A5046932702- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Macular Surgery
- Photoreceptor and optogenetics research
- Intraocular Surgery and Lenses
- Neuroscience and Neural Engineering
- Retinal Development and Disorders
- Advanced Memory and Neural Computing
- Ocular Infections and Treatments
- Systemic Lupus Erythematosus Research
- Acute Ischemic Stroke Management
- Optical Coherence Tomography Applications
- Vascular Malformations Diagnosis and Treatment
- EEG and Brain-Computer Interfaces
- Antioxidant Activity and Oxidative Stress
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Retinoids in leukemia and cellular processes
- Neuroinflammation and Neurodegeneration Mechanisms
- Digital Holography and Microscopy
- Ocular Disorders and Treatments
- Ocular Oncology and Treatments
Chinese University of Hong Kong
2016-2025
Hong Kong Eye Hospital
2016-2025
Prince of Wales Hospital
2014-2024
Shantou University
2018-2024
UCLouvain
2004-2010
University of Cambridge
1999
Early microvascular damage in diabetes (e.g. capillary nonperfusion and ischemia) can now be assessed quantified with optical coherence tomography-angiography (OCT-A). The morphology of vascular tissue is indeed affected by different factors; however, there a paucity data examining whether OCT-A metrics are influenced ocular, systemic demographic variables subjects diabetes. We conducted an observational cross-sectional study included 434 eyes from 286 patients Foveal avascular zone (FAZ)...
Diabetic retinopathy (DR) is a leading cause of blindness that poses significant public health concerns worldwide. Increasing evidence suggests neuroinflammation plays key role in the early stages DR. Microglia, long-lived immune cells central nervous system, can become activated response to pathological insults and contribute retinal neuroinflammation. However, molecular mechanisms microglial activation during DR are not fully understood. In this study, we used vivo vitro assays investigate...
To identify the risk factors for development of diabetic retinopathy (DR), macular edema (DME), and sight threatening DR (STDR) based on a city-wide diabetes screening program. Diabetic patients were prospectively recruited between June 2016 December 2022. All underwent dilated fundus photography centered disc macula or spectral domain optical coherence tomography (SD-OCT) scan. Complete medical history was documented.Systematic examination, blood analysis, urinalysis performed. Multivariate...
A blind volunteer, suffering from retinitis pigmentosa, has been chronically implanted with an optic nerve visual prosthesis. Vision rehabilitation this volunteer concentrated on the development of a stimulation strategy according to which video camera images are converted into pulses. The aim is convey as much information possible about scene within limits device's capabilities. Pattern recognition tasks were used assess effectiveness strategy. results demonstrate how even relatively basic...
Abstract Angiopoietin 2 (ANG2) is a proangiogenic cytokine which may have an implication in neovascular age related macular degeneration (nAMD). In 24 eyes of subjects presenting with treatment naïve nAMD and 26 control patients, aqueous humor samples were collected at the time intervention (intravitreal injection anti-vascular endothelial growth factor or cataract extraction). Best corrected visual acuity (BCVA) central thickness (CMT) using optical coherence tomography (OCT) measured...
Purpose The purpose of this study was to investigate the signal changes in choriocapillaris flow deficits and choroidal thickness using swept-source optical coherence tomography angiography (OCTA) following different treatments. Design A double-blind, randomised controlled trial. Methods Patients with unilateral chronic central serous chorioretinopathy (CSC) were receive subthreshold micropulse laser therapy (MLT) or half-dose photodynamic (PDT). Choroidal deficit signals investigated....
Diabetic macular edema (DME) is the primary cause of vision loss among individuals with diabetes mellitus (DM). We developed, validated, and tested a deep learning (DL) system for classifying DME using images from three common commercially available optical coherence tomography (OCT) devices.We trained validated two versions multitask convolution neural network (CNN) to classify (center-involved [CI-DME], non-CI-DME, or absence DME) three-dimensional (3D) volume scans 2D B-scans,...
