A5055808327- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- Periodontal Regeneration and Treatments
- Graphene and Nanomaterials Applications
- Dental materials and restorations
- Nanoparticle-Based Drug Delivery
- Advanced Drug Delivery Systems
- Electrospun Nanofibers in Biomedical Applications
- Chemical Synthesis and Characterization
- Hemostasis and retained surgical items
- Silk-based biomaterials and applications
- Surgical Sutures and Adhesives
- Animal Genetics and Reproduction
- Wound Healing and Treatments
- Additive Manufacturing and 3D Printing Technologies
- Advanced Nanomaterials in Catalysis
- Algal biology and biofuel production
- Inorganic Chemistry and Materials
- Protease and Inhibitor Mechanisms
- Engineering Technology and Methodologies
- Hydrogels: synthesis, properties, applications
- Oral and Maxillofacial Pathology
- Oral and gingival health research
- Orthopaedic implants and arthroplasty
- Microbial Community Ecology and Physiology
Riga Technical University
2015-2025
Innovation (Latvia)
2016-2024
Stanford University
2015-2018
Palo Alto Institute
2017
Creative Commons
2016
Coastal countries have traditionally relied on the existing marine resources (e.g., fishing, food, transport, recreation, and tourism) as well tried to support new economic endeavors (ocean energy, desalination for water supply, seabed mining). Modern societies lifestyle resulted in an increased demand dietary diversity, better health well-being, biomedicines, natural cosmeceuticals, environmental conservation, sustainable energy sources. These societal needs stimulated interest of...
Cannabidiol (CBD) is recognized for its therapeutic properties in various conditions. However, CBD's limited water solubility and sensitivity to environmental stresses hinder efficacy bioavailability. Encapsulation drug delivery systems, particularly liposomes, offers a promising solution. This study aims prepare CBD-containing liposomes using commercially used lipids distearoyl phosphatidylcholine (DSPC) dipalmitoyl (DPPC), 1,2 distearoyl-sn-glycero-3...
The last twenty years have witnessed great advances in biology, medicine, and materials science, leading to the development of various nanoparticle (NP)-mediated drug delivery systems. Innovation science has led generation biodegradable, biocompatible, stimuli-responsive, targeted However, currently available nanotherapeutic technologies are not efficient, which culminated failure their clinical trials. Despite huge efforts devoted nanotherapeutics, only a small amount injected material...
Marine organisms produce a vast diversity of metabolites with biological activities useful for humans, e.g. cytotoxic, antioxidant, anti-microbial, insecticidal, herbicidal, anticancer, pro-osteogenic and pro-regenerative, analgesic, anti-inflammatory, anti-coagulant, cholesterol-lowering, nutritional, photoprotective, horticultural or other beneficial properties. These could help satisfy the increasing demand alternative sources nutraceuticals, pharmaceuticals, cosmeceuticals, food, feed,...
Biomass is defined as organic matter from living organisms represented in all kingdoms. It recognized to be an excellent source of proteins, polysaccharides and lipids and, such, embodies a tailored feedstock for new products processes apply green industries. The industrial focused on the valorization terrestrial biomass are well established, but marine sources still represent untapped resource. Oceans seas occupy over 70% Earth’s surface used intensively worldwide economies through fishery...
Platelet-rich fibrin (PRF), derived from human blood, rich in wound healing components, has drawbacks direct injections, such as rapid matrix degradation and growth factor release. Marine polysaccharides, mimicking the extracellular matrix, show promising potential tissue engineering. In this study, we impregnated self-assembled fucoidan/chitosan (FU_CS) hydrogels with PRF obtaining PRF/FU_CS hydrogels. Our objective was to analyze properties of a hydrogel sustained release factors that...
In this work, copper whitlockite (Cu-WH, Ca 18 Cu 2 (HPO 4 ) (PO 12 was successfully synthesized and comprehensively characterized. This material is a copper-containing analog of the well-known biomineral magnesium (Ca Mg ).
