A5089643077- Gastric Cancer Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Hepatitis B Virus Studies
- Colorectal Cancer Treatments and Studies
- Colorectal and Anal Carcinomas
- Liver Disease and Transplantation
- Lung Cancer Treatments and Mutations
- Cancer Treatment and Pharmacology
- Colorectal Cancer Surgical Treatments
- Hepatitis C virus research
- Esophageal and GI Pathology
- RNA modifications and cancer
- Blood Coagulation and Thrombosis Mechanisms
- Cancer Genomics and Diagnostics
- MicroRNA in disease regulation
- Hepatocellular Carcinoma Treatment and Prognosis
- Pancreatic and Hepatic Oncology Research
- Advanced Breast Cancer Therapies
- Metastasis and carcinoma case studies
- Hemophilia Treatment and Research
- Drug-Induced Hepatotoxicity and Protection
- Breast Cancer Treatment Studies
- Acute Myocardial Infarction Research
- Immune Response and Inflammation
Fudan University Shanghai Cancer Center
2016-2025
Shanghai Medical College of Fudan University
2017-2025
Jining Medical University
2025
Shanghai Clinical Research Center
2025
University of South China
2025
Zhuzhou Central Hospital
2025
Wenzhou Medical University
2010-2024
First Affiliated Hospital of Wenzhou Medical University
2009-2024
North China University of Science and Technology
2014-2024
Wuhan University
2024
Doxorubicin (DOX)-mediated cardiotoxicity can exacerbate mortality in oncology patients, but related pharmacotherapeutic measures are relatively limited. Ferroptosis was recently identified as a major mechanism of DOX-induced cardiotoxicity. Idebenone, novel ferroptosis inhibitor, is well-described clinical drug widely used. However, its role and pathological still unclear. In this study, we demonstrated the effects idebenone on elucidated underlying mechanism. A single intraperitoneal...
MicroRNAs (miRNAs) have been demonstrated to critical roles in regulating cancer cell proliferation, survival and sensitivity chemotherapy. The potential application of using miRNAs predict therapeutic response treatment holds high promise, but with predictive value remain be identified underlying mechanisms not completely understood. Here, we show a strong correlation between miR-621 expression chemosensitivity paclitaxel plus carboplatin (PTX/CBP) regimen, an effective neoadjuvant...
Background The prognostic value of tumor regression grade (TRG) after neoadjuvant chemoradiotherapy for rectal cancer is inconsistent in the literature. Both TRG and post-therapy lymph node (ypN) status could reflect efficacy therapy. Here, we explored whether combined with ypN be a factor MRI-based node-positive (cN+) following chemoradiotherapy.
Summary Long‐term prognosis varies widely among patients with hepatitis B virus ( HBV )‐related liver cirrhosis. Our study aimed to investigate the applicability of albumin‐bilirubin ALBI ), Child‐Pugh and model for end‐stage disease MELD ) scores long‐term prediction ‐related Patients diagnosed ‐associated cirrhosis from First Affiliated Hospital Wenzhou Medical University between January 2010 December 2015 were enrolled in this study. The followed up every 3 months. prognostic performance...
Summary Background Inflammation plays a vital role in liver cirrhosis progression and prognosis. Aim To investigate the prognostic significance of inflammatory response markers decompensated cirrhotic patients without acute‐on‐chronic failure ( ACLF ). Methods Independent predictors were identified using multivariate Cox model then assembled into nomogram to predict survival. Concordance index (C‐index) time‐dependent receiver operating characteristics (td‐ ROC ) analysis adopted evaluate...
Summary. The objective of this study was to determine the predictive value model for end‐stage liver disease (MELD) scoring system in patients with acute‐on‐chronic hepatitis B failure (ACLF‐HBV), and establish a new predicting prognosis ACLF‐HBV. A total 204 adult ACLF‐HBV were retrospectively recruited between July 1, 2002 December 31, 2004. MELD scores calculated according widely accepted formula. 3‐month mortality calculated. validity determined by means concordance ( c ) statistic....
Model for end-stage liver disease (MELD) scoring was initiated using traditional statistical technique by assuming a linear relationship between clinical features, but most phenomena in situation are not linearly related. The aim of this study to predict 3-month mortality risk acute-on-chronic hepatitis B failure (ACHBLF) on an individual patient level artificial neural network (ANN) system. ANN model built data from 402 consecutive patients with ACHBLF. It trained the 280 and validated...
