A5100405366- Ultrasound Imaging and Elastography
- Ultrasound and Hyperthermia Applications
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Microbial Inactivation Methods
- Cardiac Imaging and Diagnostics
- Ultrasonics and Acoustic Wave Propagation
- Colorectal Cancer Surgical Treatments
- Inflammasome and immune disorders
- Radiomics and Machine Learning in Medical Imaging
- interferon and immune responses
- Microfluidic and Bio-sensing Technologies
- Tendon Structure and Treatment
- Anorectal Disease Treatments and Outcomes
- Cardiovascular Function and Risk Factors
- Marine Sponges and Natural Products
- Cancer Cells and Metastasis
- Electromagnetic Fields and Biological Effects
- Meat and Animal Product Quality
- Pericarditis and Cardiac Tamponade
- Cardiac Valve Diseases and Treatments
- Listeria monocytogenes in Food Safety
- Cancer-related molecular mechanisms research
- Gout, Hyperuricemia, Uric Acid
- Pancreatic and Hepatic Oncology Research
Second Affiliated Hospital of Guangzhou Medical University
2015-2024
Guangzhou Medical University
2015-2024
Stony Brook University
2022
Eugene Applebaum College of Pharmacy and Health Sciences
2022
Wayne State University
2022
Crown Bioscience (China)
2018
China Agricultural University
2014
Objective. To explore the feasibility of serum albumin (Alb) and left ventricular ejection fraction (LVEF) in predicting all-cause death (ACD) patients with stable coronary artery disease (SCAD). Methods. Patients SCAD were divided into 4 groups according to their Alb LVEF levels: Group A: ≤4 g/dL > 50%; B: ≤50%; C: >4 D: >50%. The K–M curve log-rank test used compare ACD among four over three years. Receiver operating characteristic (ROC) curves efficacy combination either or...
Objectives The aims of this study were to investigate the value applying quasistatic ultrasound elastography for examination scrotal lesions, features normal testes on elastography, and establish whether testicular epididymal lesions had specific elastographic features. Methods We screened 1073 patients who underwent color Doppler sonographic examinations epididymides in our hospital performed evaluate their Measurement data expressed as mean ± SD. For intergroup comparisons, we used paired...
Hepatocellular carcinoma (HCC) is the fifth most common form of cancer and third frequent cause cancer-associated mortality worldwide. We isolated aaptamine from marine sponge Aaptos, synthesized derivatives this compound. Aaptamine synthetic displayed various biological activities. This represents first account studies on effects its in hepatocarcinogenesis. In study, Cell Counting Kit (CCK8) was used to evaluate anti-proliferative effect HCC vitro. Additionally, a subcutaneous xenograft...
To study the safety, feasibility and skin effects of irreversible electroporation (IRE) for breast tissue cancer in animal models. Eight pigs were used this study. IRE was performed on left breasts with different skin–electrode distances, right as controls. The electrodes placed 1–8 mm away from skin, an electrode spacing 1.5–2 cm. Imaging pathological examinations at specific time points follow-up evaluation. Vital signs, damage, changes ablation efficacy also closely observed. rabbit...
Objectives To assess the correlation between endorectal ultrasound (ERUS) and magnetic resonance imaging (MRI) in predicting circumferential resection margin (CRM) status of patients with mid‐low rectal cancer without preoperative chemoradiotherapy. Methods Twenty who did not receive chemoradiotherapy underwent ERUS MRI examinations before total mesorectal excision from May 2018 to April 2019 were included this study. The patient tumor characteristics, lymph nodes, stages, predictors CRM...
In this report, we provide evidence showing diminished expression of the mineral dust-induced gene (mdig), a previously identified oncogenic gene, in human triple negative breast cancer (TNBC). Using mouse model orthotopic xenograft TNBC MDA-MB-231 cells, demonstrate that mdig promotes growth primary tumors but inhibits metastasis these cells vivo. Knockout resulted an enhancement H3K36me3 genome and upregulation some X chromosome-linked genes for cell motility, invasion, metastasis....
To develop and validate a three-dimensional ultrasound (3D US) radiomics nomogram for the preoperative prediction of extrathyroidal extension (ETE) in papillary thyroid cancer (PTC).This retrospective study included 168 patients with surgically proven PTC (non-ETE, n = 90; ETE, 78) who were divided into training (n 117) validation 51) cohorts by random stratified sampling strategy. The regions interest (ROIs) obtained manually from 3D US images. A larger number radiomic features...
