A5101415721- Atherosclerosis and Cardiovascular Diseases
- Air Quality and Health Impacts
- Rheumatoid Arthritis Research and Therapies
- Traditional Chinese Medicine Studies
- Systemic Lupus Erythematosus Research
- Monoclonal and Polyclonal Antibodies Research
- Peroxisome Proliferator-Activated Receptors
- Retinal Diseases and Treatments
- Climate Change and Health Impacts
- Cholesterol and Lipid Metabolism
- Healthcare and Venom Research
- Smart Materials for Construction
- Glaucoma and retinal disorders
- Immune Cell Function and Interaction
- Acute Ischemic Stroke Management
- Herpesvirus Infections and Treatments
- interferon and immune responses
- Energy and Environment Impacts
- T-cell and B-cell Immunology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pharmacological Effects of Natural Compounds
- Antiplatelet Therapy and Cardiovascular Diseases
- MicroRNA in disease regulation
- Virus-based gene therapy research
- Diabetes, Cardiovascular Risks, and Lipoproteins
First Affiliated Hospital of Guangzhou University of Chinese Medicine
2010-2025
Guangdong University Of Finances and Economics
2025
Guangdong University of Education
2025
Guangzhou University of Chinese Medicine
2017-2025
Chinese University of Hong Kong
2022-2024
Shantou University
2022-2024
Hebei Medical University
2021-2024
Key Laboratory of Guangdong Province
2024
Fudan University
2011-2024
Hunan University of Traditional Chinese Medicine
2023-2024
Diabetic retinopathy (DR) is a leading cause of blindness that poses significant public health concerns worldwide. Increasing evidence suggests neuroinflammation plays key role in the early stages DR. Microglia, long-lived immune cells central nervous system, can become activated response to pathological insults and contribute retinal neuroinflammation. However, molecular mechanisms microglial activation during DR are not fully understood. In this study, we used vivo vitro assays investigate...
β2-Glycoprotein I (β2-GPI) is a major antigen for antiphospholipid antibodies (Abs) present in patients with the syndrome (APS). We previously reported that β2-GPI specifically binds to oxidized low density lipoprotein (oxLDL), but not native (LDL). In study, ligand specific β2-GPI, oxLig-1, was purified from extracted lipids of oxLDL. The structure oxLig-1 shown be identical synthesized 7-ketocholesteryl-9-carboxynonanoate by mass spectroscopy and nuclear magnetic resonance analyses. Both...
Ag recognition and Ab production in B cells are major components of the humoral immune response. In current study, we found that core fucosylation catalyzed by α1,6-fucosyltransferase (Fut8) was required for BCR subsequent signal transduction. Moreover, compared with 3-83 cells, coalescing lipid rafts Ag-BCR endocytosis were substantially reduced Fut8-knockdown (3-83-KD) p31 stimulation then completely restored reintroduction Fut8 gene to 3-83-KD cells. Indeed, Fut8-null (Fut8(-/-)) mice...
Objective. To explore the role of leonurine in regulation synovial inflammation and joint destruction inRA. Methods. Fibroblast-like synoviocytes were isolated from tissue RA patients. Pro-inflammatory cytokine MMP expression was evaluated using real-time PCR a cytometric bead array. Cell migration invasion vitro measured Boyden chamber method scratch assay, respectively. Protein by western blotting. Nuclear factor kappa B (NF-κB) nuclear translocation detected immunofluorescence. The vivo...
Plastics breaking down of larger plastics into smaller ones (microplastics and nanoplastic) as potential threats to the ecosystem. Previous studies demonstrate that central nervous system (CNS) is a vulnerable target nanoplastics. However, potentially epigenetic biomarkers nanoplastic neurotoxicity in rodent models are still unknown. The present research aimed determine role competing endogenous RNA (ceRNA) process polystyrene nanoplastics (PS NPs) exposure-induced nerve injury. study was...
To investigate the plasma lipoprotein subclasses in patients with primary open-angle glaucoma (POAG), a total of 20 Chinese POAG on intraocular pressure (IOP)-lowering treatment and age-matched control subjects were recruited. Based levels cholesterol (TC) low-density (LDL-C), study divided into elevated- normal-level subgroups. The lipoprotein, subclasses, oxidized LDL (oxLDL) quantitatively measured. discrimination potential lipoproteins was evaluated using area under receiver operating...
Apple snails (Pomacea canaliculata), one of the 100 most serious invasive species in world, have invaded mangrove wetlands due to their salinity tolerance. We firstly prepared a plant molluscicide against apple based on Aegiceras corniculatum coastal wetland. The effects four extracts from A. corniculatum, including ethanol extract (EE), petroleum ether (PEE), ethyl acetate (EAE), and n-butanol (BE), were studied for molluscicidal activity saline environment. LC50 values at 48 h EE, PEE,...
The triglyceride-glucose (TyG) index, a simple measure of insulin resistance, is associated with intracranial atherosclerosis (ICAS) and stroke. In hypertensive populations, this association may be pronounced. aim was to investigate the relationship between TyG symptomatic (sICAS) recurrence risk in ischemic stroke patients hypertension.This prospective, multicenter cohort study included acute minor preadmission diagnosis hypertension from September 2019 November 2021 3-month follow-up....
Purpose: to determine the metabolomics profiles in plasma samples of primary open-angle glaucoma (POAG) patients. Methods: The from 20 POAG patients under intraocular pressure (IOP)-lowering medication treatment and control subjects were subjected untargeted analysis, among which 10 further oxylipin-targeted analysis by liquid chromatography–mass spectrometry analysis. prediction accuracy differentially abundant metabolites was assessed receiver operating characteristic curves. Pathway...
Abstract IFN-γ primes macrophages for antimicrobial activity, increased killing of intracellular pathogens, and Ag processing presentation to lymphocytes by cooperating with a second signal (provided LPS or endogenous TNF-α) promote proinflammatory cytokine production, NO MHC class II expression. Macrophage-stimulating protein (MSP) suppresses production activated peritoneal in vitro. Furthermore, targeted deletion the receptor MSP, stem cell-derived tyrosine kinase (STK/RON), resulted both...
β2-Glycoprotein I (β2-GPI) is a major antigen for anticardiolipin antibodies (aCL, Abs) present in patients with antiphospholipid syndrome. We recently reported that β2-GPI specifically binds to oxidized LDL (oxLDL) and the β2-GPI's ligand, oxLig-1 7-ketocholesteryl-9-carboxynonanoate (Kobayashi, K., E. Matsuura, Q. P. Liu, J. Furukawa, K. Kaihara, Inagaki, T. Atsumi, N. Sakairi, Yasuda, D. R. Voelker, Koike. 2001. A specific ligand β2-glycoprotein mediates autoantibody-dependent uptake of...
Abstract Background The evolutionary interactions between retroviruses and their receptors result in adaptive selection of restriction variants that can allow natural populations to evade retrovirus infection. mouse xenotropic/polytropic (X/PMV) gammaretroviruses rely on the XPR1 cell surface receptor for entry into host cells, polymorphic this have been identified different rodent species. Results We screened a panel X/PMVs infectivity cells carrying 6 variants. included 5...