A5068332055- Hematopoietic Stem Cell Transplantation
- Platelet Disorders and Treatments
- Neonatal Respiratory Health Research
- Lymphoma Diagnosis and Treatment
- Iron Metabolism and Disorders
- Acute Myeloid Leukemia Research
- Hematological disorders and diagnostics
- Multiple Myeloma Research and Treatments
- Erythropoietin and Anemia Treatment
- Prenatal Screening and Diagnostics
- Respiratory Support and Mechanisms
- Hemoglobinopathies and Related Disorders
- Congenital Diaphragmatic Hernia Studies
- Mesenchymal stem cell research
Institute of Hematology & Blood Diseases Hospital
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Putian University
2023
ABSTRACT The addition of thrombopoietin receptor agonists (TPO‐RAs) to immunosuppressive therapy (IST) improves the hematologic response rate and quality in patients with severe aplastic anemia (SAA). However, no studies have yet reported on whether there are differences efficacy TPO‐RAs. Here, we retrospectively analyzed clinical data SAA who received hetrombopag (HPAG) or eltrombopag (EPAG) as part first‐line standard IST compare efficacy. Sixty‐seven were enrolled HPAG group 42 EPAG...
Background Eltrombopag (EPAG), an oral thrombopoietin receptor agonist (TPO-RA), has been proven to improve the hematologic response without increasing toxic effects as a first-line therapy combined with standard immunosuppressive treatment (IST) in adults severe aplastic anemia (SAA). Nevertheless, clinical evidence on efficacy of EPAG children acquired is limited and controversial. Methods We performed single-center, retrospective study analyze outcomes fifteen patients aged ≤18 years...
To elucidate the clinical characteristics of AA patients with cytogenetic abnormalities.We retrospectively screened 30 (30/1206, 2.5%) abnormalities from 1206 severe and very who received immunosuppressive therapy (IST) during years 2012-2019.The most common were trisomy 8 (+8, 10/30, 33.3%) loss Y (-Y, 8/30, 26.7%). The abnormal clones disappeared 6 months after IST in 14 sustained 12 patients. Patients had a lower hematologic response at than (33.3% vs. 64.3%, p = .116). IST, 5-year...
Objective: To evaluate the efficacy and safety of intravenous iron supplementation in patients with recurrent deficiency anemia (IDA) . Methods: This retrospective analysis 90 IDA from May 2012 to December 2021 was conducted, comparing therapy group oral group. Results: Among IDA, 20 were males 70 females, a median age 40 (range: 14-85) years. A total 60 received 30 supplementation. The hematologic response rates significantly higher than those at 4 8 weeks after treatment [80.0% (48/60) vs...
Incomplete pulmonary function and insufficient production of surfactant in premature infants may affect alveolar relaxation, inducing neonatal respiratory distress syndrome (NRDS). The present study was a retrospective comparison lipid metabolism indexes clinic information between NRDS non‑NRDS infants. Data on general information, pregnancy, clinical symptoms, family history as well plasma biochemical metabolic were retrospectively collected statistically analyzed from 79 patients with 44...
Objective: To reassess the predictors for response at 6 months in patients with severe or very aplastic anemia (SAA/VSAA) who failed to respond immunosuppressive therapy (IST) 3 months. Methods: We retrospectively analyzed clinical data of 173 SAA/VSAA from 2017 2018 received IST and were classified as nonresponders Univariate multivariate logistic regression analysis used evaluate factors that could predict Results: showed 3-month hemoglobin (HGB) level (P=0.017) , platelet (PLT) (P=0.005)...