Objective This study aimed to investigate the application value of shear wave elastography in examining normal testes and inflammatory epididymal tail masses. Methods We examined 110 healthy male volunteers (with a total 220 testes) 25 patients with epididymitis via conventional scrotal ultrasonography elastography. The mean ( E ), minimal min maximal max standard deviation SD ) values elasticity were acquired. masses assessed at initial diagnosis, weeks 1 2 anti-inflammatory treatment, upon...
. Pyroptosis is closely related to many chronic diseases including atherosclerosis, but the potential pathomechanisms are still unclear. This research aimed explore how lncRNAs may contribute pyroptosis and mechanisms. We performed in vitro assays investigate effects of a relatively newly discovered lncRNA, NEXN-AS1, on pyroptosis. Two types vascular wall cells, namely, human smooth muscle cells (VSMCs) endothelial (ECs), were used as cell models this study. A previously constructed...
Kidney transplantation is one of the most effective ways to treat end-stage kidney disease. However, 5000 renal transplant recipients start or restart dialysis because chronic allograft nephropathy (CAN) every year in United States. Detecting changes stiffness transplanted kidneys can help diagnose disease.To explore after using shear wave elastography (SWE).This study conducted consecutive follow-up observations on 10 patients transplantation. SWE examination was performed first week,...
Purpose This study aimed to evaluate stiffness changes of rabbit subcutaneous VX 2 tumors before and after irreversible electroporation (IRE) ablationby shearwave ultrasound elastography (SWE). Methods IRE was performed on 20 subcutaneously implanted in rabbits (R-SIVX ). Tumor measured by SWE at different time points (before IRE,120minutes IRE,7 days 14 IRE). Results Before IRE, the mean (E ) (10.45 ± 1.07) KPa. 120 minutes I RE, E obviously rose (70.53 9.87) 7 decreased (40.22 9.01) (15.17...
Development of a radiomics model for predicting lymph node metastasis status in rectal cancer patients based on 3-dimensional endoanal ultrasound images.This study retrospectively included 79 (41 with positive and 38 negative) diagnosed our hospital from January 2018 to February 2022. The tumor's region interest is first delineated by radiologists, which features are extracted. Radiomics were then selected independent samples t-test, correlation coefficient analysis between features, least...
Objective To use shear wave elastography to monitor the effect of different doses muscle relaxant on stiffiness tissue in vivo. Methods 10 healthy New Zealand white rabbits were selected, muscles thigh was measured by France Supersonic diasonograph. Unilateral given injection 0.3 mg/kg atracurium besylate, repeated five minutes later. The after each injection. analyzed. Results Before injection, Emean value (13.2±1.5)kPa, Esd (0.16±0.02)kPa; those first (10.0±3.2)kPa and...
Abstract Recently approved cancer immunotherapy drugs have been shown to not only suppress tumor growth but also prolong survival of patients with various types. More and more relevant sophisticated preclinical models are required by the I/O drug discovery industry. Different strategies humanized mouse model systems published, including human hematopoietic stem cell (HSC) PBMC reconstituted models; each has advantages disadvantages. Compared HSC humanization, using cells reconstitute immune...
Abstract Despite the unprecedented success of immune checkpoint blockade therapy in patients with various cancer types, a lack effective preclinical mouse models remains major challenge for development novel immunotherapeutics. Different strategies to humanize immunodeficient model systems have been reported, including replenishment human hematopoietic stem cells (HSC) or PBMC, as well chimeric harboring targets immunocompetent mice. CrownBio has successfully established number...
Objective To analyze the association between blood vitamin D level and carotid atherosclerosis by Meta analysis. Methods Chinese English literature prior to April 2016 on were searched collected. Stata 12.0 was used for data analysis. Cochrane's Q I2 statistics evaluate heterogeneity, subgroup analysis sensitivity explore sources of heterogeneity. Publication bias calculated funnel plot, Begg rank correlation test. Results A total 3 articles considered totally 730 cases enrolled...
：Coronary heart disease (CHD) affects a wide population and has high mortality rate, which seriously threatens the life safety of patients. Early diagnosis effective treatment can significantly improve survival prognosis CHD At present, it is mainly judged by detecting various myocardial biomarkers, movement coronary blood flow. Stress echocardiography (SE) one commonly used detection methods. It not only judge severity stenosis, but also evaluate distinguish hibernating myocardium stunned...