A5025134376- Mesenchymal stem cell research
- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Neonatal Respiratory Health Research
- Reproductive System and Pregnancy
- Chronic Myeloid Leukemia Treatments
- Cancer-related molecular mechanisms research
- Lymphoma Diagnosis and Treatment
- Immune cells in cancer
- RNA Research and Splicing
- Autoimmune and Inflammatory Disorders Research
- Immune Cell Function and Interaction
- interferon and immune responses
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Antifungal resistance and susceptibility
- Histone Deacetylase Inhibitors Research
- Parvovirus B19 Infection Studies
- Multiple Myeloma Research and Treatments
- Retinoids in leukemia and cellular processes
- Lung Cancer Treatments and Mutations
- Tissue Engineering and Regenerative Medicine
- Protein Degradation and Inhibitors
- Pneumocystis jirovecii pneumonia detection and treatment
- PI3K/AKT/mTOR signaling in cancer
- Barrier Structure and Function Studies
Southern Medical University
2015-2024
Nanfang Hospital
2015-2024
Exosomes are cell-derived vesicles and abundant in biological fluids; they contain RNA molecules which may serve as potential diagnostic biomarkers 'precision medicine'. To promote the clinical application of exosomal (exoRNA), many isolation methods must be compared validated. cell culture medium (CCM) serum isolated using ultracentrifugation (UC), ExoQuick or Total Exosome Isolation Reagent (TEI), exoRNA extracted TRIzol-LS, SeraMir, (TER), HiPure Liquid RNA/miRNA kit (HLR), miRNeasy...
Intracerebral hemorrhage (ICH) has a high mortality and disability rate. Fewer studies focus on white matter injury (WMI) after ICH, especially the corticospinal tract (CST) located in spinal cord, which correlates with motor impairments. Recent have shown that gut microbiota dysbiosis occurs ICH. Furthermore, NLRP3 inflammasome can be activated resulting inflammatory cascade reactions aggravating brain injury. However, no direct causal correlation among inhibition, altered microbiota, CST...
Acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation poses one of the most vexing challenges. Gut microbiota dysbiosis can proceed aGVHD and mesenchymal cells (MSCs) have promising therapeutic potential for aGVHD. However, whether hAMSCs affect gut during mitigation remains unknown. Accordingly, we sought to define effects underlying mechanisms human amniotic membrane-derived MSCs (hAMSCs) regulating intestinal immunity in By establishing humanized...
Abstract Purpose T(8;21)(q22;q22.1)/AML1-ETO positive acute myeloid leukemia (AE-AML) is sensitive to conventional chemotherapy with a favorable prognosis. However, recent small case reports suggest the limited effectiveness of venetoclax (VEN) and hypomethylating agents (HMA) in treating AE-AML. The aim this retrospective study was evaluate VEN plus AZA (VA) AE-AML explore whether adding homoharringtonine (HHT) VA (VAH) could improve response. Methods Patients who received HHT or regimens...
Venetoclax (VEN), a B-cell lymphoma 2 (BCL-2) selective inhibitor, is widely used for treating acute myeloid leukemia (AML) with promising results. However, the anti-leukemic effect of VEN in relapsed/refractory (R/R)- AML requires improvement. In this study, we observed that combining homoharringtonine (HHT) plus azacitidine resulted significantly higher response and better survival than VA alone patients R/R-AML. Basic research indicates HHT combined has highly synergistic against both...
The abnormal proliferation of vascular smooth muscle cells (VSMCs) is crucial in the atherosclerosis. Although long noncoding RNAs (lncRNAs) are implicated a variety diseases, their roles activation VSMCs and disorder diseases not well understood. In addition, heterogeneous nuclear ribonucleoprotein A2/B1 (hnRNPA2/B1) was reported to participate lncRNAs-mediated function. Herein, we propose investigate role lncRNA AC105942.1 hnRNPA2/B1 pathological possible mechanisms vitro. We have...
Atherosclerosis is an immune inflammatory disease and a major cause of mortality morbidity worldwide. It generally considered that number potent proinflammatory cytokines have great influence on its pathogenesis, including IL-1β, IL-6, TNF-α, NF-κB. A growing amount empirical evidence indicates the mechanism cardiac dysfunction caused by lipopolysaccharide (LPS) activation inflammation, but exact in atherosclerosis still unclear. Previous studies shown interferon-induced protein with...
Acute graft versus host disease (aGVHD) remains a leading cause of transplant-related mortality following allogeneic haematopoietic cell transplantation (allo-HCT). Human amniotic mesenchymal stem cells (hAMSCs) are novel (MSCs), which have stronger proliferation and immunomodulatory ability compared with bone marrow (BM-MSCs). Besides, as the membrane is often treated medical waste after delivery, hAMSCs can be obtained conveniently noninvasively. The aim this study was to explore...
To compare the biological characteristics and immunosuppressive activity between human amniotic mesenchymal stem cells (hAMSC) bone marrow (hBMMSC).MSC from amnion were isolated using enzymatic digestion Ficoll-Hypaque density gradients, respectively. Their compared by morphology, cell growth curves, cycle profile analysis, immunophenotype immunofluorescence assay. activities studied on total activated T-cells with phytohemagglutinin (PHA-PBMSC). An in vitro co-culture was performed to...
This study investigates rheological effects of blood on steady flows in a nonplanar distal end-to-side anastomosis. The shear-thinning behavior is depicted by Carreau–Yasuda model and modified power-law model. To explore nonplanarity vessel geometry, curved bypass graft considered that connects to the host artery with 90deg out-of-plane curvature. Navier–Stokes equations are solved using finite volume method. Velocity wall shear stress (WSS) compared between Newtonian non-Newtonian fluids at...
Acute myeloid leukemia (AML) is a highly heterogeneous hematologic neoplasm with poor survival outcomes. However, the routine clinical features are not sufficient to accurately predict prognosis of AML. The expression hypoxia-related genes was associated outcomes variety and lymphoid neoplasms. We established an 18-gene signature-based model (HPM) complex that consisted HPM risk factors using machine learning methods. Both two models were able effectively AML patients, which might contribute...
Acute graft-versus-host disease (aGVHD) initiated by intestinal barrier dysfunction and gut microbiota dysbiosis, remains one of the main obstacles for patients undergoing allogenic hematopoietic stem cell transplantation (allo-HSCT) to achieve good prognosis. Studies have suggested that mesenchymal cells (MSCs) can suppress immune responses reduce inflammation, human leukocyte antigen-G5 (HLA-G5) plays an important role in immunomodulatory effects MSCs, but very little is known about...