A5100425429- Liver Disease Diagnosis and Treatment
- Traditional Chinese Medicine Analysis
- Liver physiology and pathology
- Liver Disease and Transplantation
- Biochemical Acid Research Studies
- Advanced Glycation End Products research
- Lipid metabolism and disorders
- Diet, Metabolism, and Disease
- Metabolism, Diabetes, and Cancer
- Eicosanoids and Hypertension Pharmacology
- Genomics, phytochemicals, and oxidative stress
- Lipid metabolism and biosynthesis
- Endoplasmic Reticulum Stress and Disease
- Diet and metabolism studies
- Chronic Kidney Disease and Diabetes
- Adipose Tissue and Metabolism
- Pharmacological Effects of Natural Compounds
- Blood disorders and treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Inflammatory mediators and NSAID effects
- Amino Acid Enzymes and Metabolism
- Drug-Induced Hepatotoxicity and Protection
- Metabolism and Genetic Disorders
- Drug Transport and Resistance Mechanisms
- Hepatitis B Virus Studies
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2025
Institute of Hematology & Blood Diseases Hospital
2023-2025
Peking Union Medical College Hospital
2024-2025
Shanghai Medical College of Fudan University
2024
Inner Mongolia Medical University
2023
Guangxi Institute of Botany
2023
Chinese Academy of Sciences
2023
Chongqing Medical University
2022
Hebei General Hospital
2022
Nanjing University
2020
Allergic conjunctivitis (AC) has been reported to induce the instability of tear film. The protein and lipid layer play important roles in maintaining aim this study was quantify alteration major components a related secretory type IIa phospholipase A2 (sPLA2-IIa) tears seasonal allergic (SAC) perennial (PAC) patients.Twenty-one SAC PAC patients thirteen normal controls completed symptom questionnaire underwent regular ocular examination. were diagnosed based on clinical presentation...
Glomerular endothelium dysfunction leads to the progression of renal architectonic and functional abnormalities in early-stage diabetic nephropathy (DN). Advanced glycation end products (AGEs) receptor for AGEs (RAGE) are proved play important roles nephropathy. This study investigated role Salvianolic acid A (SalA) on DN its possible underlying mechanism.In vitro formation breaking rate were measured illustrate effect SalA AGEs. Type 2 rats induced by high-fat diet low-dose streptozocin...
Background/Aims: Diabetes mellitus (DM) characterized by hyperglycemia contributes to macrovascular and microvascular complications. Salvianolic acid A (SalA) is a polyphenolic compound isolated from the root of Salvia miltiorrhiza Bunge, which traditional Chinese medicine widely used treat cardiovascular diseases. However, little known about its antidiabetic effect. Our study aimed investigate in vivo vitro effect SalA underlying mechanisms. Methods: Alloxan-induced type 1 diabetic mice...
Lipid metabolism disorder and inflammation are essential promoters in pathogenesis of liver injury type 2 diabetes. Puerarin (PUR) has been reported to exert beneficial effects on many diabetic cardiovascular diseases chemical‐induced injuries, but its mechanism still unclear. The current study was designed explore the therapeutic effect PUR a rat model induced by high‐fat diet combined with low‐dose streptozotocin. rats were treated or without (100 mg/kg/day) gavaging for 8 weeks,...
Oxidative stress has been recognized as the contributor to diabetic peripheral neuropathy (DPN). Antioxidant strategies have most widely explored; nevertheless, whether antioxidants alone prevent DPN still remains inconclusive. In present study, we established an in vitro cell model for drug screening using Schwann RSC96 cells under high glucose (HG) stimulation, and found that salvianolic acid A (SalA) mitigated HG-induced injury evidenced by viability myelination. Mechanistically, SalA...
Background/Aims: Cholestatic liver diseases including primary biliary cholangitis (PBC) are associated with active hepatic fibrogenesis, which ultimately progresses to cirrhosis. Activated stellate cells (HSCs) the main fibrogenic effectors in response cholangiocyte damage. JCAD regulates cell proliferation and malignant transformation nonalcoholic steatoheaptitis-associated hepatocellular carcinoma (NASH-HCC). However, its participation cholestatic fibrosis has not been explored...
Endoplasmic reticulum (ER) stress is known to impair the function of visceral adipose tissue (VAT) and subcutaneous (SAT), disrupting lipid metabolism. Despite crucial role plays in regulating function, specific lipidomic alterations VAT SAT under ER remain unclear. In this study, was induced SAT, targeted transcriptomic approaches were used analyze metabolism gene expression profiles. The results revealed that exhibited a stronger response, characterized by significant increase binding...
ABSTRACT The addition of thrombopoietin receptor agonists (TPO‐RAs) to immunosuppressive therapy (IST) improves the hematologic response rate and quality in patients with severe aplastic anemia (SAA). However, no studies have yet reported on whether there are differences efficacy TPO‐RAs. Here, we retrospectively analyzed clinical data SAA who received hetrombopag (HPAG) or eltrombopag (EPAG) as part first‐line standard IST compare efficacy. Sixty‐seven were enrolled HPAG group 42 EPAG...
Old individuals are at a high risk of developing aplastic anemia, and immunosuppressive therapy (IST) based on anti-human T-lymphocyte immunoglobulin (ATG) cyclosporine (CsA) is recommended for treating severe anemia (SAA). Adding the thrombopoietin receptor agonist (TPO-RA) to IST could improve hematologic responses in patients with SAA; however, limited data exist elder patients. Here, we report efficacy prognostic factors associated porcine ATG CsA or without TPO-RA as first-line elderly...
Salvianolic acid A (SalA) is one of the main efficacious, water-soluble constituents Salvia miltiorrhiza Bunge. This study investigated protective effects SalA on peripheral nerve in diabetic rats. Administration (0.3, 1 and 3 mg/kg, ig) was started from 5th week after strepotozotocin (STZ60 mg/kg) intraperitoneal injection continued for 8 weeks. Paw withdrawal mechanical threshold (PWMT) motor conduction velocity (MNCV) were used to assess function. The western blot methods employed test...
Type 2 diabetes patients have an increased risk of developing hepatic fibrosis. Salvianolic acid A (SalA) has been reported to be a strong polyphenolic anti-oxidant and free radical scavenger. The aim the present study was evaluate effect SalA on pathological progression fibrosis in high-fat diet (HFD)-fed streptozotocin (STZ)-induced diabetic rats clarify underlying mechanisms. animal model with developed by high-sucrose, HFD low-dose STZ injection (i.p.). Diabetic were randomly divided...
Metabolic changes associated with diabetes are reported to lead the onset of early-stage diabetic nephropathy (DN). Furthermore, lipotoxicity is implicated in renal dysfunction. Most studies DN have focused on a single or limited number lipids, and lipidome kidney during remains be elucidated. In present study, we aimed comprehensively identify lipid abnormalities DN; this end, established an rat model by feeding high-sucrose high-fat-diet combined administration low-dose streptozotocin....
Lingguizhugan decoction, a classic traditional Chinese medicine formula, has been used to treat non-alcoholic fatty liver disease (NAFLD), however, the underlying mechanisms remains unclear. In present study, we compared phenotype of normal rats (fed with chow diet), high-fat-diet (HFD) induced NAFLD and decoction (LGZG, comprises four herbs: Poria, Ramulus Cinnamomi, Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae.) intervened rats, detected whole genome gene expression by RNA-Seq....