A5024600266- Hydrogels: synthesis, properties, applications
- Air Quality and Health Impacts
- Phytochemicals and Antioxidant Activities
- Occupational and environmental lung diseases
- Essential Oils and Antimicrobial Activity
- RNA modifications and cancer
- Biopolymer Synthesis and Applications
- Bee Products Chemical Analysis
- Occupational exposure and asthma
- Bone Tissue Engineering Materials
- Skin Protection and Aging
- Occupational Health and Safety Research
- Phytochemical and Pharmacological Studies
- Plant tissue culture and regeneration
- biodegradable polymer synthesis and properties
- Nail Diseases and Treatments
- Transgenic Plants and Applications
- Advanced Drug Delivery Systems
- Antimicrobial agents and applications
- Wound Healing and Treatments
- Cancer-related gene regulation
- Biochemical and Structural Characterization
- Viral gastroenteritis research and epidemiology
- Seaweed-derived Bioactive Compounds
- Phytochemistry Medicinal Plant Applications
University of Latvia
2012-2024
Pauls Stradiņš Clinical University Hospital
2013-2020
State Education Development Agency
2012
Riga Technical College
2012
The design of multifunctional hydrogels based on bioactive hyaluronic acid (HA) and antibacterial cationic polymer ɛ-poly-l-lysine (ε-PL) is a promising tool in tissue engineering applications. In the current study, we have designed ɛ-polylysine composite hydrogel systems with cell attractive properties. Two distinct crosslinking approaches were used: physical electrostatic attractions chemical charged functional groups (-NH2 -COOH). impact strategy fabricated molecular structure, swelling...
Viral mRNA cap methyltransferases (MTases) are emerging targets for the development of broad-spectrum antiviral agents. In this work, we designed potential SARS-CoV-2 MTase Nsp14 and Nsp16 inhibitors by using bioisosteric substitution sulfonium amino acid substructures cosubstrate S-adenosylmethionine (SAM), which serves as methyl donor in enzymatic reaction. The synthetically accessible target structures were prioritized molecular docking. Testing inhibitory activity synthesized compounds...
SARS-CoV-2 nsp14 guanine-N7-methyltransferase plays an important role in the viral RNA translation process by catalyzing transfer of a methyl group from S-adenosyl-methionine (SAM) to mRNA cap. We report structure-guided design and synthesis 3-(adenosylthio)benzoic acid derivatives as methyltransferase inhibitors resulting compound 5p with subnanomolar inhibitory activity improved cell membrane permeability comparison parent inhibitor. Compound acts bisubstrate inhibitor targeting both SAM...
For sustainable sea buckthorn (Hippophae rhamnoides) berry production, the task at hand is to find an application for large amount of biomass waste arising harvesting. Sea (SBT) vegetation currently poorly studied. The purpose this research was assess composition and potential SBT twigs as a source valuable biologically active substances. Water 50% EtOH extracts three Latvian cultivars with high yield quality, popular cultivation in many countries (H. rhamnoides ‘Maria Bruvele’, ‘Tatiana’,...
It has now been proven that many pathogens cause infections and inflammation gradually mutate become resistant to antibiotics. Chemically synthesized drugs treating most often only affect symptoms, but side effects could lead the failure of human organs' functionality. On other hand, plant-derived natural compounds have a long-term healing effect. was shown sea buckthorn (SBT) twigs are rich source biologically active compounds, including oligomeric proanthocyanidins (PACs). This study aimed...
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses mRNA capping to evade the human immune system. cap formation is performed by SARS-CoV-2 methyltransferases (MTases) nsp14 and nsp16, which are emerging targets for development of broad-spectrum antiviral agents. Here, we report results from high-throughput virtual screening against these two enzymes. docking seven million commercially available drug-like compounds S-adenosylmethionine (SAM) co-substrate analogues both...
Bacterial infections are a prevalent complication after primary viral respiratory and associated with high morbidity mortality. Antibiotics widely used against bacterial pathogens; however, the rise in antibiotic-resistant strains urges us to search for new antimicrobial compounds, including ones that act synergistically antibiotics. In this study, minimal inhibitory (MIC) bactericidal (MBC) concentrations of polyphenol-rich complex green propolis, Tabebuia avellanedae bark, Olea europaea...
