A5024090220- Effects and risks of endocrine disrupting chemicals
- Hormonal Regulation and Hypertension
- Estrogen and related hormone effects
- Sperm and Testicular Function
- Birth, Development, and Health
- Per- and polyfluoroalkyl substances research
- Aquaculture Nutrition and Growth
- Hormonal and reproductive studies
- Reproductive Biology and Fertility
- Aquaculture disease management and microbiota
- Neonatal Respiratory Health Research
- Reproductive biology and impacts on aquatic species
- Aldose Reductase and Taurine
- Epigenetics and DNA Methylation
- Pharmacogenetics and Drug Metabolism
- Testicular diseases and treatments
- Toxic Organic Pollutants Impact
- Marine Bivalve and Aquaculture Studies
- Reproductive System and Pregnancy
- Curcumin's Biomedical Applications
- Retinoids in leukemia and cellular processes
- Adipose Tissue and Metabolism
- Congenital Diaphragmatic Hernia Studies
- Environmental Toxicology and Ecotoxicology
- Sexual Differentiation and Disorders
Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2016-2025
Wenzhou Medical University
2016-2025
Ministry of Education of the People's Republic of China
2023-2024
Shenzhen Maternity and Child Healthcare Hospital
2019-2023
Xuzhou Medical College
2023
Southern Medical University
2019-2023
Changchun University of Chinese Medicine
2022-2023
Zhejiang Institute of Communications
2022-2023
Xuzhou Central Hospital
2023
Guangdong Academy of Medical Sciences
2023
Perfluorodecanoic acid (PFDA), a C10 fluorine-containing compound, is used widely and found to be present anywhere. However, whether it has reproductive toxicity for fetal Leydig cells the underlying mechanisms remain unknown. PFDA was investigated its effects on (FLCs) following exposure 0, 1, 2.5, 5 mg/kg/days (gavage dams) from day 14 21 during gestation. The study showed that in utero medium-dose (1, 2.5 mg/kg/days) increased body weight. markedly reduced serum testosterone levels,...
Introduction: Resveratrol and its analogs have potential therapeutic usage. is metabolized to various metabolites by gut microbiota, including dihydroresveratrol, lunularin, pinostilbene, oxyresveratrol. However, they might side effects inhibiting human gonadal 3β‐hydroxysteroid dehydrogenase 2 (h3β‐HSD2) rat homolog r3β‐HSD1, thereby interfering with steroid biosynthesis. Methods: Herein, we analyzed the inhibitory strength via in vitro assay, mode of action, structure–activity...
Studies have shown that the mTORC1/rpS6 signaling cascade regulates Sertoli cell blood-testis barrier (BTB) dynamics. For instance, specific inhibition of mTORC1 by treating cells with rapamycin promotes barrier, making it "tighter." However, activation overexpressing a full-length rpS6 cDNA clone (i.e., rpS6-WT, wild type) in BTB remodeling, "leaky." Also, there is an increase and p-rpS6 (phosphorylated activated rpS6) expression at testes stages VIII-IX epithelial cycle, coincides...
Bisphenols (BPs) as endocrine-disrupting compounds have drawn attention to their health hazards. Whether a BP interferes with glucocorticoid metabolism remains unclear. 11β-Hydroxysteroid dehydrogenase 2 (11β-HSD2) is key glucocorticoid-metabolizing enzyme that controls fetal levels across the placental barrier and mineralocorticoid receptor specificity in kidney. In this study, 11 BPs were tested inhibit human rat renal 11β-HSD2 analyzed for inhibitory potency, mode action, docking...
Cadmium (Cd) is a toxic environmental pollutant with long biological half-life and can produce both hepatic renal injuries in mammals fish. Squid viscera meal (SVM), an effective attractant for aquatic animals, widely used as ingredient aquafeeds. However, SVM rich Cd its complexes. A study was conducted to evaluate the effects of dietary on growth deposition tissues Japanese seabass, Lateolabrax japonicus. Three practical diets were formulated contain 0, 50 100 g kg−1 diet, respectively,...
Human aromatase (CYP19A1) is an important enzyme, which produces estrogen from androgen for maintaining the female reproductive function and pregnancy. Triclocarban triclosan are antimicrobial chemicals added to personal care, household, industrial products. They could be endocrine disruptors may disrupt human CYP19A1 activity. In present study, we investigated effects of triclocarban on estradiol production activity in JEG-3 cells. reduced inhibited with IC