A5022972901- Rabies epidemiology and control
- Poxvirus research and outbreaks
- Microbial infections and disease research
- Viral Infections and Vectors
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Virology and Viral Diseases
- Animal Virus Infections Studies
- Vector-Borne Animal Diseases
- Viral Infections and Outbreaks Research
- Bacillus and Francisella bacterial research
- Hepatitis Viruses Studies and Epidemiology
- Yersinia bacterium, plague, ectoparasites research
- Bacteriophages and microbial interactions
- Vector-borne infectious diseases
- Plant Virus Research Studies
- Mosquito-borne diseases and control
- Viral Infectious Diseases and Gene Expression in Insects
- Viral Infections and Immunology Research
- Streptococcal Infections and Treatments
- Liver Disease and Transplantation
- Toxin Mechanisms and Immunotoxins
- Respiratory viral infections research
- Autophagy in Disease and Therapy
- Toxoplasma gondii Research Studies
Chinese Academy of Agricultural Sciences
2022-2025
Jilin Academy of Agricultural Sciences
2023-2024
Academy of Military Medical Sciences
2016-2020
Jilin Agricultural University
2020
Jilin University
2020
Xinjiang Uygur Autonomous Region Disease Prevention and Control Center
2020
Yangzhou University
2020
Bats are associated with the circulation of most mammalian filoviruses (FiVs), pathogenic ones frequently causing deadly hemorrhagic fevers in Africa. Divergent FiVs have been uncovered Chinese bats, raising concerns about their threat to public health. Here, we describe a long-term surveillance track bat at orchards, eventually resulting identification and isolation FiV, Dehong virus (DEHV), from Rousettus leschenaultii bats. DEHV has typical filovirus-like morphology wide spectrum cell...
Rabies is a severe zoonotic disease in China, but the circulation and distribution of rabies virus (RABV) within animal reservoirs not well understood. We report results 15 years surveillance first Chinese Surveillance Plan populations, which brain tissues collected during 2004-2018 were tested for RABV phylogenetic spatial-temporal evolutionary analyses performed using obtained sequences. The have provided most comprehensive dataset to date on infected species, geographic distribution,...
Four species of porcine circoviruses (PCV1-4) have been reported to circulate in Chinese domestic pigs, while the epizootiology these viruses free-ranging wild boars China remains unknown. In this study, tissue and serum samples collected from diseased or apparently healthy between 2018 2020 19 regions were tested for prevalence PCV1-4 infections. Positive rates PCV1, PCV2, PCV3 DNA 1.6% (4/247), 58.3% (144/247), 10.9% (27/247) respectively, with none positive PCV4. Sequence analysis viral...
The compound 1,2,3,4,6-penta-O-galloyl-β-d-glucose (PGG), a gallotannin present in various plants such as Rhus chinensis Mill and Paeonia suffruticosa, has broad spectrum of antiviral effects. study investigated its potency against infection mice with rabies virus (RABV). Results demonstrated that PGG strongly inhibited titers (50-fold), viral mRNA expression (up to 90%), protein synthesis vitro. Importantly, we found not only suppressed adsorption entry, but also directly inactivated RABV...
Our previous study showed that pentagalloylglucose (PGG), a naturally occurring hydrolyzable phenolic tannin, possesses significant anti-rabies virus (RABV) activity. In BHK-21 cells, RABV induced the overactivation of signal transducer and activator transcription 3 (STAT3) by suppressing expression suppressor cytokine signaling (SOCS3). Inhibition STAT3 niclosamide, small interfering RNA, or exogenous SOCS3 all significantly suppressed replication RABV. Additionally, RABV-induced...
Rabies is a serious public health issue in China, with over 95% of human infections transmitted by dogs. As part routine surveillance carried out the Inner Mongolia Autonomous Region (IMAR) between 2019 and 2021, 80 95 suspected rabies cases domestic animals (dogs, livestock) wild carnivores (foxes, badgers, raccoon dog) were confirmed as virus (RABV) positive. Phylogenetic analysis RABVs based on complete N genes showed that 97.5% (78/80) strains belonged to Cosmopolitan (steppe-type)...
Eastern roe deer (Capreolus pygargus) is a small ruminant and widespread across China. This creature plays an important role in our ecological system. Although few studies have been conducted to investigate pathogens harbored by this species, knowledge of the virus diversity still very sparse. In study, we whole virome profiling rescue-failed deer, which revealed kobuvirus (KoV), bocaparvovirus (BoV), multiple circular single-stranded viruses. These viruses were mainly recovered from rectum,...
Abstract Background Ticks are medically important vectors capable of transmitting a variety pathogens to and between host species. Although the spectrum tick-borne RNA viruses has been frequently investigated, diversity DNA remains largely unknown. Methods A total 1571 ticks were collected from forests infested animals, they harbored was profiled using DNA-specific virome method. The viromic data phylogenetically analyzed validated by PCR assays. Results diverse abundant prokaryotic...
As a small top predator, Amur leopard cat (Prionailurus bengalensis euptilurus) is widely distributed in northeast Asia and plays an important role the control of rodent populations maintenance ecological equilibrium. However, viruses harbored by this creature have been rarely investigated. Here, we report DNA RNA eukaryotic virome profiling injured followed PCR validation, which revealed diverse anelloviruses multiple organs bocaparvovirus lymph, but no viruses. These genomic structures are...
Hepatitis E virus (HEV), the causative agent of hepatitis (HE), is classified into four major genotypes (1-4), with wild boar being main natural reservoir for 3 and 4. However, little known about prevalence HEV infection in boars China. In this study, RT-nested PCR RT-quantitative were used to detect RNA tissue samples taken from 331 free-ranging collected between 2018 2020 24 regions across China, partial ORF2 genes or complete genomes positive sequenced. Furthermore, antibodies against 216...
South-East Asia (SEA) and South (SA) are two important geographic regions with the most severe enzootic rabies in world. In these regions, phylogenetic analysis of virus (RABV) has been conducted only at a country level; results obtained from different countries scattered unequal, non-uniform system to name RABV genotypes. Therefore, it is difficult undertake origin-tracking compare inter-country evolution transmission. To avoid confusion understanding generate panoramic picture genetic...
To detect rabies virus and other member species of the genus Lyssavirus within family Rhabdoviridae, pan-lyssavirus nested reverse transcription polymerase chain reaction (nested RT-PCR) was developed to conserved region nucleoprotein (N) gene lyssaviruses. The method applies (RT) using viral RNA as template oligo (dT)15 random hexamers primers synthesize complementary DNA (cDNA). Then, cDNA is used a amplify an 845 bp N fragment in first-round PCR outer primers, followed by second-round...
To detect rabies virus and other member species of the genus Lyssavirus within family Rhabdoviridae, pan-lyssavirus nested reverse transcription polymerase chain reaction (nested RT-PCR) was developed to conserved region nucleoprotein (N) gene lyssaviruses. The method applies (RT) using viral RNA as template oligo (dT)15 random hexamers primers synthesize complementary DNA (cDNA). Then, cDNA is used a amplify an 845 bp N fragment in first-round PCR outer primers, followed by second-round...