes). More recently, developments field Green Chemistry are focusing on design more sustainable cost-effective solvent alternatives like Ionic Liquids (ILs), bio-based natural deep eutectic (NADESs). present study aimed at performing an ecotoxicological screening 15...

Ibuprofen sodium salt (IP) was encapsulated in cyclodextrin nanosponges (CDNS) obtained by cross-linking of β-cyclodextrin with ethylenediaminetetraacetic acid dianhydride (EDTAn) two different preparations: CDNSEDTA 1:4 and 1:8, where the 1: n notation indicates CD to EDTAn molar ratio. The entrapment IP achieved swelling polymers a 0.27 M solution D 2 O, leading colourless, homogeneous hydrogels loaded IP. molecular environment transport properties were studied high resolution magic angle...

The rotational dynamics of the mixture composed deep eutectic solvent (DES) reline, and macrocyclic oligosaccharide β-cyclodextrin (βCD) is investigated at molecular level by NMR relaxation spectroscopy with without known amounts water. progressive addition water affects motion DES βCD in different ways. findings are consistent interacting primarily added reline preserving some degree residual network. Combining this way features individual components may be highly advantageous for future...

The consideration towards waste cooking oils is changing from hazardous to valuable raw material for industrial application. During the last 5 years, some innovative processes based on employment of recycled oil have appeared in literature. In this review article, most recent and applications are reported discussed. These include production bioplasticizers, application chemicals derived as energy vectors use a solvent pollutant agents.

Novel choline acetate based deep eutectic solvents (DESs) solubilize hemicellulose up to 45 wt% at 80 °C. A PoC test on Kraft cellulose illustrates the cellulose/hemicellulose separation.

An integrated approach, based on quantitative transmission mode powder X-ray diffraction (PXRD) combined with multivariate statistical analysis, has been applied to cellulose obtained from three different sources correlate the mercerization degree and crystallinity type, temperature, reaction time. The effects of experimental conditions two outcomes were studied by design experiments (DoE) surface responding analysis (SRA) principal component (PCA). SRA showed a marked influence type (wood...

Stable hydrogels with tunable rheological properties were prepared by adding Ca

The chemical composition and the color of samples waste cooking oils (WCOs) were determined prior to after filtration on two different pads bentonite differing in particle size. volatile fraction was monitored by headspace solid-phase microextraction (HS-SPME) coupled with gas-chromatography, while variation main components analyzed 1H NMR. Both techniques allowed detection some decomposition products, such as polymers, terpenes, derivatives Maillard process. analysis treatment revealed a...

Efficient renewable and nontoxic absorbents can now be designed to eliminate air pollutants such as volatile organic compounds (VOCs) from confined atmospheres. New hybrid materials result the combination of deep eutectic systems (DESs) with well-known VOC capture agents like β-cyclodextrin (βCD). However, a question arises: does βCD retain its encapsulation ability in DESs? Multiple nuclear magnetic resonance (NMR) techniques are used here demonstrate formation inclusion complexes two VOCs,...

The reaction of β-cyclodextrin with suitable bifunctional cross-linkers (such as carboxylic acids dianhydrides) provides 3D nanoporous polymers referred to cyclodextrin nanosponges (CDNS). swelling ability many CDNS can be exploited confine small active molecules, such drugs, in the resulting hydrogel, thus providing drug-loaded hydrogels. This raises an increasing interest toward hydrogels biomaterials for controlled drug delivery due their nontoxicity, biocompatibility, and...

Fluorinated room temperature ionic liquids (FRTILs) represent a class of solvent media that are attracting great attention due to their IL-specific properties as well features stemming from fluorous nature. Medium-to-long tails constitute well-defined apolar moiety in the otherwise polar environment. Similarly case alkyl tails, such chains expected result formation self-assembled domains. So far, however, no direct experimental observation has been made existence structural heterogeneities...

