A5100352453- Immune Response and Inflammation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cytokine Signaling Pathways and Interactions
- Antimicrobial Peptides and Activities
- Immune cells in cancer
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- NF-κB Signaling Pathways
- Nanoparticle-Based Drug Delivery
- Psoriasis: Treatment and Pathogenesis
- T-cell and B-cell Immunology
- Reproductive System and Pregnancy
- Atmospheric chemistry and aerosols
- Neuroinflammation and Neurodegeneration Mechanisms
- Nanoplatforms for cancer theranostics
- Macrophage Migration Inhibitory Factor
- Pediatric health and respiratory diseases
- interferon and immune responses
- Air Quality and Health Impacts
- Monoclonal and Polyclonal Antibodies Research
- Plant responses to elevated CO2
- Ziziphus Jujuba Studies and Applications
- IL-33, ST2, and ILC Pathways
- Genetic and Kidney Cyst Diseases
- Polydiacetylene-based materials and applications
Chengdu Technological University
2024
Sichuan Agricultural University
2022-2024
Zunyi Medical University
2019-2024
Yibin University
2024
The University of Queensland
2019-2023
Southern Medical University
2023
Nanfang Hospital
2023
Poultry Research Institute
2023
Gansu Agricultural University
2023
Sichuan University
2017-2022
The MICs of cationic, hydrophobic peptides the prototypic sequence KKAAAXAAAAAXAAWAAXAAAKKKK-amide (where X is one 20 commonly occurring amino acids) are in a low micromolar range for panel gram-negative and gram-positive bacteria, with no or hemolytic activity against human rabbit erythrocytes. active only when average segmental hydrophobicity 19-residue core above an experimentally determined threshold value Phe, Trp, Leu, Ile, Met, Val, Cys, Ala). Antimicrobial could be increased by using...
NF-kappaB is critical in innate immune defense responses against invading microbial pathogens. Legionella pneumophila infection of lung macrophages causes Legionnaire's disease with pneumonia symptoms. A set NF-kappaB-controlled genes involved inflammation and anti-apoptosis are up-regulated upon L. a Dot/Icm type IV secretion system-dependent manner. Among approximately 100 substrates screened, we identified LegK1 as the sole protein that harbors highly potent NF-kappaB-stimulating...
Macrophages regulate innate immunity to maintain intestinal homeostasis and play pathological roles in inflammation. Activation of the epidermal growth factor receptor (EGFR) promotes cellular proliferation, differentiation, survival, wound closure several cell types. However, impact EGFR macrophages remains unclear. This study was investigate whether activation regulates cytokine production We found that activated colonic mice with dextran sulfate sodium (DSS)-induced colitis patients...
Codelivery of combinational antigenic peptides and adjuvant to antigen presenting cells is expected amplify tumor specific T lymphocytes immune responses while minimizing the possibility escaping reducing tolerance single peptide. However, varied hydrophobicities these multivariant derived short limit their codelivery efficiency in conventional delivery systems. Here, a facile yet effective route presented generate monodisperse stable hollow mesoporous silica nanoparticles (HMSNs) for...
Abstract Antimicrobial peptides (AMPs) are an important part of the human innate immune system for protection against bacterial infections, however AMPs display varying degrees activity Staphylococcus aureus . Previously, we showed that inactivation ATP synthase sensitizes S. towards AMP antibiotic class polymyxins. Here wondered if similarly is needed tolerance various AMPs, including β-defensins (hBD1-4), LL-37 and histatin 5. Importantly, find mutant ( atpA ) more susceptible to killing...
Dacarbazine (DTIC) is one of the most important chemotherapeutic agents for treatment melanoma; however, its poor solubility, photosensitivity, instability, and serious toxicity to normal cells limit clinical applications. In this article, we present a rationally designed nanocarrier based on hollow mesoporous silica nanoparticles (HMSNs) encapsulation targeted release DTIC eradicating melanoma. The (DTIC@HMLBFs) prepared by modifying HMSNs with carboxyl groups enhance loading DTIC, followed...
Due to the serious impact of hydrogen sulfide (H 2 S) on environment and human health, a series sensors have been increasingly used in industrial production daily life. In this work, we introduce novel, best our knowledge, detection method for trace H S liquid gaseous phases based dual-quenching mechanism (DQE) silver ion-doped nitrogen-sulfur co-doped carbon dots (N, S-CDs@Ag + ). Ag could significantly enhance fluorescence intensity sensitivity. linear range 10–120 nM solution, N, sensor...