Due to its bioactivity, hydroxyapatite (HAp) is one of the most perspective materials for controlled drug delivery.Biodegradable polymers like chitosan and sodium alginate are used as coating ceramic scaffolds.In this work application HAp/sodium or composite which provide lidocaine release discussed.The hydrochloride were incorporated in porous HAp scaffolds.Release was determined using high-performance liquid chromatography (HPLC).Depending on polymer type coating, crystal structure...
Autologous platelet-rich fibrin (PRF) is derived from the blood and its use in bone tissue engineering has emerged as an effective strategy for novel drug growth factor delivery systems. Studies have approved that combined therapy with PRF ensures higher biological outcomes, but patients still undergo additional treatment antibiotic drugs before, during, even after implantation of biomaterials PRF. These systematically used spread throughout lead not only to positive effects may also induce...
The aim of this study was to investigate the change in clindamycin phosphate antibacterial properties against Gram-positive bacteria using platelet-rich fibrin as a carrier matrix, and evaluate changes antibiotic within matrix. CLP its combination with PRF were tested microdilution test reference cultures clinical isolates Staphylococcus aureus (S. aureus) or epidermidis epidermidis). Fourier-transform infrared spectroscopy (FTIR) scanning electron microscope (SEM) analysis done PRF_CLP...
Despite the bone ability of self-regeneration, large defects require surgical intervention. Likewise, when it comes to osteoporotic fractures, new approaches should be considered a supportive mechanism for surgery. In recent years, more and attention has been attracted advanced drug delivery systems local osteoporosis treatment, combining appropriate biomaterials with antiosteoporotic drugs, allowing simultaneously regenerate locally treat osteoporosis. Within current research, hyaluronic...
It has been recognized that the operative stabilization of osteoporotic fractures should be followed up with an appropriate osteoporosis treatment in order to decrease risk repeated fractures. Despite good clinical results strontium ranelate (SrRan) towards treatment, high drug doses and long period cause increased serious side effects. Novel local SrRan/poly(lactic acid) (SrRan/PLA) delivery systems containing from 3.57 ± 0.28 wt% 24.39 0.91 active substance were developed. In resemble...
In the present study, impact of sintering temperature on phase composition and antibacterial properties silver-doped hydroxyapatite (HAp/Ag) samples was investigated. HAp/Ag containing 0.2 1.2 % silver prepared using a modified wet chemical precipitation method. The surface morphology inner structure sintered were discussed. X-ray powder diffraction (XRD) scanning electron microscopy (SEM) studies showed that, after process, contained oxide phase, which not observed in raw materials. Phase...
The aim of the study was to perform treatment juniper wood obtain material with a density and mechanical properties comparable bone, thus producing potential for use in osteosynthesis bone implants. In first step, partial delignification sample obtained by Kraft cooking. second step extraction ethanol, ethanol-water mixture, saline, water prevent release soluble compounds increase biocompatibility. last thermal densification at 100 °C 24 h implemented. results dry state are equivalent bone....
Abstract Synthesis, solubility and cytotoxicity evaluation of anionic phosphonates derived from betulin, betulinic acid, oleanolic acid ursolic is reported. Phosphonate moieties were successfully installed at terpenoid C28 by carboxylic deprotonation/alkylation sequence using (dimethoxyphosphoryl)methyl trifluoromethanesulfonate as alkylation reagent. Also, betulin-derived ether-linked bis-phosphonate obtained characterized. After demethylation in the presence TMSI resulting phosphonic acids...
Magnetic Resonance Imaging (MRI) has come to be known as a unique radiological imaging modality because of its ability perform tomographic body without the use any harmful ionizing radiation.The radiologists MRI gain insight into anatomy organs, including brain, while biomedical researchers explore better understanding brain structure and function.However, due limited resolution contrast, conventional fails show microstructure.Diffusion Tensor (DTI) harnesses power deduce diffusion dynamics...