A new hyper-branched water-soluble polymer was synthesized by reacting β-cyclodextrin with pyromellitic dianhydride beyond the critical conditions that allow phenomenon of gelation to occur. The molar ratio between monomers is a crucial parameter rules process. Nevertheless, concentration in solvent phase plays key role as well. Hyper-branched β-cyclodextrin-based polymers were obtained performing syntheses excess and cross-linking agent, for dilution determined experimentally. very high...

In drug-delivery systems, drug transport is a key step, but the interpretation of mechanism still controversial. Here, we investigated promising hydrogel library loaded with anticonvulsant ethosuximide (ESM). The self-diffusion coefficient ESM was measured using two methods: direct and advanced measurement pulsed field gradient spin-echo (PFGSE) method, an NMR spectrometer equipped high-resolution magic angle spinning (HR-MAS) probe, indirect one based on fitting in vitro data. Starting from...

Hepta-TEMPO β-CD has a molecular effective magnetic moment of 4.2 <italic>μ</italic>_B that is responsible NMR relaxivity up to 1.60 mm⁻¹ s⁻¹, not far from the values reported for Gd-based contrast agents, thus resulting promising candidates as non-toxic MRI agents.

In contrast to most pharmaceutical agents, the major anticoagulant agent, heparin, lacks a uniquely defined chemical structure. It is an inherently structurally varying, poly-disperse polymer, rendering quality control problematic. Structural modifications introduced during manufacture and presence of possible contaminants are dangers. The comparison any heparin test sample library bona fide, but intrinsically variable heparins, limited fundamentally measuring degree similarity between them....

The first use of statistical correlation spectroscopy to extract chemical information from 2D-HSQC spectra, termed HSQC (HSQCcos), is reported. HSQCcos illustrated using heparin, a heterogeneous polysaccharide, whose diverse composition causes signals in spectra disperse. has been used probe the chain modifications that cause this effect and reveals hitherto unreported structural details. An interesting finding was signal for position 2 trisulfated glucosamine [N-, 3-O-, 6-O-sulfated] (A*)...

Two different formulations of cyclodextrin nanosponges (CDNS), obtained by polycondensation β-cyclodextrin with ethylenediaminetetraacetic acid dianhydride (EDTAn), were treated aqueous solutions ibuprofen sodium salt (IbuNa) affording hydrogels that, after lyophilisation, gave two solid CDNS-drug formulations. 1 H fast MAS NMR and 13 C CP-MAS spectra showed that IbuNa was converted in situ into its acidic dimeric form (IbuH) freeze-drying. also indicated the structure nanosponge did not...

Cell metabolism is a key determinant factor for the pluripotency and fate commitment of Stem Cells (SCs) during development, ageing, pathological onset progression. We derived cultured selected subpopulations rodent fetal, postnatal, adult Neural SCs (NSCs) postnatal glial progenitors, Olfactory Ensheathing (OECs), respectively from subventricular zone (SVZ) olfactory bulb (OB). lysates were analyzed by proton Nuclear Magnetic Resonance (1H-NMR) spectroscopy leading to metabolites...

The thermodynamics of halogen bonding a series isostructural Group 10 metal pincer fluoride complexes the type [(3,5-R2 -tBu POCOPtBu )MF] (3,5-R2 =κ3 -C6 HR2 -2,6-(OPtBu2 )2 with R=H, tBu, COOMe; M=Ni, Pd, Pt) and iodopentafluorobenzene was investigated. Based on NMR experiments at different temperatures, all 1-tBu (R=tBu, M=Ni), 2-H (R=H, M=Pd), 2-tBu 2-COOMe (R=COOMe, M=Pd) 3-tBu M=Pt) form strong bonds Pd showing significantly stronger binding to iodopentafluorobenzene. Structural...

Abstract To address the increasing need for improved tissue substitutes, engineering seeks to create synthetic, three‐dimensional scaffolds made from polymeric materials able incorporate cells and drugs. The interpretation of transport phenomena is a key step, but comprehensive theoretical data still missing many issues related these systems are unsolved. In particular, contribution solute–solute interactions not yet completely understood. Here, we investigate promising agar–carbomer (AC)...