A5045469081- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Systemic Lupus Erythematosus Research
- Extracellular vesicles in disease
- Inflammatory Bowel Disease
- Diet, Metabolism, and Disease
- Circular RNAs in diseases
- Immune Response and Inflammation
- Natural product bioactivities and synthesis
- Genomics, phytochemicals, and oxidative stress
- MicroRNA in disease regulation
- Coffee research and impacts
- Peroxisome Proliferator-Activated Receptors
- Caveolin-1 and cellular processes
- Cancer, Lipids, and Metabolism
- Lipoproteins and Cardiovascular Health
- Drug Transport and Resistance Mechanisms
- Alcohol Consumption and Health Effects
- NF-κB Signaling Pathways
- Sperm and Testicular Function
- Hepatitis B Virus Studies
Wenzhou Medical University
2017-2024
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2018-2024
First Affiliated Hospital of Wenzhou Medical University
2017-2019
MicroRNA-223-3p (miR-223-3p) is one of the potential microRNAs that have been shown to alleviate inflammatory responses in pre-clinical investigations and highly encased exosomes derived from bone mesenchymal stem cells (MSC-exosomes). MSC-exosomes are able function as carriers deliver into cells. Autoimmune hepatitis challenging liver diseases with no effective treatment other than steroid hormones. Here, we examined whether can transfer miR-223-3p treat autoimmune an experimental model. We...
In this study, we have explored the role of KATNB1 gene, a microtubule-severing protein, in seminiferous epithelium rat testis. Our data shown that expressed brain, testes, and Sertoli cells. was found to co-localize with α-tubulin showing unique stage-specific distribution across epithelium. Knockdown by RNAi led significant disruption tight junction (TJ) permeability barrier function primary cells cultured vitro an established functional TJ-barrier, as well perturbations microtubule actin...
Objective To investigate the effect of trichostatin A (TSA), a histone deacetylase inhibitor, on s-100-induced autoimmune hepatitis in mice. Methods A total 26 six-week-old male C57BL/6 mice were randomly divided into control group, model group and TSA (six each group), rest 8 used to extract s-100 protein from liver tissue. Mice injected intraperitoneally with complete Freund's adjuvant induce model. At day 21, 2 mg/(kg·d) for 7 days, 0.9% sodium chloride solution containing 1%...
Objective To study the immunoregulatory effect of sodium butyrate (NaB) on T helper cell 17(Th17) and toll-like receptor 4(TLR4) signal pathway in autoimmune hepatitis (AIH). Methods Fifty male C57BL/6 mice (6 weeks age) according to random number table method divided into control group (n=10), AIH NaB (n=10) high roughage diet (HRD) other ten were used extract hepatic sytosolic S-100. After establishment model, given 500 mg/(kg·d) by gavage those HRD fed with high-fiber stuff. 3...
Objective To investigate the effect of high-fat diet (HFD) on liver damage caused by autoimmune hepatitis (AIH) in mice. Methods Fifty C57BL/6 male mice were divided randomly into four groups: standard chow (SC) group, HFD AIH + SC group and AIH+ group. model was built after feeding for one week all sacrificed weeks. Liver spleen tissues serum collected. histopathology detected HE staining. Serum alanine aminotransperase (ALT) aspartate aminotransferase (AST) levels measured. Western...