In this research, we have reported the valorization possibilities of Matricaria recutita white ray florets using supercritical fluid extraction (SFE) with CO2. Experiments were conducted at temperatures 35-55 °C and separation pressures 5-9 MPa to evaluate their impact on chemical composition biological activity extracts. The total obtained yields varied from 9.76 18.21 g 100 g-1 DW input. greatest yield was 9 pressure 55 in tank. all extracts, contents phenols, flavonoids, tannins, sugars...
The reduction of tissue cytotoxicity and the improvement cell viability are utmost significance, particularly in realm green chemistry. Despite substantial progress, threat local infections remains a concern. Therefore, hydrogel systems that provide mechanical support harmonious balance between antimicrobial efficacy greatly needed. Our study explores preparation physically crosslinked, injectable, hydrogels using biocompatible hyaluronic acid (HA) ε-polylysine (ε-PL) different weight ratios...
Synthetic hydroxyapatite nanoparticles (nHAp) possess compositional and structural similarities to those of bone minerals play a key role in regenerative medicine. Functionalization calcium phosphate biomaterials with Sr,
Aromatic and medicinal plants are a great source of useful bioactive compounds for use in cosmetics, drugs, dietary supplements. This study investigated the potential using supercritical fluid extracts obtained from
Despite the bone ability of self-regeneration, large defects require surgical intervention. Likewise, when it comes to osteoporotic fractures, new approaches should be considered a supportive mechanism for surgery. In recent years, more and attention has been attracted advanced drug delivery systems local osteoporosis treatment, combining appropriate biomaterials with antiosteoporotic drugs, allowing simultaneously regenerate locally treat osteoporosis. Within current research, hyaluronic...
Background:The role of oncolytic viruses in cancer treatment is increasingly studied.The first virus (Rigvir®, ECHO-7) was registered Latvia over a decade ago.In recent retrospective study Rigvir® decreased mortality 4.39-6.57-fold stage IB-IIC melanoma patients.The aims the present are to test effect on cell line viability vitro and visualize cellular presence by immunocytochemistry.Methods: The cytolytic FM-9, RD, AGS, A549, HDFa, HPAF-II, MSC, MCF7, HaCaT, Sk-Mel-28 lines measured using...
Skin and soft tissue infections (SSTIs) acne are among the most common skin conditions in primary care. SSTIs caused by ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter sp.) can range severity, treating them is becoming increasingly challenging due to growing number of antibiotic-resistant pathogens. There also a rise strains Cutibacterium acne, which plays role development acne. Antimicrobial...
For skin health promotion and cosmetic applications, combinations of plant cell extracts are extensively utilized. As most natural ingredient suppliers offer crude from individual plants or specific isolated compounds, the potential interactions between them assessed in development phase products. The industry seeks extract that have undergone optimization scrutiny for their bioactivities. This study presents a combination two sustainably produced botanical ingredients outlines chemical...
This paper reports about cotton textile modification by sol-gel technology with the purpose of obtaining antibacterial properties, evaluation properties and dermal toxicity tests Zn Si coating. Antibacterial against pathogenic microorganisms Pseudomonas aeruginosa, Staphylococcus aureus, Escherichia coli made using Parallel streak method in accordance ATCC147 standard. For more specific coated textile, vitro cytotoxicity test epidermal HaCat cells was done. It is concluded that coatings...
The present study provides an assessment of extracts six medicinal plants for their applicability in cosmetic formulations aimed at anti-UV protection and anti-acne treatment. Ethanol Chelidonium majus L., Myrtus communis Hamamelis virginiana Juniperus Alchemilla vulgaris Ilex paraguariensis are analysed the phytochemical content, antimicrobial activity, antiradical activity kinetics. composition is investigated by LC-MS analysis most active antioxidants plant determined online HPLC-DPPH...
Inhalation is the main route of exposure to airborne pollutants. To evaluate safety and assess risks occupational hazards different testing approaches are used. 3D airway epithelial tissues allow mimic conditions in vitro, generates human-relevant toxicology data, allows elucidate mode action Gillian3500 pumps were used collect particulate from woodworking metalworking environments. EpiAirway model half working day (4 h), full (8 3 exposures Tissue viability was assessed using an MTT assay....