A5100668358- Neuroinflammation and Neurodegeneration Mechanisms
- Gastric Cancer Management and Outcomes
- Alzheimer's disease research and treatments
- Lung Cancer Treatments and Mutations
- Colorectal Cancer Treatments and Studies
- Genetic Mapping and Diversity in Plants and Animals
- Lung Cancer Research Studies
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Cancer-related molecular mechanisms research
- Leaf Properties and Growth Measurement
- Stress Responses and Cortisol
- Lung Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Tryptophan and brain disorders
- Acute Ischemic Stroke Management
- Genetics and Plant Breeding
- Antiplatelet Therapy and Cardiovascular Diseases
- Neurological Disease Mechanisms and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Immunotherapy and Biomarkers
- Genetic and phenotypic traits in livestock
- PARP inhibition in cancer therapy
- Viral gastroenteritis research and epidemiology
- Neonatal Respiratory Health Research
Air Force Medical University
2022-2025
Lunenfeld-Tanenbaum Research Institute
2020-2025
Mount Sinai Hospital
2020-2025
Southern Medical University
2023-2025
Nanfang Hospital
2023-2025
Zhejiang Provincial People's Hospital
2025
Quzhou City People's Hospital
2016-2024
Wenzhou Medical University
2022-2024
Ministry of Agriculture and Rural Affairs
2024
Dalian Ocean University
2024
Objective To analyze the clinical application and limiting factors of Hall technique (HT) preformed metal crowns in caries primary molars to provide reference for its based on a questionnaire survey. Materials methods From June December 2022, was distributed pediatric dentists through WeChat platform using “Questionnaire Star” influencing HT molars. Results A total 700 survey questionnaires were distributed, 650 valid recovered, with effectiveness rate 92.86%. In terms awareness level HT,...
Summary Aims Both amyloid deposition and neuroinflammation appear in the early course of Alzheimer's disease ( AD ). However, progression its relationship with behavioral changes have not been fully elucidated. A better understanding role might extend our current knowledge to therapeutic intervention possibilities. Methods This study systematically characterized abnormalities APP / PS 1 transgenic mice. Brain pathology measures were performed post‐mortem brain tissues mice from 2 22 months....
Neurons suffer detrimental effects from β-amyloid toxicity in Alzheimer's disease. The exercise hormone, irisin, is found to induce a neuroprotective gene program and facilitates the beneficial on cognitive function. But no effort made test its direct protective neurons against Aβ-induced cell so far. In present study, we investigated whether irisin could protect Aβ- (25-35) induced damage explored possible underlying mechanisms. Primary cultures of astrocytes were established. Conditioned...
ABSTRACT The outbreak of novel coronavirus disease 2019 (COVID-19) has become a pandemic. Drug repurposing may represent rapid way to fill the urgent need for effective treatment. We evaluated clinical utility chloroquine and hydroxychloroquine in treating COVID-19. Forty-eight patients with moderate COVID-19 were randomized oral treatment (1000 mg QD on Day 1, then 500 9 days; n=18), (200 BID 10 or control (n=12). Adverse events mild, except one case Grade 2 ALT elevation. more commonly...
Studies have implicated astrocytic dysfunction in Alzheimer's disease (AD). However, the role of astrocytes pathophysiology and treatment is poorly characterized. Here, we identified as independent key factors involved several Alzheimer‐like phenotypes an APP/PS1 mouse model, including amyloid pathology, altered neuronal synaptic properties, impaired cognition. In vitro from mice induced synaptotoxicity well reduced dendritic complexity axonal branching hippocampal neurons. These produced...
Abstract What We Already Know about This Topic Article Tells Us That Is New Background Postoperative delirium is associated with poor long-term outcomes and increased mortality. General anesthetic drugs may contribute to because they increase cell-surface expression function of α5 subunit-containing γ-aminobutyric acid type A receptors, an effect that persists long after the have been eliminated. Dexmedetomidine, α2 adrenergic receptor agonist, prevents in patients reduces cognitive deficits...
Growing evidence has implicated that myelin deficits and neuroinflammation are the coexisted pathological features contribute to mood swing cognitive decline in major depressive disorder (MDD) multiple sclerosis (MS). Therefore, attenuation of reduction demyelination became newly emerging treatment strategies for symptoms. Antidepressant venlafaxine been used depression anxiety through its neuroprotective effects. However, it is unclear whether can improve integrity alter inflammation status...
There is an unmet need for accurate, validated, noninvasive test diagnosing and monitoring bladder cancer (BC). Detection of BC-associated mutations in urinary DNA via targeted deep sequencing could meet this need. To the ability mutational analysis to noninvasively detect BC within context haematuria investigations non–muscle-invasive (NMIBC) surveillance. Capture-based ultra-deep was performed 443 somatic 23 genes 591 urine cell-pellet DNAs from clinic patients 293 NMIBC surveillance...
Background The prevalence of major depressive disorder (MDD) is higher in those with low levels educational attainment, the unemployed and social status. However extent to which these factors cause MDD unclear. Most available data comes from studies developed countries, findings may not extrapolate developing countries. Examining relationship between socio economic status China likely add debate because radical changes occurring over last 30 years. Principal We report results 3,639 Chinese...
The triglyceride-glucose (TyG) index, a simple measure of insulin resistance, is associated with intracranial atherosclerosis (ICAS) and stroke. In hypertensive populations, this association may be pronounced. aim was to investigate the relationship between TyG symptomatic (sICAS) recurrence risk in ischemic stroke patients hypertension.This prospective, multicenter cohort study included acute minor preadmission diagnosis hypertension from September 2019 November 2021 3-month follow-up....
<title>Abstract</title> There are ~100 genes or copy number variants (CNVs) used in genetic testing for Autism Spectrum Disorder (ASD, autism). These protein-coding, and the associated phenotypes often extend beyond socio-behavioral traits seen autism including cognitive/medical complexities, epilepsy, ADHD. Here, we characterize 27 males with ASD through whole genome sequencing (WGS), delineating X-chromosome microdeletions that implicate long non-coding RNA (lncRNA)...
Background The relationship between thyroid autoimmunity (TAI) and adverse pregnancy outcomes is disputable, their dose-dependent association have not been fully clarified. Objective To investigate the effect of TAI with multiple maternal fetal-neonatal complications. Methods This study a multi-center retrospective cohort based on singleton pregnancies three medical college hospitals from July 2013 to October 2021. evolution function parameters in women were described, throughout pregnancy....
Abstract This study aimed to investigate the associations between clinical characteristics and effectiveness of anti-PD-1 inhibitors in patients with EGFR-sensitive mutations, aiming identify potential subgroup who might benefit from inhibitor treatment. Patients advanced non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR)-sensitive mutations received subsequent combination chemotherapy/antiangiogenic agents or alone after progression tyrosine kinase (TKIs)...