EGF receptor (EGFR) in tumor cells serves as a promoter. However, information about EGFR activation macrophages regulating M2 polarization and development is limited. This study aimed to investigate the effects of on gastrointestinal tumors. IL-4, cytokine elicit polarization, stimulated release an ligand, HB-EGF, transactivation down-regulation Raw 264.7 peritoneal from WT mice. Knockdown HB-EGF inhibited by IL-4. IL-4-stimulated STAT6 activation, Arg1 YM1 gene expression, production were...
The IL-17-producing CD4+ T cell and γδT cells play critical roles in the pathogenesis of psoriasis (PS). PSORI-CM02 is a representative herbal formula for treatment PS South China. It was confirmed to improve without obvious side effects clinic. Here we sought clarify whether how regulates differentiation functions IMQ-induced psoriasis-like BALB/c mouse model. Mice pre-treated 3 days with significantly alleviated skin inflammation, as reduced PASI score classic psoriatic characteristics...
Abstract Mycobacterium tuberculosis , the pathogen of (TB), can survive in host macrophages and induce to M2 phenotype might result latent MTB infection. During phase, expression heat-shock protein 16.3 (Hsp16.3) is markedly increased among most bacterial proteins, but role Hsp16.3 macrophage polarization not clear. In this work, we found that incubated with 100 ng/ml production Arg-1, IL-10, TGF-beta, CD206. These results showed may phenotype. And interaction was depend on chemokine...
Highlights•Immune-specific TLR adaptor SCIMP is a scaffold for MAPK Erk1/2 in macrophages•SCIMP recruits Erk2 to cell surface ruffles and macropinosomes signaling•SCIMP-scaffolded activates c-Fos drive pro-inflammatory cytokine productionSummaryImmune cells are armed with Toll-like receptors (TLRs) sensing responding pathogens other danger cues. The role of extracellular-signal-regulated kinases 1/2 (Erk1/2) signaling remains enigmatic, both pro- anti-inflammatory functions described. We...
TLRs engage numerous adaptor proteins and signaling molecules, enabling a complex series of post-translational modifications (PTMs) to mount inflammatory responses. themselves are post-translationally modified following ligand-induced activation, with this being required relay the full spectrum proinflammatory Here, we reveal indispensable roles for TLR4 Y672 Y749 phosphorylation in mounting optimal LPS-inducible responses primary mouse macrophages. LPS promotes at both tyrosine residues,...
Innate immune signaling by Toll-like receptors (TLRs) involves receptor phosphorylation, which helps to shape and drive key inflammatory outputs, yet our understanding of the kinases mechanisms that mediate TLR phosphorylation is incomplete. Spleen tyrosine kinase (Syk) a nonreceptor protein kinase, known relay adaptive innate signaling, including from TLRs. However, TLRs do not contain conserved dual immunoreceptor tyrosine-based activation motifs typically recruit Syk many other receptors....
Marfan syndrome (MFS) is an inherited and systemic disorder. It has been reported that mutations in the fibrillin‑1 gene (FBN1) account for ~90% of autosomal dominant cases MFS. This study was conducted to screen FBN1 a Chinese family with MFS; four individuals including two patients MFS were recruited. The members underwent complete physical, cardiovascular ophthalmologic examinations. Genomic DNA samples collected from along 383 unrelated healthy subjects. coding regions amplified by...
CXCR2 is a chemokine receptor expressed on oligodendroglia that has been implicated in the pathogenesis of neuroinflammatory demyelinating diseases as well enhancement migration, proliferation, and myelin production by oligodendroglia. Using an inducible proteolipid protein (
Abstract In innate immune cells, pathogens and danger signals activate TLRs, unleashing potent tailored inflammatory responses. Previously, we reported that an immune-specific transmembrane adaptor, SLP adaptor CSK interacting membrane protein (SCIMP), interacts with TLR4 via direct binding to its cytoplasmic TIR domain. SCIMP scaffolds a Src family kinase, Lyn, for phosphorylation activation. Consequently, is able selective production of the proinflammatory cytokines IL-6 IL-12p40...