A5102798731- Acute Myeloid Leukemia Research
- interferon and immune responses
- Immune Response and Inflammation
- Histone Deacetylase Inhibitors Research
- Cancer, Stress, Anesthesia, and Immune Response
- Multiple Myeloma Research and Treatments
- Immune Cell Function and Interaction
- Inflammatory mediators and NSAID effects
- Mesenchymal stem cell research
- Autoimmune and Inflammatory Disorders Research
- Cell death mechanisms and regulation
- Immune cells in cancer
- Functional Brain Connectivity Studies
- ATP Synthase and ATPases Research
- Transcranial Magnetic Stimulation Studies
- Cancer Immunotherapy and Biomarkers
- Viral Infections and Vectors
- Cytokine Signaling Pathways and Interactions
- Hematological disorders and diagnostics
- Chemokine receptors and signaling
- EEG and Brain-Computer Interfaces
- Tuberculosis Research and Epidemiology
- Neonatal Respiratory Health Research
Southern Medical University
2024-2025
Nanfang Hospital
2024-2025
Zhejiang University
2025
Sir Run Run Shaw Hospital
2025
Lanzhou University
2023-2024
University of Chinese Academy of Sciences
2019
Institute of Hydrobiology, Biology Centre, Academy of Sciences of the Czech Republic
2019
Chinese Academy of Sciences
2016-2019
Ministère de l'Agriculture et de la Souveraineté alimentaire
2019
Institute of Hydrobiology
2016
T-cell exhaustion refers to a state of dysfunction commonly observed in chronic infections and cancer. Immune checkpoint molecules blockading using PD-1 TIM-3 antibodies have shown promising results reversing exhaustion, but this approach has several limitations. The treatment is still facing great challenges, making it imperative explore new therapeutic strategies. With the development nanotechnology, nanoparticles successfully been applied as drug carriers delivery systems cancer...
Background: We aim to analyze the efficacy and safety of Venetoclax (Ven) added cladribine + cytarabine granulocyte colony-stimulating factor (G-CSF) ± idarubicin or mitoxantrone (CLAG Ida/Mito) regimen as a salvage treatment relapsed/refractory acute myeloid leukemia (RR-AML). Methods: A single-center, retrospective, cohort study was performed. Patients with RR-AML, being treated CLAG Ida/Mito versus without Ven, were retrospectively studied. The endpoints this evaluate rate composite...
Abstract Purpose T(8;21)(q22;q22.1)/AML1-ETO positive acute myeloid leukemia (AE-AML) is sensitive to conventional chemotherapy with a favorable prognosis. However, recent small case reports suggest the limited effectiveness of venetoclax (VEN) and hypomethylating agents (HMA) in treating AE-AML. The aim this retrospective study was evaluate VEN plus AZA (VA) AE-AML explore whether adding homoharringtonine (HHT) VA (VAH) could improve response. Methods Patients who received HHT or regimens...
AIM: To investigate the role of mitochondrial pathway in JTE-522-induced apoptosis and to relationship between cytochrome C release, caspase activity loss membrane potential (△Ψm). METHODS: Cell culture, cell counting, ELISA assay, TUNEL, flow cymetry, Western blot fluorometric assay were employed effect JTE-522 on proliferation AGS cells related molecular mechanism. RESULTS: inhibited growth induced apoptosis. Caspases 8 9 activated during as judged by appearance cleavage products from...
Objective Toll-like receptors (TLRs) play important role in the progression and tumor immunity of some types cancer,some research have demonstrated that agonist TLR3 can trigger apoptosis cancers.This study was proposed to investigate if Poly(I:C),the specific TLR3,could impact proliferation or progressive breast cancer cells MDA-MB-231,and primary mechanism function.Methods Expression TLR1-10 mRNA detected by quantitative real-time reverse transcription-polymerase chain reaction.Cell...
Objective To observe the effect of indomethacin on migration breast cancer cell line MCF-7 in vitro and investigate mechanism involved.Methods The stimulated with or without were tested using transwell plates consisting upper lower chambers separated by Millipore polycarbonate membrance filters 8 μm pore sizes; levels chemokine receptor 4(CXCR4),cyclooxygenase(COX-2),epidermal growth factor receptor(EGFR) vascular endothelial factor(VEGF)expression detected flow cytometry,Real-time PCR...
Abstract As a crucial signaling pathway for interferon (IFN) production, the RIG-I-like receptor (RLR) axis is usually host target of viruses to enhance viral infection. To date, though immune evasion methods contrapose IFN production have been characterized series terrestrial viruses, strategies employed by fish remain unclear. Here, we report that all grass carp reovirus (GCRV) proteins encoded segments S1 S11 interact with RLR factors, specifically mitochondrial antiviral...