Background: Management of patients with non-obstructive coronary artery disease (CAD) identified by CT angiography (CCTA) remains challenging due to the lacks clear guidelines. Traditional anatomical evaluation techniques might not reliably pinpoint those at an increased risk for cardiovascular events, creating a critical gap in patient care. Although derived fractional flow reserve (CT-FFR) provides non-invasive functional assessment and is increasingly recognized as crucial tool deciding...
Abstract Background Radiotherapy (RT) is an essential treatment for colorectal cancer (CRC), yet the factors influencing radiosensitivity remain unclear. In quest to enhance therapeutic efficacy in CRC, interplay between genetic mutations and RT sensitivity has emerged as a pivotal enigmatic area. Methods We harness fidelity of patient-derived organoids (PDOs) dissect molecular landscape radiosensitivity, with particular emphasis on BRAF V600E mutations. To further investigate, cohort 9...
Summary Steatosis could affect liver stiffness measurement in patients with nonalcoholic fatty disease and chronic hepatitis C. In this study, we aimed to investigate the impact of steatosis on B virus (HBV)‐infected develop a diagnostic algorithm for prediction fibrosis by based controlled attenuation parameter. A total 488 HBV ‐infected who underwent clinical examination, Fibroscan biopsy were prospectively enrolled. The best ( kP a) cut‐offs significant (S≥3) advanced (S≥4) 8.1 10.9,...
The preliminary result of the TORCH trial has shown a promising complete response (CR) for managing locally advanced rectal cancer with neoadjuvant short-course radiotherapy (SCRT) combined chemotherapy and PD-1 inhibitor. For colon (LACC) bulky nodal disease and/or clinically T4, followed by colectomy en bloc removal regional lymph nodes is suggested treatment. However, CR rate less than 5%. TORCH-C will aim to investigate SCRT inhibitor in LACC. randomised, prospective, multicentre,...
Background and purpose Recently, the rs1572931 single‐nucleotide polymorphism ( SNP ) of putative promoter member RAS oncogene family‐like 1 RAB 7L1 gene was reported to be associated with reduced risk for Parkinson's disease PD in Ashkenazi Jewish population. Ethnic‐specific effects are an important consideration genome‐wide association studies. Considering that clinical manifestations pathological characteristics overlap between , amyotrophic lateral sclerosis ALS multiple system atrophy...
We examined the relationships between N-transacetylase 2 (NAT2), cytochrome P450 (CYP) 2E1 enzyme, glutathione S-transferase M1, T1 (GSTM1/GSTT1) gene polymorphisms, and anti-tuberculosis drug-induced hepatic injury (ADIH).A one-to-one matched case-control study was carried out using clinical data.NAT2, CYP2E1, GSTM1, GSTT1 polymorphisms were identified in 173 pairs of research subjects.Statistical analysis performed to determine risk factors ADIH.The results showed that low body mass index...
Background and purpose This study aimed to evaluate the relationship between serum complement anti‐ N ‐methyl‐ d ‐aspartate receptor ( NMDAR ) encephalitis. Methods Serum (C3, C4 CH 50), immunoglobulins (IgG, IgM IgA) C‐reactive protein CRP were evaluated in 40 patients with encephalitis controls. Follow‐up evaluations of 11 conducted 6 months after admission. Modified Rankin Scale mRS scores clinical cerebrospinal fluid parameters Results levels significantly higher than controls P =...
This retrospective study was designed to evaluate the safety and efficacy of endoscopic submucosal dissection (ESD) for resection gastric tumors (SMTs) originating from muscularis propria (MP) layer at our institution.From January 2010 2014, a total 49 patients underwent ESD MP-originating SMTs. The characteristics 49patients, clinical efficacy, ESD, post-ESD pathological diagnoses were evaluated retrospectively.ESD successfully performed in 48 cases, one case converted surgery. Pathological...
DNA repair systems enable our cells to respond carcinogens and mutagens. The ERCC2 gene encodes a protein that has multiple regulatory cellular functions including nucleotide excision repair, basal transcription, cell cycle control, apoptosis. polymorphism Lys751Gln may alter the capacity for which could affect risk of certain cancers. We examined whether was associated with breast cancer in Chinese women by analysing genotype frequencies 486 patients 479 cancer-free control subjects. At...
Abstract Background Currently, the prognosis for metastatic colorectal cancer (mCRC) still remains poor. The management of mCRC has become manifold because varied advances in systemic and topical treatment approaches. For patients with limited number metastases, radical local therapy plus can be a good choice to achieve long-term tumor control. In this study, we aimed explore efficacy safety combination fruquintinib, tislelizumab, stereotactic ablative radiotherapy (SABR) (RIFLE study)....