A5062151438- Gut microbiota and health
- Probiotics and Fermented Foods
- Metabolomics and Mass Spectrometry Studies
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Alcohol Consumption and Health Effects
- Forest, Soil, and Plant Ecology in China
- Lipid metabolism and biosynthesis
- Infant Nutrition and Health
- Ginseng Biological Effects and Applications
- Dengue and Mosquito Control Research
- Peroxisome Proliferator-Activated Receptors
- Pediatric health and respiratory diseases
- Biochemical Analysis and Sensing Techniques
- Cancer Research and Treatments
- Clostridium difficile and Clostridium perfringens research
- Phytochemistry and biological activity of medicinal plants
- Advanced Nanomaterials in Catalysis
- Food composition and properties
- Microbial Metabolism and Applications
Institute of Microbiology
2023-2024
Chinese Academy of Sciences
2023-2024
University of Chinese Academy of Sciences
2023-2024
Shanxi University
2021-2023
The potentially beneficial effects of probiotics in the treatment obesity have been generally demonstrated. In present study, a new strain
Non-alcoholic fatty liver disease (NAFLD) is a serious health problem worldwide. Impeding acid uptake may be an attractive therapeutic strategy for NAFLD. In the current study, we found that millet bran protein hydrolysate (MBPH) prepared by in vitro gastrointestinal bionic digestion exhibits potential of anti-NAFLD and vivo, characterized alleviation hepatic steatosis reduction lipid accumulation. Further, MBPH significantly decreased expression levels related genes (FABP1, FABP2, FABP4,...
Abstract Prolonged alcohol consumption disrupts the gut microbiota and immune system, contributing to pathogenesis of alcohol‐associated liver disease (ALD). Probiotic‐postbiotic intervention strategies can effectively relieve ALD by maintaining homeostasis. Herein, efficacy heat‐killed Lactobacillus johnsonii (HKLJ) in mitigating alcoholic damage is demonstrated mouse models ALD. The gut‐liver axis identified as a pivotal pathway for protective effects L. against Specifically, HKLJ found...
Foxtail millet proteins and their hydrolysates have the potential to prevent atherosclerosis (AS). In our present study, a novel Bowman-Birk type major trypsin inhibitor from foxtail bran (FMB-BBTI) with an anti-AS effect was obtained by in vitro gastrointestinal bionic digestion. Further, activity of FMB-BBTI verified classic apoE-/- mice model, characterized decreases inflammatory cytokines (TNF-α IL-1β) atherosclerotic plaque. Importantly, remodeled structure gut microbiota mice,...
Molecular targeted therapy has become an emerging promising strategy in cancer treatment, and screening the agents targeting at cell specific targets is very desirable for treatment. Our previous study firstly found that a secretory peroxidase of class III derived from foxtail millet bran (FMBP) exhibited excellent anti-colorectal (CRC) activity vivo vitro, whereas its underlying target remains unclear. The highlight present focuses on finding surface glucose-regulated protein 78 (csGRP78)...
Metabolic syndrome (MetS) is a chronic disease associated with the disturbance of gut microbiota homeostasis. Metabolites derived from microbes play essential roles in MetS prevention and therapy. Here, we focused on inhibitory effect extract millet bran protein (EMBP) high-fat diet (HFD)-induced MetS, aiming to identify their metabolites that involve anti-MetS activity EMBP. The obesity, inflammation, insulin resistance mouse models were abolished after EMBP treatment. protective mechanism...