To address the problem of teaching noncore specialties, for which there is often limited time and low student engagement, a flipped classroom case learning (FCCL) module was designed implemented in compulsory 5-day ophthalmology rotation undergraduate medical students. The consisted classroom, online gamified clinical cases, case-based learning.Final-year students were randomized to FCCL or traditional lecture-based (TLB) module. outcomes subjective assessments (student-rated anonymous...
Abstract The advent of biomacromolecules antagonizing vascular endothelial growth factor (VEGF) has revolutionized the treatment neovascular age‐related macular degeneration (nAMD). However, frequent intravitreal injections these impose an enormous burden on patients and create a massive workload for healthcare providers. This causes to abandon therapy, ultimately leading progressive irreversible vision loss. In order address this unmet clinical need, noninvasive nAMD is developed. An...
Abstract A novel device consisting of amplifiers, an analogue-digital converter, offset correction units, and a microcontroller with Bluetooth wireless functionality was fabricated. Electroretinography (ERG) recordings were captured in dark-adapted light-adapted full-field flash stimulations anaesthetised animal model using the system. Recordings repeated standard ERG recording setup Espion E3 system for comparison. The electroretinogram signal a-wave b-wave amplitudes, peak times, offset,...
Abstract Age-related macular degeneration (AMD), characterized by progressive of retinal pigment epithelium (RPE), is the major cause irreversible blindness and visual impairment in elderly population. We previously established a RPE model using an acute high dose sodium iodate to induce oxidative stress. Here we report findings on prolonged treatment low doses human cells (ARPE-19). were treated continuously with (2–10 mM) for 5 days. Low (2–5 did not reduce cell viability, which...
Purpose.: To examine the visual evoked potentials (VEP) and electroretinograms (ERG) generated during electrical stimulation of human optic nerve using prosthesis. Methods.: Two volunteers blind from retinitis pigmentosa (RP) with no light perception each received a chronically implanted Cortical were recorded 16 scalp electrodes, antidromic ERGs obtained DTL electrodes while was electrically stimulated. The results compared flash eye surface in normal-sighted control subjects. Results.:...
We determine the angiopoietin 2 (ANGPT2) gene as a new susceptibility for neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV).A total of 34 haplotype-tagging single-nucleotide polymorphisms (SNPs) were first genotyped in an exploratory Hong Kong Chinese cohort. Suggestive SNPs replicated Shantou cohort Osaka Japanese cohort, with 2343 subjects. The SNP rs800292 complement factor H (CFH) was all Genetic association gene-gene interaction analyzed.In...
Resolving three-dimensional morphological features in thick specimens remains a significant challenge for label-free imaging. We report new speckle diffraction tomography (SDT) approach that can image biological with ~500 nm lateral resolution and ~1 μm axial reflection geometry. In SDT, multiple-scattering background is rejected through spatiotemporal gating provided by dynamic speckle-field interferometry, while depth-resolved refractive index maps are reconstructed developing...
Abstract Neovascular age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV) are leading causes of irreversible blindness in developed countries. In this study, we investigated the association single nucleotide polymorphisms (SNPs) serpin peptidase inhibitor, clade G, member 1 ( SERPING1 ) gene with neovascular AMD PCV. Two haplotype-tagging SNPs, rs1005510 rs11603020, were genotyped 708 unrelated Chinese individuals: 200 AMD, 233 PCV 275 controls. A meta-analysis...
Purpose: The purpose of this study was to classify exudative maculopathy by the presence pachyvessels on en face swept-source optical coherence tomography (SSOCT). Methods: Consecutive patients with signs underwent SSOCT, fluorescein and indocyanine green angiography (ICGA), ultra-widefield fundus color photography, autofluorescence examinations. Images were analyzed in a masked fashion two sets four examiners different sessions: (1) OCT (2) features conventional imaging modalities....