A5056735031- Neuroinflammation and Neurodegeneration Mechanisms
- Wound Healing and Treatments
- Traditional Chinese Medicine Analysis
- Pressure Ulcer Prevention and Management
- Neurological Disease Mechanisms and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Pharmacological Effects of Natural Compounds
- Biological Stains and Phytochemicals
- Immune Response and Inflammation
- Natural Compounds in Disease Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Sirtuins and Resveratrol in Medicine
- Single-cell and spatial transcriptomics
- Traditional Chinese Medicine Studies
- Tea Polyphenols and Effects
- Gut microbiota and health
- Bioactive natural compounds
- Nuclear Receptors and Signaling
- Circular RNAs in diseases
- Extracellular vesicles in disease
- Metabolomics and Mass Spectrometry Studies
- Barrier Structure and Function Studies
- Healthcare and Venom Research
- Berberine and alkaloids research
- Telomeres, Telomerase, and Senescence
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2024
China Academy of Chinese Medical Sciences
2023-2024
The high disability, mortality and morbidity of diabetic ulcers make it urgent to explore effective strategies for wound repair. TrxR1 plays a vital role in regulating redox homeostasis various pathologies. In the present study, effect berberine (BBR) on wounds was investigated streptozotocin (STZ)-induced rats glucose (HG)-induced cell model, mechanism BBR elucidated. treatment remarkably accelerated healing enhanced extracellular matrix (ECM) synthesis significantly inhibited HG-induced...
Diabetic ulcer is a challenging complication of diabetes mellitus but current treatments cannot achieve satisfactory results. In this study, the effect Huangbai liniment (HB) and berberine on wound healing in high fat diet/streptozotocin injection induced diabetic rats was investigated by RNA-seq technology. HB topical treatment promoted patients rats, it affected multiple processes, which IL-17 signalling pathway importance. Inhibiting IL-17a its inhibitor or antibody remarkably facilitated...
C5ar1 (CD88) has been identified as an important potential therapeutic target for regulating inflammation in ischemic stroke. In this study, the neuroprotective effect of Guhong injection (GHI) on middle cerebral artery occlusion (MCAO)-induced reperfusion injury was assessed and mechanism explored by RNA-seq technology. GHI administered 6 consecutive days significantly decreased body weight loss, infarction rate, neurological deficient scores, neuron loss but improved rat survival...
Diabetic ulcers bring about high morbidity and mortality in patients cause a great economic burden to society as whole. Since existing treatments cannot fulfil patient requirements, it is urgent find effective therapies. In this study, the wound healing effect of topical notoginsenoside R1 (NR1) treatment on diabetic full-thickness wounds type II diabetes mellitus (T2DM) was induced by combination high-fat diet streptozotocin (STZ) injection. NR1 significantly increased closure rate,...
Duzhi Wan (DZW) has been extensively used in the prevention and treatment of ischemic stroke, but mechanisms underlying its effects remain unclear. In this study, a combination transcriptomics, metabolomics network analysis was applied to identify preventive mechanism DZW middle cerebral artery occlusion (MCAO)-induced ischemia/reperfusion (I/R) injury.The mice were divided into five groups: sham group, I/R + Ginaton I/R+DZW-L I/R+DZW-H group. Neurological deficit scores regional blood flow...
Dengzhan Shengmai (DZSM), a traditional Chinese medicine formulation, has been administered extensively to elderly individuals with cognitive impairment (CI). However, the underlying mechanisms by which improves remains unknown. This study aimed elucidate mechanism of effect on aging-associated via comprehensive combination transcriptomics and microbiota assessment. was orally D-galactose-induced aging mouse model, evaluation an open field task (OFT), Morris water maze (MWM),...
This study investigated the anti-aging mechanism of Xiyangshen Sanqi Danshen Granules based on metabonomics, network pharmacology, and molecular docking. The aging mice model was induced by intraperitoneal injection D-galactose(D-gal). Mice were randomly divided into a control group, melatonin group(MT group), low, medium, high dose groups Granules(XSD-L, XSD-M, XSD-H). An open-field experiment conducted, expression cell cycle arrest proteins(p16) phosphorylated histone family 2A...
Introduction: Diabetic ulcers have become one of the major complications diabetes mellitus (DM) and are a leading cause death disabling disease. However, current therapies not effective enough to meet clinical needs. A traditional Chinese medicine (TCM) formula, Pien Tze Huang (PZH), is known as that used treat diabetic ulcers. Methods: In this study, PZH (0.05 g/cm 2 0.15 ) positive drug-rhEGF were topically administered in high-fat diet (HFD) streptozotocin (STZ)-induced full-thickness...
Thrombolysis causes irreversible injury and is often more severe than occlusion itself in ischemic stroke. This study was to investigate the effect mechanism of a novel prescription CAP with 5:5:1 ratio Coptidis rhizoma alkaloids (CRA), Astragalus membranaceus astragalosides (AS), Panax notoginseng saponins (PNS) on reperfusion (I/R) brain neuroprotective by inhibiting activation C3 as core complement system. An optimal CRA, AS, PNS identified H2O2-induced PC12 cell damage model detecting...
Thrombolysis causes irreversible injury and is often more severe than occlusion itself in ischemic stroke. This study was to investigate the effect mechanism of a novel prescription CAP with 5:5:1 ratio Coptidis rhizoma alkaloids (CRA), Astragalus membranaceus astragalosides (AS), Panax notoginseng saponins (PNS) on stroke reperfusion injury. Network pharmacological analysis showed that combination rhizoma, membranaceus, affected 15 biological processes or pathways closely related cerebral...